Trends of Hypercholesterolemia Change in Shenzhen, China During 1997–2018
To demonstrate the trends of hypercholesterolemia change in Shenzhen, China from 1997 to 2018. Participants were residents aged 18 to 69 years in Shenzhen, China, and were recruited using multi-stage cluster sampling. All participants were surveyed about their socio-demographics, lifestyle, occupati...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.887065/full |
| _version_ | 1818139100541091840 |
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| author | Ke Peng Ke Peng Weicong Cai Weicong Cai Xiaoying Liu Yishu Liu Yu Shi Jessica Gong Lin Lei Ji Peng Yuxin Xie Yuxin Xie Honglei Zhao Lei Si Menglu Ouyang Menglu Ouyang |
| author_facet | Ke Peng Ke Peng Weicong Cai Weicong Cai Xiaoying Liu Yishu Liu Yu Shi Jessica Gong Lin Lei Ji Peng Yuxin Xie Yuxin Xie Honglei Zhao Lei Si Menglu Ouyang Menglu Ouyang |
| author_sort | Ke Peng |
| collection | DOAJ |
| description | To demonstrate the trends of hypercholesterolemia change in Shenzhen, China from 1997 to 2018. Participants were residents aged 18 to 69 years in Shenzhen, China, and were recruited using multi-stage cluster sampling. All participants were surveyed about their socio-demographics, lifestyle, occupation, mental health, and social support. Physical measurements and blood samples for subsequent measurements were collected according to a standardized protocol. A total of 26,621 individuals participated in the three surveys with 8,266 in 1997, 8,599 in 2009, and 9,756 in 2018. In both women and men, there was a significant downward linear trend in age-adjusted mean high-density lipoprotein-cholesterol (HDL-C) from 1997 to 2018 (women: 0.17 ± 0.06, p = 0.008 vs. men: 0.21 ± 0.04, p < 0.001). In contrast, the age-adjusted total triglycerides and total cholesterol in both sexes have demonstrated an increasing trend in the past two decades. However, no significant changes in age-adjusted low-density lipoprotein-cholesterol (LDL-C) in both men and women between 2009 and 2018 were found (women: 0.00 ± 0.02, p = 0.85 vs. men 0.02 ± 0.03, p = 0.34). The age-adjusted prevalence of hypercholesterolemia observed a rapid rise from 1997 to 2009 and appeared to be stabilized in 2018, which was similar to the trend of the prevalence of high total triglycerides in women. Changes in trends were varied by different types of lipids traits. Over the observed decades, there was a clear increasing trend of prevalence of low HDL-C (<1.04 mmol/L) in both sexes (women: 8.8% in 1997 and doubled to reach 17.5% in 2018 vs. men was 22.1% in 1997 and increased to 39.1% in 2018), particularly among younger age groups. Hence, a bespoke public health strategy aligned with the characteristics of lipids epidemic considered by sex and age groups needs to be developed and implemented. |
| first_indexed | 2024-12-11T10:22:43Z |
| format | Article |
| id | doaj.art-b417a0d079b94b2eb6cc17bd47449b8d |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-12-11T10:22:43Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-b417a0d079b94b2eb6cc17bd47449b8d2022-12-22T01:11:18ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-05-011010.3389/fpubh.2022.887065887065Trends of Hypercholesterolemia Change in Shenzhen, China During 1997–2018Ke Peng0Ke Peng1Weicong Cai2Weicong Cai3Xiaoying Liu4Yishu Liu5Yu Shi6Jessica Gong7Lin Lei8Ji Peng9Yuxin Xie10Yuxin Xie11Honglei Zhao12Lei Si13Menglu Ouyang14Menglu Ouyang15National Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen, ChinaShenzhen Center for Chronic Disease Control, Shenzhen, ChinaShenzhen Center for Chronic Disease Control, Shenzhen, ChinaThe George Institute for Global Health, University of New South Wales, Sydney, NSW, AustraliaSchool of Medical Science, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, AustraliaThe George Institute for Global Health, University of New South