Bowel preparation using 2-L split-dose polyethylene glycol regimen plus lubiprostone versus 4-L split-dose polyethylene glycol regimen: a randomized controlled trial
Abstract Background Colonoscopy is a standard procedure for evaluating colon diseases and screening for colorectal cancer, and bowel cleanliness prior to colonoscopy is key. The aim of this study was to compare the bowel cleansing efficacy of low-volume (2 L) split-dose polyethylene glycol (PEG) plu...
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12876-022-02497-2 |
| _version_ | 1798000671031558144 |
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| author | Apichet Sirinawasatien Pallop Sakulthongthawin Kanokpoj Chanpiwat Tanyaporn Chantarojanasiri |
| author_facet | Apichet Sirinawasatien Pallop Sakulthongthawin Kanokpoj Chanpiwat Tanyaporn Chantarojanasiri |
| author_sort | Apichet Sirinawasatien |
| collection | DOAJ |
| description | Abstract Background Colonoscopy is a standard procedure for evaluating colon diseases and screening for colorectal cancer, and bowel cleanliness prior to colonoscopy is key. The aim of this study was to compare the bowel cleansing efficacy of low-volume (2 L) split-dose polyethylene glycol (PEG) plus single-dose (24 µg) lubiprostone (LB) and high-volume (4 L) split-dose PEG. Methods Patients scheduled to undergo outpatient colonoscopy between December 2019 and June 2021 at Rajavithi Hospital were enrolled and randomized into two groups: 2 L PEG + LB or 4 L PEG. Colon cleanliness was evaluated using the Boston Bowel Preparation Scale (BBPS) by reviewing images of the colon after completion of colonoscopy. Secondary outcomes comprised cecal intubation rate, procedure time, withdrawal time, polyp detection rate, adenoma detection rate, patient satisfaction, compliance (based on complete ingestion of bowel preparation regimen), willingness to repeat the preparation regimen, and associated adverse events. Results One hundred and forty patients were included, with 70 in each group. The mean total and segment-specific BBPS scores were not significantly different between groups. However, the rate of adequate bowel preparation was significantly higher in the 2 L PEG + LB group than the 4 L PEG group (100% [95% CI 94.6–100] versus 88.4% [95% CI 78.4–94.9], p = 0.004) in the per-protocol analysis. Colonic polyps were the most common finding. The polyp detection rate, adenoma detection rate, and all secondary outcomes were statistically similar in the two groups (p > 0.05). Conclusions The combination of 2 L split-dose PEG plus LB improves bowel cleanliness (based on BBPS scores) to a comparable degree to the standard 4 L split-dose PEG, without additional adverse events and with a lower PEG volume. |
| first_indexed | 2024-04-11T11:24:03Z |
| format | Article |
| id | doaj.art-b41dd67540e84d34887590c83eda26ad |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-04-11T11:24:03Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-b41dd67540e84d34887590c83eda26ad2022-12-22T04:26:21ZengBMCBMC Gastroenterology1471-230X2022-09-012211910.1186/s12876-022-02497-2Bowel preparation using 2-L split-dose polyethylene glycol regimen plus lubiprostone versus 4-L split-dose polyethylene glycol regimen: a randomized controlled trialApichet Sirinawasatien0Pallop Sakulthongthawin1Kanokpoj Chanpiwat2Tanyaporn Chantarojanasiri3Division of Gastroenterology, Department of Medicine, Rajavithi Hospital, College of Medicine, Rangsit UniversityDepartment of Internal Medicine, Chaophraya Abhaibhubejhr Hospital, Tha Ngam Sub-DistrictDivision of Gastroenterology, Department of Medicine, Rajavithi Hospital, College of Medicine, Rangsit UniversityDivision of Gastroenterology, Department of Medicine, Rajavithi Hospital, College of Medicine, Rangsit UniversityAbstract Background Colonoscopy is a standard procedure for evaluating colon diseases and screening for colorectal cancer, and bowel cleanliness prior to colonoscopy is key. The aim of this study was to compare the bowel cleansing efficacy of low-volume (2 L) split-dose polyethylene glycol (PEG) plus single-dose (24 µg) lubiprostone (LB) and high-volume (4 L) split-dose PEG. Methods Patients scheduled to undergo outpatient colonoscopy between December 2019 and June 2021 at Rajavithi Hospital were enrolled and randomized into two groups: 2 L PEG + LB or 4 L PEG. Colon cleanliness was evaluated using the Boston Bowel Preparation Scale (BBPS) by reviewing images of the colon after completion of colonoscopy. Secondary outcomes comprised cecal intubation rate, procedure time, withdrawal time, polyp detection rate, adenoma detection rate, patient satisfaction, compliance (based on complete ingestion of bowel preparation regimen), willingness to repeat the preparation regimen, and associated adverse events. Results One hundred and forty patients were included, with 70 in each group. The mean total and segment-specific BBPS scores were not significantly different between groups. However, the rate of adequate bowel preparation was significantly higher in the 2 L PEG + LB group than the 4 L PEG group (100% [95% CI 94.6–100] versus 88.4% [95% CI 78.4–94.9], p = 0.004) in the per-protocol analysis. Colonic polyps were the most common finding. The polyp detection rate, adenoma detection rate, and all secondary outcomes were statistically similar in the two groups (p > 0.05). Conclusions The combination of 2 L split-dose PEG plus LB improves bowel cleanliness (based on BBPS scores) to a comparable degree to the standard 4 L split-dose PEG, without additional adverse events and with a lower PEG volume.https://doi.org/10.1186/s12876-022-02497-2ColonoscopyBowel preparationLubiprostonePolyethylene glycolBoston Bowel Preparation Scale |
| spellingShingle | Apichet Sirinawasatien Pallop Sakulthongthawin Kanokpoj Chanpiwat Tanyaporn Chantarojanasiri Bowel preparation using 2-L split-dose polyethylene glycol regimen plus lubiprostone versus 4-L split-dose polyethylene glycol regimen: a randomized controlled trial BMC Gastroenterology Colonoscopy Bowel preparation Lubiprostone Polyethylene glycol Boston Bowel Preparation Scale |
| title | Bowel preparation using 2-L split-dose polyethylene glycol regimen plus lubiprostone versus 4-L split-dose polyethylene glycol regimen: a randomized controlled trial |
| title_full | Bowel preparation using 2-L split-dose polyethylene glycol regimen plus lubiprostone versus 4-L split-dose polyethylene glycol regimen: a randomized controlled trial |
| title_fullStr | Bowel preparation using 2-L split-dose polyethylene glycol regimen plus lubiprostone versus 4-L split-dose polyethylene glycol regimen: a randomized controlled trial |
| title_full_unstemmed | Bowel preparation using 2-L split-dose polyethylene glycol regimen plus lubiprostone versus 4-L split-dose polyethylene glycol regimen: a randomized controlled trial |
| title_short | Bowel preparation using 2-L split-dose polyethylene glycol regimen plus lubiprostone versus 4-L split-dose polyethylene glycol regimen: a randomized controlled trial |
| title_sort | bowel preparation using 2 l split dose polyethylene glycol regimen plus lubiprostone versus 4 l split dose polyethylene glycol regimen a randomized controlled trial |
| topic | Colonoscopy Bowel preparation Lubiprostone Polyethylene glycol Boston Bowel Preparation Scale |
| url | https://doi.org/10.1186/s12876-022-02497-2 |
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