Research progress in the relationship between mitochondrial dysfunction and osteoporosis
Osteoporosis (OP) is a chronic senile bone disease characterized by decreased bone mass and increased bone fragility. There are many inducing factors and the pathogenesis is complex. To explore the mechanism of OP and improve clinical efficacy has always been a hot topic in life science. In recent y...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science)
2023-06-01
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| Series: | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| Subjects: | |
| Online Access: | https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-6-761.shtml |
| _version_ | 1797304022524231680 |
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| author | JIN Fangquan FAN Chenghu TANG Xiaodong CHEN Yantong QI Bingxian |
| author_facet | JIN Fangquan FAN Chenghu TANG Xiaodong CHEN Yantong QI Bingxian |
| author_sort | JIN Fangquan |
| collection | DOAJ |
| description | Osteoporosis (OP) is a chronic senile bone disease characterized by decreased bone mass and increased bone fragility. There are many inducing factors and the pathogenesis is complex. To explore the mechanism of OP and improve clinical efficacy has always been a hot topic in life science. In recent years, it has been found that mitochondria play an important role in the pathogenesis of OP. Functional abnormalities such as mitochondrial energy metabolism, mitochondrial oxidative stress, mitochondrial autophagy, mitochondrial-mediated apoptosis and mitochondrial dynamics can interfere with the differentiation of bone marrow mesenchymal stem cells through different signal pathways, cytokines and protein expression to regulate osteoblast activity, proliferation and differentiation, and start the process of osteoclast apoptosis. Therefore, taking mitochondria as the target, regulating the functions of mitochondrial energy metabolism, oxidative stress, autophagy and kinetics, inducing osteogenic differentiation of bone marrow mesenchymal stem cells, promoting osteoblast differentiation and mineralization, and inducing osteoclast apoptosis are potential strategies for the prevention and treatment of OP. In this article, the mechanism of mitochondrial dysfunction in OP was reviewed by referring to relevant literature at home and abroad, in order to lay a foundation for further research. |
| first_indexed | 2024-03-08T00:02:19Z |
| format | Article |
| id | doaj.art-b41d3a874de5430cbc3e158091daf45d |
| institution | Directory Open Access Journal |
| issn | 1674-8115 |
| language | zho |
| last_indexed | 2024-03-08T00:02:19Z |
| publishDate | 2023-06-01 |
| publisher | Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) |
| record_format | Article |
| series | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| spelling | doaj.art-b41d3a874de5430cbc3e158091daf45d2024-02-18T02:19:54ZzhoEditorial Office of Journal of Shanghai Jiao Tong University (Medical Science)Shanghai Jiaotong Daxue xuebao. Yixue ban1674-81152023-06-0143676176710.3969/j.issn.1674-8115.2023.06.0131674-8115（2023）06-0761-07Research progress in the relationship between mitochondrial dysfunction and osteoporosisJIN Fangquan0FAN Chenghu1TANG Xiaodong2CHEN Yantong3QI Bingxian4Clinical College of Chinese Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730030Gansu Provincial Hospital of Traditional Chinese Medicine Spine Center, Lanzhou 730050Gansu Provincial Hospital of Traditional Chinese Medicine Spine Center, Lanzhou 730050Gansu Provincial Hospital of Traditional Chinese Medicine Spine Center, Lanzhou 730050Gansu Provincial Hospital of Traditional Chinese Medicine Spine Center, Lanzhou 730050Osteoporosis (OP) is a chronic senile bone disease characterized by decreased bone mass and increased bone fragility. There are many inducing factors and the pathogenesis is complex. To explore the mechanism of OP and improve clinical efficacy has always been a hot topic in life science. In recent years, it has been found that mitochondria play an important role in the pathogenesis of OP. Functional abnormalities such as mitochondrial energy metabolism, mitochondrial oxidative stress, mitochondrial autophagy, mitochondrial-mediated apoptosis and mitochondrial dynamics can interfere with the differentiation of bone marrow mesenchymal stem cells through different signal pathways, cytokines and protein expression to regulate osteoblast activity, proliferation and differentiation, and start the process of osteoclast apoptosis. Therefore, taking mitochondria as the target, regulating the functions of mitochondrial energy metabolism, oxidative stress, autophagy and kinetics, inducing osteogenic differentiation of bone marrow mesenchymal stem cells, promoting osteoblast differentiation and mineralization, and inducing osteoclast apoptosis are potential strategies for the prevention and treatment of OP. In this article, the mechanism of mitochondrial dysfunction in OP was reviewed by referring to relevant literature at home and abroad, in order to lay a foundation for further research.https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-6-761.shtmlmitochondriaosteoporosisoxidative stressautophagymitochondrial dynamics |
| spellingShingle | JIN Fangquan FAN Chenghu TANG Xiaodong CHEN Yantong QI Bingxian Research progress in the relationship between mitochondrial dysfunction and osteoporosis Shanghai Jiaotong Daxue xuebao. Yixue ban mitochondria osteoporosis oxidative stress autophagy mitochondrial dynamics |
| title | Research progress in the relationship between mitochondrial dysfunction and osteoporosis |
| title_full | Research progress in the relationship between mitochondrial dysfunction and osteoporosis |
| title_fullStr | Research progress in the relationship between mitochondrial dysfunction and osteoporosis |
| title_full_unstemmed | Research progress in the relationship between mitochondrial dysfunction and osteoporosis |
| title_short | Research progress in the relationship between mitochondrial dysfunction and osteoporosis |
| title_sort | research progress in the relationship between mitochondrial dysfunction and osteoporosis |
| topic | mitochondria osteoporosis oxidative stress autophagy mitochondrial dynamics |
| url | https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-6-761.shtml |
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