Cancer Metabostemness and Metabolic Reprogramming via P2X7 Receptor
The heterogeneity of tumor cell mass and the plasticity of cancer cell phenotypes in solid tumors allow for the insurgence of resistant and metastatic cells, responsible for cancer patients’ clinical management’s main challenges. Among several factors that are responsible for increased cancer aggres...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/7/1782 |
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| author | Izadora Lorrany Alves Rabelo Vanessa Fernandes Arnaud-Sampaio Elena Adinolfi Henning Ulrich Claudiana Lameu |
| author_facet | Izadora Lorrany Alves Rabelo Vanessa Fernandes Arnaud-Sampaio Elena Adinolfi Henning Ulrich Claudiana Lameu |
| author_sort | Izadora Lorrany Alves Rabelo |
| collection | DOAJ |
| description | The heterogeneity of tumor cell mass and the plasticity of cancer cell phenotypes in solid tumors allow for the insurgence of resistant and metastatic cells, responsible for cancer patients’ clinical management’s main challenges. Among several factors that are responsible for increased cancer aggression, metabolic reprogramming is recently emerging as an ultimate cancer hallmark, as it is central for cancer cell survival and self-renewal, metastasis and chemoresistance. The P2X7 receptor, whose expression is upregulated in many solid and hematological malignancies, is also emerging as a good candidate in cancer metabolic reprogramming and the regulation of stem cell proliferation and differentiation. Metabostemness refers to the metabolic reprogramming of cancer cells toward less differentiated (CSCs) cellular states, and we believe that there is a strong correlation between metabostemness and P2X7 receptor functions in oncogenic processes. Here, we summarize important aspects of P2X7 receptor functions in normal and tumor tissues as well as essential aspects of its structure, regulation, pharmacology and its clinical use. Finally, we review current knowledge implicating P2X7 receptor functions in cancer-related molecular pathways, in metabolic reprogramming and in metabostemness. |
| first_indexed | 2024-03-10T09:43:23Z |
| format | Article |
| id | doaj.art-b41e786df50b499980fb9a765e6a4391 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T09:43:23Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-b41e786df50b499980fb9a765e6a43912023-11-22T03:29:59ZengMDPI AGCells2073-44092021-07-01107178210.3390/cells10071782Cancer Metabostemness and Metabolic Reprogramming via P2X7 ReceptorIzadora Lorrany Alves Rabelo0Vanessa Fernandes Arnaud-Sampaio1Elena Adinolfi2Henning Ulrich3Claudiana Lameu4Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05508-000, BrazilDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05508-000, BrazilDepartment of Medical Sciences, Section of Experimental Medicine, University of Ferrara, 44121 Ferrara, ItalyDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05508-000, BrazilDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05508-000, BrazilThe heterogeneity of tumor cell mass and the plasticity of cancer cell phenotypes in solid tumors allow for the insurgence of resistant and metastatic cells, responsible for cancer patients’ clinical management’s main challenges. Among several factors that are responsible for increased cancer aggression, metabolic reprogramming is recently emerging as an ultimate cancer hallmark, as it is central for cancer cell survival and self-renewal, metastasis and chemoresistance. The P2X7 receptor, whose expression is upregulated in many solid and hematological malignancies, is also emerging as a good candidate in cancer metabolic reprogramming and the regulation of stem cell proliferation and differentiation. Metabostemness refers to the metabolic reprogramming of cancer cells toward less differentiated (CSCs) cellular states, and we believe that there is a strong correlation between metabostemness and P2X7 receptor functions in oncogenic processes. Here, we summarize important aspects of P2X7 receptor functions in normal and tumor tissues as well as essential aspects of its structure, regulation, pharmacology and its clinical use. Finally, we review current knowledge implicating P2X7 receptor functions in cancer-related molecular pathways, in metabolic reprogramming and in metabostemness.https://www.mdpi.com/2073-4409/10/7/1782cancer stem cellsstemnessP2X7 receptorP2X7AP2X7Bpurinergic signaling |
| spellingShingle | Izadora Lorrany Alves Rabelo Vanessa Fernandes Arnaud-Sampaio Elena Adinolfi Henning Ulrich Claudiana Lameu Cancer Metabostemness and Metabolic Reprogramming via P2X7 Receptor Cells cancer stem cells stemness P2X7 receptor P2X7A P2X7B purinergic signaling |
| title | Cancer Metabostemness and Metabolic Reprogramming via P2X7 Receptor |
| title_full | Cancer Metabostemness and Metabolic Reprogramming via P2X7 Receptor |
| title_fullStr | Cancer Metabostemness and Metabolic Reprogramming via P2X7 Receptor |
| title_full_unstemmed | Cancer Metabostemness and Metabolic Reprogramming via P2X7 Receptor |
| title_short | Cancer Metabostemness and Metabolic Reprogramming via P2X7 Receptor |
| title_sort | cancer metabostemness and metabolic reprogramming via p2x7 receptor |
| topic | cancer stem cells stemness P2X7 receptor P2X7A P2X7B purinergic signaling |
| url | https://www.mdpi.com/2073-4409/10/7/1782 |
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