Demethylating Agents in the Treatment of Cancer

Demethylating Agents in the Treatment of Cancer

Gene silencing resulting from aberrant DNA methylation can lead to tumorigenesis. Therefore, drugs that inhibit or interfere with DNA methylation have been used to reactivate and induce silenced gene re-expression in malignancies. Two demethylating agents, azacitidine and decitabine, are approved fo...

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Bibliographic Details
Main Authors: Paul M. Howell, Jr., Zixing Liu, Hung T. Khong
Format: Article
Language:English
Published: MDPI AG 2010-07-01
Series:Pharmaceuticals
Subjects:
azacitidine
cancer
decitabine
epigenetics
methylation
Online Access:http://www.mdpi.com/1424-8247/3/7/2022/

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