A Novel Inhibitor against the Biofilms of Non-Tuberculous Mycobacteria
Non-tuberculous Mycobacteria (NTM), previously classified as environmental microbes, have emerged as opportunistic pathogens causing pulmonary infections in immunocompromised hosts. The formation of the biofilm empowers NTM pathogens to escape from the immune response and antibiotic action, leading...
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| Format: | Article |
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MDPI AG
2023-12-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/13/1/40 |
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| author | Parvinder Kaur Ramya Vadageri Krishnamurthy Radha Krishan Shandil Rahul Mohan Shridhar Narayanan |
| author_facet | Parvinder Kaur Ramya Vadageri Krishnamurthy Radha Krishan Shandil Rahul Mohan Shridhar Narayanan |
| author_sort | Parvinder Kaur |
| collection | DOAJ |
| description | Non-tuberculous Mycobacteria (NTM), previously classified as environmental microbes, have emerged as opportunistic pathogens causing pulmonary infections in immunocompromised hosts. The formation of the biofilm empowers NTM pathogens to escape from the immune response and antibiotic action, leading to treatment failures. NF1001 is a novel thiopeptide antibiotic first-in-class compound with potent activity against planktonic/replicating and biofilm forms of various NTM species. It is potent against both drug-sensitive and -resistant NTM. It has demonstrated a concentration-dependent killing of replicating and intracellularly growing NTM, and has inhibited and reduced the viability of NTM in biofilms. Combination studies using standard-of-care (SoC) drugs for NTM exhibited synergetic/additive effects, but no antagonism against both planktonic and biofilm populations of <i>Mycobacterium abscessus</i> and <i>Mycobacterium avium</i>. In summary, the activity of NF1001 alone or in combination with SoC drugs projects NF1001 as a promising candidate for the treatment of difficult-to-treat NTM pulmonary diseases (NTM-PD) and cystic fibrosis (CF) in patients. |
| first_indexed | 2024-03-08T10:38:44Z |
| format | Article |
| id | doaj.art-b411ef4cee1b49f58c2477928534aa66 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-08T10:38:44Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-b411ef4cee1b49f58c2477928534aa662024-01-26T18:03:15ZengMDPI AGPathogens2076-08172023-12-011314010.3390/pathogens13010040A Novel Inhibitor against the Biofilms of Non-Tuberculous MycobacteriaParvinder Kaur0Ramya Vadageri Krishnamurthy1Radha Krishan Shandil2Rahul Mohan3Shridhar Narayanan4Foundation for Neglected Disease Research (FNDR), Doddaballapur, Bengaluru 561203, Karnataka, IndiaFoundation for Neglected Disease Research (FNDR), Doddaballapur, Bengaluru 561203, Karnataka, IndiaFoundation for Neglected Disease Research (FNDR), Doddaballapur, Bengaluru 561203, Karnataka, IndiaNational Center for Polar & Ocean Research (NCPOR), Headland Sada, Vasco da Gama 403802, Goa, IndiaFoundation for Neglected Disease Research (FNDR), Doddaballapur, Bengaluru 561203, Karnataka, IndiaNon-tuberculous Mycobacteria (NTM), previously classified as environmental microbes, have emerged as opportunistic pathogens causing pulmonary infections in immunocompromised hosts. The formation of the biofilm empowers NTM pathogens to escape from the immune response and antibiotic action, leading to treatment failures. NF1001 is a novel thiopeptide antibiotic first-in-class compound with potent activity against planktonic/replicating and biofilm forms of various NTM species. It is potent against both drug-sensitive and -resistant NTM. It has demonstrated a concentration-dependent killing of replicating and intracellularly growing NTM, and has inhibited and reduced the viability of NTM in biofilms. Combination studies using standard-of-care (SoC) drugs for NTM exhibited synergetic/additive effects, but no antagonism against both planktonic and biofilm populations of <i>Mycobacterium abscessus</i> and <i>Mycobacterium avium</i>. In summary, the activity of NF1001 alone or in combination with SoC drugs projects NF1001 as a promising candidate for the treatment of difficult-to-treat NTM pulmonary diseases (NTM-PD) and cystic fibrosis (CF) in patients.https://www.mdpi.com/2076-0817/13/1/40drug resistanceplanktonicbiofilmnon-tubercular mycobacteria<i>Mycobacterium abscessus</i> (Mabs)<i>Mycobacterium avium</i> (Mav) |
| spellingShingle | Parvinder Kaur Ramya Vadageri Krishnamurthy Radha Krishan Shandil Rahul Mohan Shridhar Narayanan A Novel Inhibitor against the Biofilms of Non-Tuberculous Mycobacteria Pathogens drug resistance planktonic biofilm non-tubercular mycobacteria <i>Mycobacterium abscessus</i> (Mabs) <i>Mycobacterium avium</i> (Mav) |
| title | A Novel Inhibitor against the Biofilms of Non-Tuberculous Mycobacteria |
| title_full | A Novel Inhibitor against the Biofilms of Non-Tuberculous Mycobacteria |
| title_fullStr | A Novel Inhibitor against the Biofilms of Non-Tuberculous Mycobacteria |
| title_full_unstemmed | A Novel Inhibitor against the Biofilms of Non-Tuberculous Mycobacteria |
| title_short | A Novel Inhibitor against the Biofilms of Non-Tuberculous Mycobacteria |
| title_sort | novel inhibitor against the biofilms of non tuberculous mycobacteria |
| topic | drug resistance planktonic biofilm non-tubercular mycobacteria <i>Mycobacterium abscessus</i> (Mabs) <i>Mycobacterium avium</i> (Mav) |
| url | https://www.mdpi.com/2076-0817/13/1/40 |
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