Independent and synergistic activity of the flavonoids of Gracilaria corticata as promising antidiabetic agents
The therapeutic approaches for Type 2 Diabetes Mellitus rely most on the usage of oral hypoglycaemic drugs. These drugs have adverse side effects and hence alternative medicines are continuously explored. The present study intends to investigate the antidiabetic potential of the flavonoids present i...
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2021-04-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100618&tlng=en |
| _version_ | 1811273383421149184 |
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| author | Ragupathy Sangeetha |
| author_facet | Ragupathy Sangeetha |
| author_sort | Ragupathy Sangeetha |
| collection | DOAJ |
| description | The therapeutic approaches for Type 2 Diabetes Mellitus rely most on the usage of oral hypoglycaemic drugs. These drugs have adverse side effects and hence alternative medicines are continuously explored. The present study intends to investigate the antidiabetic potential of the flavonoids present in Gracilaria corticata. The flavonoids were isolated (FEGC) and their inhibitory activity on the carbohydrate hydrolysing enzymes such as α-amylase and α-glucosidase was analysed. The flavonoids were found to inhibit α-amylase and α-glucosidase with an IC50 value of 302 µg and 75 µg respectively. The synergistic effect of FEGC and luteolin was also investigated and the results show that both FEGC and luteolin inhibited synergistically at half their IC50 values. The observations of this study reveal that the flavonoids of G. corticata have potential antidiabetic activity and can act independently or synergistically in the management of Type 2 Diabetes Mellitus |
| first_indexed | 2024-04-12T22:58:08Z |
| format | Article |
| id | doaj.art-b4105338f5ca42529988e6ec7800a672 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-04-12T22:58:08Z |
| publishDate | 2021-04-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-b4105338f5ca42529988e6ec7800a6722022-12-22T03:13:08ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902021-04-015610.1590/s2175-97902019000418766Independent and synergistic activity of the flavonoids of Gracilaria corticata as promising antidiabetic agentsRagupathy Sangeethahttps://orcid.org/0000-0002-5299-0224The therapeutic approaches for Type 2 Diabetes Mellitus rely most on the usage of oral hypoglycaemic drugs. These drugs have adverse side effects and hence alternative medicines are continuously explored. The present study intends to investigate the antidiabetic potential of the flavonoids present in Gracilaria corticata. The flavonoids were isolated (FEGC) and their inhibitory activity on the carbohydrate hydrolysing enzymes such as α-amylase and α-glucosidase was analysed. The flavonoids were found to inhibit α-amylase and α-glucosidase with an IC50 value of 302 µg and 75 µg respectively. The synergistic effect of FEGC and luteolin was also investigated and the results show that both FEGC and luteolin inhibited synergistically at half their IC50 values. The observations of this study reveal that the flavonoids of G. corticata have potential antidiabetic activity and can act independently or synergistically in the management of Type 2 Diabetes Mellitushttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100618&tlng=enα-amylaseα-glucosidaseAntidiabeticGracilaria corticataLuteolinSynergistic |
| spellingShingle | Ragupathy Sangeetha Independent and synergistic activity of the flavonoids of Gracilaria corticata as promising antidiabetic agents Brazilian Journal of Pharmaceutical Sciences α-amylase α-glucosidase Antidiabetic Gracilaria corticata Luteolin Synergistic |
| title | Independent and synergistic activity of the flavonoids of Gracilaria corticata as promising antidiabetic agents |
| title_full | Independent and synergistic activity of the flavonoids of Gracilaria corticata as promising antidiabetic agents |
| title_fullStr | Independent and synergistic activity of the flavonoids of Gracilaria corticata as promising antidiabetic agents |
| title_full_unstemmed | Independent and synergistic activity of the flavonoids of Gracilaria corticata as promising antidiabetic agents |
| title_short | Independent and synergistic activity of the flavonoids of Gracilaria corticata as promising antidiabetic agents |
| title_sort | independent and synergistic activity of the flavonoids of gracilaria corticata as promising antidiabetic agents |
| topic | α-amylase α-glucosidase Antidiabetic Gracilaria corticata Luteolin Synergistic |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100618&tlng=en |
| work_keys_str_mv | AT ragupathysangeetha independentandsynergisticactivityoftheflavonoidsofgracilariacorticataaspromisingantidiabeticagents |