A versatile engineered extracellular vesicle platform simultaneously targeting and eliminating senescent stromal cells and tumor cells to promote tumor regression
Abstract Chemotherapy is an important therapeutic approach for malignant tumors for it triggers apoptosis of cancer cells. However, chemotherapy also induces senescence of stromal cells in the tumor microenvironment to promote tumor progression. Strategies aimed at killing tumor cells while simultan...
Main Authors: | Liangzhi Gong, Zhengsheng Chen, Kai Feng, Lei Luo, Juntao Zhang, Ji Yuan, Yajing Ren, Yang Wang, Xianyou Zheng, Qing Li |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2024-03-01
|
Series: | Journal of Nanobiotechnology |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12951-024-02361-3 |
Similar Items
-
Spheroid size influences cellular senescence and angiogenic potential of mesenchymal stromal cell-derived soluble factors and extracellular vesicles
by: Matteo Rovere, et al.
Published: (2023-12-01) -
Senescent Stromal Cells in the Tumor Microenvironment: Victims or Accomplices?
by: Minghan Ye, et al.
Published: (2023-03-01) -
Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stromal Cells as an Efficient Nanocarrier to Deliver siRNA or Drug to Pancreatic Cancer Cells
by: Florian Draguet, et al.
Published: (2023-05-01) -
Therapeutic Perspectives for Inflammation and Senescence in Osteoarthritis Using Mesenchymal Stem Cells, Mesenchymal Stem Cell-Derived Extracellular Vesicles and Senolytic Agents
by: Michael G. Rizzo, et al.
Published: (2023-05-01) -
Immunophenotype of Replicative Senescent Mesenchymal Stromal Cells
by: A. Yu. Ratushnyy
Published: (2023-12-01)