Clinical comparison of HMPV and RSV infections in hospitalised Malaysian children: A propensity score matched study
Abstract Introduction Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are significant contributors to the burden of acute respiratory infections in children, but data on hMPV from Southeast Asia are limited despite its potential for serious disease. This study aimed to compare the...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | The Clinical Respiratory Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/crj.13747 |
| _version_ | 1797244507085864960 |
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| author | David Chun‐Ern Ng Chuin‐Hen Liew Kah Kee Tan Elida Hanan binti Awang Farah Nuruliayana binti Ahmad Nazri Asuwani K. Tamil Maran Vishnu Arvindran a/l Chandra Mohan Durairaaj Ramachandran Michelle Chok Cheah Hooi Teh Airena Mohamad Nor Suhaila bt Baharuddin Erwin Jiayuan Khoo |
| author_facet | David Chun‐Ern Ng Chuin‐Hen Liew Kah Kee Tan Elida Hanan binti Awang Farah Nuruliayana binti Ahmad Nazri Asuwani K. Tamil Maran Vishnu Arvindran a/l Chandra Mohan Durairaaj Ramachandran Michelle Chok Cheah Hooi Teh Airena Mohamad Nor Suhaila bt Baharuddin Erwin Jiayuan Khoo |
| author_sort | David Chun‐Ern Ng |
| collection | DOAJ |
| description | Abstract Introduction Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are significant contributors to the burden of acute respiratory infections in children, but data on hMPV from Southeast Asia are limited despite its potential for serious disease. This study aimed to compare the clinical presentation, resource utilisation and outcomes between hMPV and RSV infections in hospitalised Malaysian children. Methods This retrospective, observational study included children aged ≤12 years old hospitalised with hMPV or RSV, confirmed via direct fluorescent antibody (DFA) methods, between 1 July to 30 October 2022 at Hospital Tuanku Ja'afar Seremban, Malaysia. Demographic, clinical presentation, resource utilisation and outcome data were analysed. Propensity score matching was used to balance cohorts based on key demographic and clinical characteristics. Results This study included 192 patients, comprising 112 with hMPV and 80 with RSV. hMPV patients were older (median age 20.5 vs. 9.4 months, p < 0.001) and had a higher incidence of comorbidities (24.1% vs. 7.5%, p = 0.003). Fever was more common in the hMPV group (97.3% vs. 73.8%, p < 0.001), but the other clinical manifestations were similar. Postmatching analysis showed higher corticosteroid use in the hMPV group (p = 0.01). No significant differences were observed in the use of other resources, PICU admissions, duration of hospitalisation or mortality rates between both groups. Conclusion hMPV and RSV infections in children share similar clinical manifestations and outcomes, with hMPV affecting older children and showing higher corticosteroid usage. These findings emphasise the need for equal clinical vigilance for both hMPV and RSV in paediatric respiratory infections. |
| first_indexed | 2024-04-24T19:12:06Z |
| format | Article |
| id | doaj.art-b4159101c375495581a80870bdabed66 |
| institution | Directory Open Access Journal |
| issn | 1752-6981 1752-699X |
| language | English |
| last_indexed | 2024-04-24T19:12:06Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Clinical Respiratory Journal |
| spelling | doaj.art-b4159101c375495581a80870bdabed662024-03-26T09:34:38ZengWileyThe Clinical Respiratory Journal1752-69811752-699X2024-03-01183n/an/a10.1111/crj.13747Clinical comparison of HMPV and RSV infections in hospitalised Malaysian children: A propensity score matched studyDavid Chun‐Ern Ng0Chuin‐Hen Liew1Kah Kee Tan2Elida Hanan binti Awang3Farah Nuruliayana binti Ahmad Nazri4Asuwani K. Tamil Maran5Vishnu Arvindran a/l Chandra Mohan6Durairaaj Ramachandran7Michelle Chok8Cheah Hooi Teh9Airena Mohamad Nor10Suhaila bt Baharuddin11Erwin Jiayuan Khoo12Hospital Tuanku Ja'afar Ministry of Health Malaysia Seremban MalaysiaHospital Tuanku Ampuan Najihah Ministry of Health Malaysia Kuala