Advances in Polymeric Micelles: Responsive and Targeting Approaches for Cancer Immunotherapy in the Tumor Microenvironment
In recent years, to treat a diverse array of cancer forms, considerable advancements have been achieved in the field of cancer immunotherapies. However, these therapies encounter multiple challenges in clinical practice, such as high immune-mediated toxicity, insufficient accumulation in cancer tiss...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/11/2622 |
| _version_ | 1797458061612285952 |
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| author | Lichun Cheng Jiankun Yu Tangna Hao Wenshuo Wang Minjie Wei Guiru Li |
| author_facet | Lichun Cheng Jiankun Yu Tangna Hao Wenshuo Wang Minjie Wei Guiru Li |
| author_sort | Lichun Cheng |
| collection | DOAJ |
| description | In recent years, to treat a diverse array of cancer forms, considerable advancements have been achieved in the field of cancer immunotherapies. However, these therapies encounter multiple challenges in clinical practice, such as high immune-mediated toxicity, insufficient accumulation in cancer tissues, and undesired off-target reactions. To tackle these limitations and enhance bioavailability, polymer micelles present potential solutions by enabling precise drug delivery to the target site, thus amplifying the effectiveness of immunotherapy. This review article offers an extensive survey of recent progress in cancer immunotherapy strategies utilizing micelles. These strategies include responsive and remodeling approaches to the tumor microenvironment (TME), modulation of immunosuppressive cells within the TME, enhancement of immune checkpoint inhibitors, utilization of cancer vaccine platforms, modulation of antigen presentation, manipulation of engineered T cells, and targeting other components of the TME. Subsequently, we delve into the present state and constraints linked to the clinical utilization of polymeric micelles. Collectively, polymer micelles demonstrate excellent prospects in tumor immunotherapy by effectively addressing the challenges associated with conventional cancer immunotherapies. |
| first_indexed | 2024-03-09T16:31:42Z |
| format | Article |
| id | doaj.art-b415c5b1de6a4e90ab6c277b7214f4ea |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T16:31:42Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-b415c5b1de6a4e90ab6c277b7214f4ea2023-11-24T15:01:10ZengMDPI AGPharmaceutics1999-49232023-11-011511262210.3390/pharmaceutics15112622Advances in Polymeric Micelles: Responsive and Targeting Approaches for Cancer Immunotherapy in the Tumor MicroenvironmentLichun Cheng0Jiankun Yu1Tangna Hao2Wenshuo Wang3Minjie Wei4Guiru Li5Department of Pharmacy, The Second Hospital of Dalian Medical University, Dalian 116027, ChinaSchool of Pharmacy, China Medical University, Shenyang 110122, ChinaDepartment of Pharmacy, The Second Hospital of Dalian Medical University, Dalian 116027, ChinaDepartment of Pharmacy, The Second Hospital of Dalian Medical University, Dalian 116027, ChinaSchool of Pharmacy, China Medical University, Shenyang 110122, ChinaDepartment of Pharmacy, The Second Hospital of Dalian Medical University, Dalian 116027, ChinaIn recent years, to treat a diverse array of cancer forms, considerable advancements have been achieved in the field of cancer immunotherapies. However, these therapies encounter multiple challenges in clinical practice, such as high immune-mediated toxicity, insufficient accumulation in cancer tissues, and undesired off-target reactions. To tackle these limitations and enhance bioavailability, polymer micelles present potential solutions by enabling precise drug delivery to the target site, thus amplifying the effectiveness of immunotherapy. This review article offers an extensive survey of recent progress in cancer immunotherapy strategies utilizing micelles. These strategies include responsive and remodeling approaches to the tumor microenvironment (TME), modulation of immunosuppressive cells within the TME, enhancement of immune checkpoint inhibitors, utilization of cancer vaccine platforms, modulation of antigen presentation, manipulation of engineered T cells, and targeting other components of the TME. Subsequently, we delve into the present state and constraints linked to the clinical utilization of polymeric micelles. Collectively, polymer micelles demonstrate excellent prospects in tumor immunotherapy by effectively addressing the challenges associated with conventional cancer immunotherapies.https://www.mdpi.com/1999-4923/15/11/2622polymeric micellescancer immunotherapytumor microenvironmentresponsive delivery systemstargeted drug delivery |
| spellingShingle | Lichun Cheng Jiankun Yu Tangna Hao Wenshuo Wang Minjie Wei Guiru Li Advances in Polymeric Micelles: Responsive and Targeting Approaches for Cancer Immunotherapy in the Tumor Microenvironment Pharmaceutics polymeric micelles cancer immunotherapy tumor microenvironment responsive delivery systems targeted drug delivery |
| title | Advances in Polymeric Micelles: Responsive and Targeting Approaches for Cancer Immunotherapy in the Tumor Microenvironment |
| title_full | Advances in Polymeric Micelles: Responsive and Targeting Approaches for Cancer Immunotherapy in the Tumor Microenvironment |
| title_fullStr | Advances in Polymeric Micelles: Responsive and Targeting Approaches for Cancer Immunotherapy in the Tumor Microenvironment |
| title_full_unstemmed | Advances in Polymeric Micelles: Responsive and Targeting Approaches for Cancer Immunotherapy in the Tumor Microenvironment |
| title_short | Advances in Polymeric Micelles: Responsive and Targeting Approaches for Cancer Immunotherapy in the Tumor Microenvironment |
| title_sort | advances in polymeric micelles responsive and targeting approaches for cancer immunotherapy in the tumor microenvironment |
| topic | polymeric micelles cancer immunotherapy tumor microenvironment responsive delivery systems targeted drug delivery |
| url | https://www.mdpi.com/1999-4923/15/11/2622 |
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