Bile acids, gut microbiota and metabolic surgery
Metabolic surgery, or bariatric surgery, is currently the most effective approach for treating obesity and its complications. Vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) are the top two types of commonly performed metabolic surgery now. The precise mechanisms of how the sur...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.929530/full |
| _version_ | 1828356695245455360 |
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| author | Jui Tu Jui Tu Yangmeng Wang Lihua Jin Wendong Huang Wendong Huang |
| author_facet | Jui Tu Jui Tu Yangmeng Wang Lihua Jin Wendong Huang Wendong Huang |
| author_sort | Jui Tu |
| collection | DOAJ |
| description | Metabolic surgery, or bariatric surgery, is currently the most effective approach for treating obesity and its complications. Vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) are the top two types of commonly performed metabolic surgery now. The precise mechanisms of how the surgeries work are still unclear, therefore much research has been conducted in this area. Gut hormones such as GLP-1 and PYY have been studied extensively in the context of metabolic surgery because they both participate in satiety and glucose homeostasis. Bile acids, whose functions cover intestinal lipid absorption and various aspects of metabolic regulation via the action of FXR, TGR5, and other bile acid receptors, have also been actively investigated as potential mediators of metabolic surgery. Additionally, gut microbiota and their metabolites have also been studied because they can affect metabolic health. The current review summarizes and compares the recent scientific progress made on identifying the mechanisms of RYGB and VSG. One of the long-term goals of metabolic/bariatric surgery research is to develop new pharmacotherapeutic options for the treatment of obesity and diabetes. Because obesity is a growing health concern worldwide, there is a dire need in developing novel non-invasive treatment options. |
| first_indexed | 2024-04-14T03:04:09Z |
| format | Article |
| id | doaj.art-b41c0adbe4f441e5a92c5763c07e0602 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-14T03:04:09Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-b41c0adbe4f441e5a92c5763c07e06022022-12-22T02:15:50ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-08-011310.3389/fendo.2022.929530929530Bile acids, gut microbiota and metabolic surgeryJui Tu0Jui Tu1Yangmeng Wang2Lihua Jin3Wendong Huang4Wendong Huang5Department of Diabetes Complications and Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, United StatesIrell & Manella Graduate School of Biomedical Science, City of Hope National Medical Center, Duarte, CA, United StatesDepartment of Diabetes Complications and Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, United StatesDepartment of Diabetes Complications and Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, United StatesDepartment of Diabetes Complications and Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, United StatesIrell & Manella Graduate School of Biomedical Science, City of Hope National Medical Center, Duarte, CA, United StatesMetabolic surgery, or bariatric surgery, is currently the most effective approach for treating obesity and its complications. Vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) are the top two types of commonly performed metabolic surgery now. The precise mechanisms of how the surgeries work are still unclear, therefore much research has been conducted in this area. Gut hormones such as GLP-1 and PYY have been studied extensively in the context of metabolic surgery because they both participate in satiety and glucose homeostasis. Bile acids, whose functions cover intestinal lipid absorption and various aspects of metabolic regulation via the action of FXR, TGR5, and other bile acid receptors, have also been actively investigated as potential mediators of metabolic surgery. Additionally, gut microbiota and their metabolites have also been studied because they can affect metabolic health. The current review summarizes and compares the recent scientific progress made on identifying the mechanisms of RYGB and VSG. One of the long-term goals of metabolic/bariatric surgery research is to develop new pharmacotherapeutic options for the treatment of obesity and diabetes. Because obesity is a growing health concern worldwide, there is a dire need in developing novel non-invasive treatment options.https://www.frontiersin.org/articles/10.3389/fendo.2022.929530/fullbile acidgut microbiotametabolic surgeryobesitydiabetesbariatric surgery |
| spellingShingle | Jui Tu Jui Tu Yangmeng Wang Lihua Jin Wendong Huang Wendong Huang Bile acids, gut microbiota and metabolic surgery Frontiers in Endocrinology bile acid gut microbiota metabolic surgery obesity diabetes bariatric surgery |
| title | Bile acids, gut microbiota and metabolic surgery |
| title_full | Bile acids, gut microbiota and metabolic surgery |
| title_fullStr | Bile acids, gut microbiota and metabolic surgery |
| title_full_unstemmed | Bile acids, gut microbiota and metabolic surgery |
| title_short | Bile acids, gut microbiota and metabolic surgery |
| title_sort | bile acids gut microbiota and metabolic surgery |
| topic | bile acid gut microbiota metabolic surgery obesity diabetes bariatric surgery |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.929530/full |
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