Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons

Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons

<p>Abstract</p> <p>There are three peroxisome proliferator-activated receptors (PPARs) subtypes which are commonly designated PPAR alpha, PPAR gamma and PPAR beta/delta. PPAR alpha activation increases high density lipoprotein (HDL) cholesterol synthesis, stimulates "reverse&q...

Full description

Bibliographic Details
Main Authors:	Tenenbaum Alexander, Motro Michael, Fisman Enrique Z
Format:	Article
Language:	English
Published:	BMC 2005-09-01
Series:	Cardiovascular Diabetology
Online Access:	http://www.cardiab.com/content/4/1/14

Similar Items

Metabolic syndrome and type 2 diabetes mellitus: focus on peroxisome proliferator activated receptors (PPAR)
by: Fisman Enrique Z, et al.
Published: (2003-03-01)

Balanced pan-PPAR activator bezafibrate in combination with statin: comprehensive lipids control and diabetes prevention?
by: Tenenbaum Alexander, et al.
Published: (2012-11-01)

Does the lipid-lowering peroxisome proliferator-activated receptors ligand bezafibrate prevent colon cancer in patients with coronary artery disease?
by: Shemesh Joseph, et al.
Published: (2008-06-01)

Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) γ activators and pan-PPAR partial agonists.
by: Marcelo Vizoná Liberato, et al.
Published: (2012-01-01)

Oxaliplatin neurotoxicity involves peroxisome alterations. PPARγ agonism as preventive pharmacological approach.
by: Matteo Zanardelli, et al.
Published: (2014-01-01)

Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Trophoblast Functions
by: Lin Peng, et al.
Published: (2021-01-01)

The Effect of Peroxisome Proliferator-Activated Receptors (PPARs) in Male Fertility
by: Motahareh Sadat Mousavi, et al.
Published: (2020-09-01)

Downregulation of peroxisome proliferator-activated receptors (PPARs) in nasal polyposis
by: Adner Mikael, et al.
Published: (2005-11-01)

Oleamide activates peroxisome proliferator-activated receptor gamma (PPARγ) <it>in vitro</it>
by: Dionisi Mauro, et al.
Published: (2012-05-01)

Myelin Disruption, Neuroinflammation, and Oxidative Stress Induced by Sulfite in the Striatum of Rats Are Mitigated by the pan-PPAR agonist Bezafibrate
by: Nícolas Manzke Glänzel, et al.
Published: (2023-06-01)

Peroxisome Proliferator-Activated Receptors (PPARs) and Oxidative Stress in Physiological Conditions and in Cancer
by: Giuliana Muzio, et al.
Published: (2021-10-01)

Effect of Pesticides on Peroxisome Proliferator-Activated Receptors (PPARs) and Their Association with Obesity and Diabetes
by: J. Hernández-Valdez, et al.
Published: (2023-01-01)

Functions of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Gynecologic Disorders
by: Ping Ren, et al.
Published: (2015-04-01)

Functions of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Gynecologic Disorders
by: Ping Ren, et al.
Published: (2015-01-01)

Sinapic acid attenuates cisplatin-induced nephrotoxicity through peroxisome proliferator-activated receptor gamma agonism in rats
by: Hardevinder Pal Singh, et al.
Published: (2020-01-01)

The expression of peroxisome proliferator-activated receptor (ppar1 and ppar2) in naive and memory cd4+ t lymphocytes
by: Mohamed, Rafeezul
Published: (2006)

Losartan and diabetic nephropathy: commentaries on the RENAAL study
by: Tenenbaum Alexander, et al.
Published: (2002-04-01)

Marine Natural and Nature-Inspired Compounds Targeting Peroxisome Proliferator Activated Receptors (PPARs)
by: Enrico D’Aniello, et al.
Published: (2023-01-01)

Multifaceted roles of peroxisome proliferator-activated receptors (PPARs) at the cellular and whole organism levels
by: A Yessoufou, et al.
Published: (2010-09-01)

