The host cellular immune response to cytomegalovirus targets the endothelium and is associated with increased arterial stiffness in ANCA-associated vasculitis

The host cellular immune response to cytomegalovirus targets the endothelium and is associated with increased arterial stiffness in ANCA-associated vasculitis

Abstract Background Cardiovascular disease is a leading cause of death in ANCA-associated vasculitis (AAV). An expansion of CD4+CD28null T cells is seen mainly in cytomegalovirus (CMV)-seropositive individuals and has been linked to increased cardiovascular disease risk in other conditions. The aims...

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Bibliographic Details
Main Authors: Dimitrios Chanouzas, Michael Sagmeister, Lovesh Dyall, Phoebe Sharp, Lucy Powley, Serena Johal, Jessica Bowen, Peter Nightingale, Charles J. Ferro, Matthew D. Morgan, Paul Moss, Lorraine Harper
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Arthritis Research & Therapy
Subjects:
ANCA
Vasculitis
Cytomegalovirus
Inflammation
T cells
Arterial stiffness
Online Access:http://link.springer.com/article/10.1186/s13075-018-1695-8

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