Osteopontin as a marker in thyroid disease: Relation to body mass index
ABSTRACT: Background: Thyroid diseases are considered of the most common and important endocrinological disorders that are associated with multiple deleterious effects. Osteopontin (OPN), a molecule first identified in osteoblasts, is a multifunctional protein involved in inflammation, cell adhesio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-07-01
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| Series: | Endocrine and Metabolic Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666396120300030 |
| _version_ | 1831583459028500480 |
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| author | Hanaa Tarek El-Zawawy Aliaa Ali El-Aghoury Eman Zaki Azzam Akram Abdel Moneim Deghady Marzouk Arafa Abdellatif |
| author_facet | Hanaa Tarek El-Zawawy Aliaa Ali El-Aghoury Eman Zaki Azzam Akram Abdel Moneim Deghady Marzouk Arafa Abdellatif |
| author_sort | Hanaa Tarek El-Zawawy |
| collection | DOAJ |
| description | ABSTRACT: Background: Thyroid diseases are considered of the most common and important endocrinological disorders that are associated with multiple deleterious effects. Osteopontin (OPN), a molecule first identified in osteoblasts, is a multifunctional protein involved in inflammation, cell adhesion & remodeling. It has been suggested that OPN plays a role in many diseases. Aim of the work: To assess the alteration of serum OPN in patients with several forms of thyroid dysfunction and the relation of OPN to body mass index (BMI) in those patients. Patients and methods: Study subjects were recruited from the endocrine outpatient clinic in Alexandria Main University Hospital. They were divided into; Group I: 25 hyperthyroid patients, Group II: 25 hypothyroid patients, and Group III: 25 healthy euthyroid subjects as a control group. Results: OPN was significantly higher in hyperthyroid group than in control group (mean 11.07 ± 2.87 µg/l Vs mean 6.50 ± 1.71 µg/l, p<0.001) while, it was significantly lower in hypothyroid group than in control group (mean 4.07 ± 1.30 µg/l Vs mean 6.50 ± 1.71 µg/l, p<0.001). OPN showed a significant positive correlation with TRAbs and a significant negative correlation with BMI. Conclusion: Direct relationship existed between OPN and thyroid hormones. OPN was significantly negatively correlated with BMI in patients with hyperthyroidism; hence OPN can be suggested to act as a mediator of BMI change in hyperthyroid patients. |
| first_indexed | 2024-12-17T20:42:33Z |
| format | Article |
| id | doaj.art-b418d7889d6845d9a3cb2656eecb0336 |
| institution | Directory Open Access Journal |
| issn | 2666-3961 |
| language | English |
| last_indexed | 2024-12-17T20:42:33Z |
| publishDate | 2020-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Endocrine and Metabolic Science |
| spelling | doaj.art-b418d7889d6845d9a3cb2656eecb03362022-12-21T21:33:15ZengElsevierEndocrine and Metabolic Science2666-39612020-07-0111100049Osteopontin as a marker in thyroid disease: Relation to body mass indexHanaa Tarek El-Zawawy0Aliaa Ali El-Aghoury1Eman Zaki Azzam2Akram Abdel Moneim Deghady3Marzouk Arafa Abdellatif4Internal Medicine department, Endocrinology unit, Faculty of Medicine, Alexandria University, Egypt; Correspondig author:Internal Medicine department, Endocrinology unit, Faculty of Medicine, Alexandria University, EgyptInternal Medicine department, Endocrinology unit, Faculty of Medicine, Alexandria University, EgyptClinical pathology department, Faculty of Medicine, Alexandria University, EgyptInternal Medicine department, Endocrinology unit, Faculty of Medicine, Alexandria University, EgyptABSTRACT: Background: Thyroid diseases are considered of the most common and important endocrinological disorders that are associated with multiple deleterious effects. Osteopontin (OPN), a molecule first identified in osteoblasts, is a multifunctional protein involved in inflammation, cell adhesion & remodeling. It has been suggested that OPN plays a role in many diseases. Aim of the work: To assess the alteration of serum OPN in patients with several forms of thyroid dysfunction and the relation of OPN to body mass index (BMI) in those patients. Patients and methods: Study subjects were recruited from the endocrine outpatient clinic in Alexandria Main University Hospital. They were divided into; Group I: 25 hyperthyroid patients, Group II: 25 hypothyroid patients, and Group III: 25 healthy euthyroid subjects as a control group. Results: OPN was significantly higher in hyperthyroid group than in control group (mean 11.07 ± 2.87 µg/l Vs mean 6.50 ± 1.71 µg/l, p<0.001) while, it was significantly lower in hypothyroid group than in control group (mean 4.07 ± 1.30 µg/l Vs mean 6.50 ± 1.71 µg/l, p<0.001). OPN showed a significant positive correlation with TRAbs and a significant negative correlation with BMI. Conclusion: Direct relationship existed between OPN and thyroid hormones. OPN was significantly negatively correlated with BMI in patients with hyperthyroidism; hence OPN can be suggested to act as a mediator of BMI change in hyperthyroid patients.http://www.sciencedirect.com/science/article/pii/S2666396120300030OsteopontinThyroidBMI |
| spellingShingle | Hanaa Tarek El-Zawawy Aliaa Ali El-Aghoury Eman Zaki Azzam Akram Abdel Moneim Deghady Marzouk Arafa Abdellatif Osteopontin as a marker in thyroid disease: Relation to body mass index Endocrine and Metabolic Science Osteopontin Thyroid BMI |
| title | Osteopontin as a marker in thyroid disease: Relation to body mass index |
| title_full | Osteopontin as a marker in thyroid disease: Relation to body mass index |
| title_fullStr | Osteopontin as a marker in thyroid disease: Relation to body mass index |
| title_full_unstemmed | Osteopontin as a marker in thyroid disease: Relation to body mass index |
| title_short | Osteopontin as a marker in thyroid disease: Relation to body mass index |
| title_sort | osteopontin as a marker in thyroid disease relation to body mass index |
| topic | Osteopontin Thyroid BMI |
| url | http://www.sciencedirect.com/science/article/pii/S2666396120300030 |
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