Astaxanthin as a Peroxisome Proliferator-Activated Receptor (PPAR) Modulator: Its Therapeutic Implications
by: Chang-Ik Choi
Published: (2019-04-01)

Peroxisome Proliferator-Activated Receptors (PPARs): from metabolic control to epidermal wound healing
by: Swiss Medical Weekly
Published: (2002-02-01)

Different skeletal effects of the peroxisome proliferator activated receptor (PPAR)α agonist fenofibrate and the PPARγ agonist pioglitazone
by: Nordsletten Lars, et al.
Published: (2009-03-01)

The dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist tirzepatide: a novel cardiometabolic therapeutic prospect
by: Enrique Z. Fisman, et al.
Published: (2021-11-01)

Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)
by: Yuan-Ye Qiu, et al.
Published: (2023-06-01)

The effects of gemfibrozil and ovariectomy on the peroxisome proliferator activated receptors (ppars) in mice with experimentally induced obesity
by: TUNCA R, et al.
Published: (2013-09-01)

Synthetic and natural Peroxisome Proliferator-Activated Receptor (PPAR) agonists as candidates for the therapy of the metabolic syndrome
by: Tan, Chek Kun, et al.
Published: (2017)

Peroxisome Proliferators Activated Receptor (PPAR) agonists activate hepatitis B virus replication in vivo
by: Lingyao Du, et al.
Published: (2017-05-01)

Glycogen content regulates peroxisome proliferator activated receptor-∂ (PPAR-∂) activity in rat skeletal muscle.
by: Andrew Philp, et al.
Published: (2013-01-01)

Evaluation of the Relationship between Peroxisome Proliferator Receptors (PPARα, PPARγ, and PPARδ) Expression and Carcinoembryonic Antigen (CEA) in Patients with Colorectal Cancer
by: Musa Yaghoubizadeh, et al.
Published: (2022-08-01)

Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism
by: Fernando Lizcano, et al.
Published: (2013-01-01)

Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism
by: Fernando Lizcano, et al.
Published: (2013-01-01)

Peroxisome proliferator-activated receptors-γ and hypertension: Lessons of the history of researches
by: M S Rasin
Published: (2013-09-01)

The function of peroxisome proliferator-activated receptors PPAR-γ and PPAR-δ in Mycobacterium leprae-induced foam cell formation in host macrophages.
by: Yuqian Luo, et al.
Published: (2020-10-01)

Effects of peroxisome proliferator activated receptors (PPAR)-γ and -α agonists on cochlear protection from oxidative stress.
by: Marijana Sekulic-Jablanovic, et al.
Published: (2017-01-01)

Bioinformatics analysis reveals the changes of peroxisome proliferator-activated receptor (PPAR) pathway in the development of Marjolin ulcers
by: Cheng Wang, et al.
Published: (2022-12-01)

Molecular Modeling of Allosteric Site of Isoform-Specific Inhibition of the Peroxisome Proliferator-Activated Receptor PPARγ
by: Suliman Almahmoud, et al.
Published: (2022-11-01)

The involvement of peroxisome proliferator-activated receptor gamma (PPARγ) in anti-inflammatory activity of N-stearoylethanolamine
by: H. Kosiakova, et al.
Published: (2022-11-01)

Targeting Peroxisome Proliferator Activated Receptor α (PPAR α) for the Prevention of Mitochondrial Impairment and Hypertrophy in Cardiomyocytes
by: Dipak Kar, et al.
Published: (2018-08-01)

Initiation of the expression of peroxisome proliferator - activated receptor gamma (PPAR gamma) in the rat ovary and the role of FSH
by: Sairam M Ram, et al.
Published: (2009-12-01)

Impaired T cell-mediated hepatitis in peroxisome proliferator activated receptor alpha (PPARα)-deficient mice
by: Ian N. Hines, et al.
Published: (2018-02-01)