Clinical and pathophysiological aspects of non-motor manifestations of Parkinson's disease
Non-motor symptoms are an essential manifestation of the clinical picture of Parkinson's disease (PD). This literature review is devoted to the study of recent advances in the field of clinical and pathophysiological aspects of the non-motor manifestations of Parkinson's disease.Aim. The a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2020-01-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/2574 |
| _version_ | 1797872846597259264 |
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| author | M. A. Nikitina N. G. Zhukova E. Yu. Bragina V. M. Alifirova I. A. Zhukova D. E. Gomboeva E. S. Kolupaeva I. Zh. Zhalsanova |
| author_facet | M. A. Nikitina N. G. Zhukova E. Yu. Bragina V. M. Alifirova I. A. Zhukova D. E. Gomboeva E. S. Kolupaeva I. Zh. Zhalsanova |
| author_sort | M. A. Nikitina |
| collection | DOAJ |
| description | Non-motor symptoms are an essential manifestation of the clinical picture of Parkinson's disease (PD). This literature review is devoted to the study of recent advances in the field of clinical and pathophysiological aspects of the non-motor manifestations of Parkinson's disease.Aim. The aim was to study and generalize the wide range of non-motor manifestations of PD and their features in this pathology, and to reveal the pathophysiological link between motor and non-motor manifestations of the disease and the role of the neurodegenerative process in the clinical picture of PD.Materials and methods. Keywords (Parkinson's disease, non-motor symptoms, apathy, anxiety, depression, sleep disorder, pain) search in the Web of Science, Core Collection, Scopus, Pubmed databases.Results. Knowledge about the presence of PD non-motor symptoms, characteristics of their manifestations improve their diagnosis and help to choose the correct treatment strategy. This survey comprises nonmotor manifestations of PD, such as: mood disorders (apathy, anxiety, depression), impulse control disorders (dopamine disregulation syndrome), sleep disorders (insomnia, excessive daytime sleepiness, bouts of sleepiness, conduct disorder in REM phase of sleep), autonomic disorders (constipation, enuresis, thermoregulatory dysfunction, cardiovascular disorders, orthostatic hypotension), and cognitive impairment. |
| first_indexed | 2024-04-10T01:06:43Z |
| format | Article |
| id | doaj.art-b41b3e3af76847718b819f38c3ff78c3 |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:06:43Z |
| publishDate | 2020-01-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-b41b3e3af76847718b819f38c3ff78c32023-03-13T09:58:25ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842020-01-0118422223210.20538/1682-0363-2019-4-222-2321582Clinical and pathophysiological aspects of non-motor manifestations of Parkinson's diseaseM. A. Nikitina0N. G. Zhukova1E. Yu. Bragina2V. M. Alifirova3I. A. Zhukova4D. E. Gomboeva5E. S. Kolupaeva6I. Zh. Zhalsanova7Сибирский государственный медицинский университет (СибГМУ)Сибирский государственный медицинский университет (СибГМУ)Научно-исследовательский институт (НИИ) медицинской генетики, Томский национальный исследовательский медицинский центр (НИМЦ) Российской академии наукСибирский государственный медицинский университет (СибГМУ)Сибирский государственный медицинский университет (СибГМУ)Научно-исследовательский институт (НИИ) медицинской генетики, Томский национальный исследовательский медицинский центр (НИМЦ) Российской академии наукСибирский государственный медицинский университет (СибГМУ)Научно-исследовательский институт (НИИ) медицинской генетики, Томский национальный исследовательский медицинский центр (НИМЦ) Российской академии наукNon-motor symptoms are an essential manifestation of the clinical picture of Parkinson's disease (PD). This literature review is devoted to the study of recent advances in the field of clinical and pathophysiological aspects of the non-motor manifestations of Parkinson's disease.Aim. The aim was to study and generalize the wide range of non-motor manifestations of PD and their features in this pathology, and to reveal the pathophysiological link between motor and non-motor manifestations of the disease and the role of the neurodegenerative process in the clinical picture of PD.Materials and methods. Keywords (Parkinson's disease, non-motor symptoms, apathy, anxiety, depression, sleep disorder, pain) search in the Web of Science, Core Collection, Scopus, Pubmed databases.Results. Knowledge about the presence of PD non-motor symptoms, characteristics of their manifestations improve their diagnosis and help to choose the correct treatment strategy. This survey comprises nonmotor manifestations of PD, such as: mood disorders (apathy, anxiety, depression), impulse control disorders (dopamine disregulation syndrome), sleep disorders (insomnia, excessive daytime sleepiness, bouts of sleepiness, conduct disorder in REM phase of sleep), autonomic disorders (constipation, enuresis, thermoregulatory dysfunction, cardiovascular disorders, orthostatic hypotension), and cognitive impairment.https://bulletin.ssmu.ru/jour/article/view/2574болезнь паркинсонанемоторные проявленияапатиятревогадепрессиясонливостьболь |
| spellingShingle | M. A. Nikitina N. G. Zhukova E. Yu. Bragina V. M. Alifirova I. A. Zhukova D. E. Gomboeva E. S. Kolupaeva I. Zh. Zhalsanova Clinical and pathophysiological aspects of non-motor manifestations of Parkinson's disease Бюллетень сибирской медицины болезнь паркинсона немоторные проявления апатия тревога депрессия сонливость боль |
| title | Clinical and pathophysiological aspects of non-motor manifestations of Parkinson's disease |
| title_full | Clinical and pathophysiological aspects of non-motor manifestations of Parkinson's disease |
| title_fullStr | Clinical and pathophysiological aspects of non-motor manifestations of Parkinson's disease |
| title_full_unstemmed | Clinical and pathophysiological aspects of non-motor manifestations of Parkinson's disease |
| title_short | Clinical and pathophysiological aspects of non-motor manifestations of Parkinson's disease |
| title_sort | clinical and pathophysiological aspects of non motor manifestations of parkinson s disease |
| topic | болезнь паркинсона немоторные проявления апатия тревога депрессия сонливость боль |
| url | https://bulletin.ssmu.ru/jour/article/view/2574 |
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