Wales, Sydney, NSW, AustraliaNational Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen, ChinaThe George Institute for Global Health, University of New South Wales, Sydney, NSW, AustraliaShenzhen Center for Chronic Disease Control, Shenzhen, ChinaShenzhen Center for Chronic Disease Control, Shenzhen, ChinaNational Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen, ChinaSchool of Public Health, Hengyang Medical School, University of South China, Shenzhen, ChinaNational Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen, ChinaThe George Institute for Global Health, University of New South Wales, Sydney, NSW, AustraliaThe George Institute for Global Health, University of New South Wales, Sydney, NSW, AustraliaThe George Institute China at Peking University Health Science Center, Beijing, ChinaTo demonstrate the trends of hypercholesterolemia change in Shenzhen, China from 1997 to 2018. Participants were residents aged 18 to 69 years in Shenzhen, China, and were recruited using multi-stage cluster sampling. All participants were surveyed about their socio-demographics, lifestyle, occupation, mental health, and social support. Physical measurements and blood samples for subsequent measurements were collected according to a standardized protocol. A total of 26,621 individuals participated in the three surveys with 8,266 in 1997, 8,599 in 2009, and 9,756 in 2018. In both women and men, there was a significant downward linear trend in age-adjusted mean high-density lipoprotein-cholesterol (HDL-C) from 1997 to 2018 (women: 0.17 ± 0.06, p = 0.008 vs. men: 0.21 ± 0.04, p < 0.001). In contrast, the age-adjusted total triglycerides and total cholesterol in both sexes have demonstrated an increasing trend in the past two decades. However, no significant changes in age-adjusted low-density lipoprotein-cholesterol (LDL-C) in both men and women between 2009 and 2018 were found (women: 0.00 ± 0.02, p = 0.85 vs. men 0.02 ± 0.03, p = 0.34). The age-adjusted prevalence of hypercholesterolemia observed a rapid rise from 1997 to 2009 and appeared to be stabilized in 2018, which was similar to the trend of the prevalence of high total triglycerides in women. Changes in trends were varied by different types of lipids traits. Over the observed decades, there was a clear increasing trend of prevalence of low HDL-C (<1.04 mmol/L) in both sexes (women: 8.8% in 1997 and doubled to reach 17.5% in 2018 vs. men was 22.1% in 1997 and increased to 39.1% in 2018), particularly among younger age groups. Hence, a bespoke public health strategy aligned with the characteristics of lipids epidemic considered by sex and age groups needs to be developed and implemented.https://www.frontiersin.org/articles/10.3389/fpubh.2022.887065/fulllipids managementhypercholesterolemiaChinacholesterolepidemiology |
| spellingShingle | Ke Peng Ke Peng Weicong Cai Weicong Cai Xiaoying Liu Yishu Liu Yu Shi Jessica Gong Lin Lei Ji Peng Yuxin Xie Yuxin Xie Honglei Zhao Lei Si Menglu Ouyang Menglu Ouyang Trends of Hypercholesterolemia Change in Shenzhen, China During 1997–2018 Frontiers in Public Health lipids management hypercholesterolemia China cholesterol epidemiology |
| title | Trends of Hypercholesterolemia Change in Shenzhen, China During 1997–2018 |
| title_full | Trends of Hypercholesterolemia Change in Shenzhen, China During 1997–2018 |
| title_fullStr | Trends of Hypercholesterolemia Change in Shenzhen, China During 1997–2018 |
| title_full_unstemmed | Trends of Hypercholesterolemia Change in Shenzhen, China During 1997–2018 |
| title_short | Trends of Hypercholesterolemia Change in Shenzhen, China During 1997–2018 |
| title_sort | trends of hypercholesterolemia change in shenzhen china during 1997 2018 |
| topic | lipids management hypercholesterolemia China cholesterol epidemiology |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.887065/full |
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