Pediatric-Inspired Regimens in the Treatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults: A Systematic Review
Adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) have significantly worse outcomes than their younger counterparts. Current treatment guidelines rely mostly on non-randomized retrospective studies. We performed a systematic review of studies published within the last 15 yea...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/30/9/625 |
| _version_ | 1827726628907646976 |
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| author | Aida Zeckanovic Philipp Fuchs Philip Heesen Nicole Bodmer Maria Otth Katrin Scheinemann |
| author_facet | Aida Zeckanovic Philipp Fuchs Philip Heesen Nicole Bodmer Maria Otth Katrin Scheinemann |
| author_sort | Aida Zeckanovic |
| collection | DOAJ |
| description | Adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) have significantly worse outcomes than their younger counterparts. Current treatment guidelines rely mostly on non-randomized retrospective studies. We performed a systematic review of studies published within the last 15 years comparing pediatric-inspired regimens (PIR) versus adult-type regimens or performing an age-stratified analysis of outcomes in the AYA population. Due to the heterogeneity of data, a meta-analysis was not possible. However, the gathered data show a trend toward improvement in outcomes and an acceptable toxicity profile in patients treated with PIRs compared to conventional adult-type regimens. There is still room for further improvement, as older patients within the AYA population tend to perform poorly with PIR or conventional adult-type chemotherapy. Further randomized studies are needed to develop an optimal treatment strategy for AYA with ALL. |
| first_indexed | 2024-03-10T22:53:30Z |
| format | Article |
| id | doaj.art-b41efba0cf1945349df9f1f802160b9f |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-10T22:53:30Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-b41efba0cf1945349df9f1f802160b9f2023-11-19T10:11:25ZengMDPI AGCurrent Oncology1198-00521718-77292023-09-013098612863210.3390/curroncol30090625Pediatric-Inspired Regimens in the Treatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults: A Systematic ReviewAida Zeckanovic0Philipp Fuchs1Philip Heesen2Nicole Bodmer3Maria Otth4Katrin Scheinemann5Department of Oncology, University Children’s Hospital Zurich, 8032 Zurich, SwitzerlandDepartment of Oncology, University Children’s Hospital Zurich, 8032 Zurich, SwitzerlandFaculty of Medicine, University of Zurich, 8006 Zurich, SwitzerlandDepartment of Oncology, University Children’s Hospital Zurich, 8032 Zurich, SwitzerlandDepartment of Oncology, University Children’s Hospital Zurich, 8032 Zurich, SwitzerlandDivision of Hematology/Oncology, Children’s Hospital of Eastern Switzerland, 9006 St. Gallen, SwitzerlandAdolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) have significantly worse outcomes than their younger counterparts. Current treatment guidelines rely mostly on non-randomized retrospective studies. We performed a systematic review of studies published within the last 15 years comparing pediatric-inspired regimens (PIR) versus adult-type regimens or performing an age-stratified analysis of outcomes in the AYA population. Due to the heterogeneity of data, a meta-analysis was not possible. However, the gathered data show a trend toward improvement in outcomes and an acceptable toxicity profile in patients treated with PIRs compared to conventional adult-type regimens. There is still room for further improvement, as older patients within the AYA population tend to perform poorly with PIR or conventional adult-type chemotherapy. Further randomized studies are needed to develop an optimal treatment strategy for AYA with ALL.https://www.mdpi.com/1718-7729/30/9/625acute lymphoblastic leukemiaadolescents and young adultprotocolpediatric-inspiredsurvival |
| spellingShingle | Aida Zeckanovic Philipp Fuchs Philip Heesen Nicole Bodmer Maria Otth Katrin Scheinemann Pediatric-Inspired Regimens in the Treatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults: A Systematic Review Current Oncology acute lymphoblastic leukemia adolescents and young adult protocol pediatric-inspired survival |
| title | Pediatric-Inspired Regimens in the Treatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults: A Systematic Review |
| title_full | Pediatric-Inspired Regimens in the Treatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults: A Systematic Review |
| title_fullStr | Pediatric-Inspired Regimens in the Treatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults: A Systematic Review |
| title_full_unstemmed | Pediatric-Inspired Regimens in the Treatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults: A Systematic Review |
| title_short | Pediatric-Inspired Regimens in the Treatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults: A Systematic Review |
| title_sort | pediatric inspired regimens in the treatment of acute lymphoblastic leukemia in adolescents and young adults a systematic review |
| topic | acute lymphoblastic leukemia adolescents and young adult protocol pediatric-inspired survival |
| url | https://www.mdpi.com/1718-7729/30/9/625 |
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