Pilah MalaysiaDepartment of Paediatrics Perdana University Seremban Clinical Academic Center Seremban MalaysiaHospital Tuanku Ja'afar Ministry of Health Malaysia Seremban MalaysiaHospital Tuanku Ja'afar Ministry of Health Malaysia Seremban MalaysiaHospital Tuanku Ja'afar Ministry of Health Malaysia Seremban MalaysiaHospital Tuanku Ja'afar Ministry of Health Malaysia Seremban MalaysiaHospital Tuanku Ampuan Najihah Ministry of Health Malaysia Kuala Pilah MalaysiaHospital Tuanku Ja'afar Ministry of Health Malaysia Seremban MalaysiaHospital Tuanku Ja'afar Ministry of Health Malaysia Seremban MalaysiaHospital Tuanku Ja'afar Ministry of Health Malaysia Seremban MalaysiaHospital Tuanku Ja'afar Ministry of Health Malaysia Seremban MalaysiaDepartment of Paediatrics International Medical University Kuala Lumpur MalaysiaAbstract Introduction Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are significant contributors to the burden of acute respiratory infections in children, but data on hMPV from Southeast Asia are limited despite its potential for serious disease. This study aimed to compare the clinical presentation, resource utilisation and outcomes between hMPV and RSV infections in hospitalised Malaysian children. Methods This retrospective, observational study included children aged ≤12 years old hospitalised with hMPV or RSV, confirmed via direct fluorescent antibody (DFA) methods, between 1 July to 30 October 2022 at Hospital Tuanku Ja'afar Seremban, Malaysia. Demographic, clinical presentation, resource utilisation and outcome data were analysed. Propensity score matching was used to balance cohorts based on key demographic and clinical characteristics. Results This study included 192 patients, comprising 112 with hMPV and 80 with RSV. hMPV patients were older (median age 20.5 vs. 9.4 months, p < 0.001) and had a higher incidence of comorbidities (24.1% vs. 7.5%, p = 0.003). Fever was more common in the hMPV group (97.3% vs. 73.8%, p < 0.001), but the other clinical manifestations were similar. Postmatching analysis showed higher corticosteroid use in the hMPV group (p = 0.01). No significant differences were observed in the use of other resources, PICU admissions, duration of hospitalisation or mortality rates between both groups. Conclusion hMPV and RSV infections in children share similar clinical manifestations and outcomes, with hMPV affecting older children and showing higher corticosteroid usage. These findings emphasise the need for equal clinical vigilance for both hMPV and RSV in paediatric respiratory infections.https://doi.org/10.1111/crj.13747hMPVpaediatricpredictorsRSVseverity |
| spellingShingle | David Chun‐Ern Ng Chuin‐Hen Liew Kah Kee Tan Elida Hanan binti Awang Farah Nuruliayana binti Ahmad Nazri Asuwani K. Tamil Maran Vishnu Arvindran a/l Chandra Mohan Durairaaj Ramachandran Michelle Chok Cheah Hooi Teh Airena Mohamad Nor Suhaila bt Baharuddin Erwin Jiayuan Khoo Clinical comparison of HMPV and RSV infections in hospitalised Malaysian children: A propensity score matched study The Clinical Respiratory Journal hMPV paediatric predictors RSV severity |
| title | Clinical comparison of HMPV and RSV infections in hospitalised Malaysian children: A propensity score matched study |
| title_full | Clinical comparison of HMPV and RSV infections in hospitalised Malaysian children: A propensity score matched study |
| title_fullStr | Clinical comparison of HMPV and RSV infections in hospitalised Malaysian children: A propensity score matched study |
| title_full_unstemmed | Clinical comparison of HMPV and RSV infections in hospitalised Malaysian children: A propensity score matched study |
| title_short | Clinical comparison of HMPV and RSV infections in hospitalised Malaysian children: A propensity score matched study |
| title_sort | clinical comparison of hmpv and rsv infections in hospitalised malaysian children a propensity score matched study |
| topic | hMPV paediatric predictors RSV severity |
| url | https://doi.org/10.1111/crj.13747 |
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