Serum endocan and endothelial dysfunction in childhood acute lymphoblastic leukemia survivors: a tertiary center experience
Background: An increased risk of cardiovascular complications is reported in survivors of childhood acute lymphoblastic leukemia (ALL). Early identification of impaired vascular health may allow for early interventions to improve outcomes. Aim: The study was conducted to assess the endothelial dysfu...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-05-01
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| Series: | Therapeutic Advances in Chronic Disease |
| Online Access: | https://doi.org/10.1177/20406223211015963 |
| _version_ | 1819135977964175360 |
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| author | Laila M. Sherief Elhamy R. Abd El-khalek Ibrahim A. Libda Osama A. Gaber Naglaa M. Kamal Basma K. Soliman Wesam A. Mokhtar Ghada A. Mokhtar Hosam E. Salah Gehad M. Kamar Marwa Zakaria |
| author_facet | Laila M. Sherief Elhamy R. Abd El-khalek Ibrahim A. Libda Osama A. Gaber Naglaa M. Kamal Basma K. Soliman Wesam A. Mokhtar Ghada A. Mokhtar Hosam E. Salah Gehad M. Kamar Marwa Zakaria |
| author_sort | Laila M. Sherief |
| collection | DOAJ |
| description | Background: An increased risk of cardiovascular complications is reported in survivors of childhood acute lymphoblastic leukemia (ALL). Early identification of impaired vascular health may allow for early interventions to improve outcomes. Aim: The study was conducted to assess the endothelial dysfunction in ALL survivors using a new marker, serum endocan, and measurement of the mean common carotid arteries intima media thickness (cIMT). Methods: A case-control study was conducted on 100 childhood ALL survivors (aged 6–18 years), with 80 healthy age and sex-matched children as a control group. Lipid profile, hepatitis markers, and serum ferritin where measured, in addition to the measurement of serum endocan. and cIMT by B-mode high-resolution ultrasonography for all study participants. Results: Triglycerides, total cholesterol, post prandial glucose, and serum ferritin were significantly higher in ALL survivors than controls ( p < 0.05). Dyslipidemia was detected in 6% of ALL survivors. ALL survivors showed statistically higher serum endocan levels (470.41 ± 556.1 ng/l, versus , 225.94 ± 185.2 ng/l, respectively) and increased cIMT levels compared with the control group (0.650 ± 0.129 mm versus 0.320 ± 0.095 mm, respectively) p < 0.05. Serum endocan was positively correlated with cIMT and blood cholesterol. Conclusions: The survivors of childhood ALL demonstrated an elevated level of serum endocan and increased cIMT. These can be used as predictors of endothelial dysfunction, and, as a consequence, the risk of developing premature atherosclerosis. |
| first_indexed | 2024-12-22T10:27:40Z |
| format | Article |
| id | doaj.art-b423f1d3829545d1976e04e9896dba96 |
| institution | Directory Open Access Journal |
| issn | 2040-6231 |
| language | English |
| last_indexed | 2024-12-22T10:27:40Z |
| publishDate | 2021-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Chronic Disease |
| spelling | doaj.art-b423f1d3829545d1976e04e9896dba962022-12-21T18:29:26ZengSAGE PublishingTherapeutic Advances in Chronic Disease2040-62312021-05-011210.1177/20406223211015963Serum endocan and endothelial dysfunction in childhood acute lymphoblastic leukemia survivors: a tertiary center experienceLaila M. SheriefElhamy R. Abd El-khalekIbrahim A. LibdaOsama A. GaberNaglaa M. KamalBasma K. SolimanWesam A. MokhtarGhada A. MokhtarHosam E. SalahGehad M. KamarMarwa ZakariaBackground: An increased risk of cardiovascular complications is reported in survivors of childhood acute lymphoblastic leukemia (ALL). Early identification of impaired vascular health may allow for early interventions to improve outcomes. Aim: The study was conducted to assess the endothelial dysfunction in ALL survivors using a new marker, serum endocan, and measurement of the mean common carotid arteries intima media thickness (cIMT). Methods: A case-control study was conducted on 100 childhood ALL survivors (aged 6–18 years), with 80 healthy age and sex-matched children as a control group. Lipid profile, hepatitis markers, and serum ferritin where measured, in addition to the measurement of serum endocan. and cIMT by B-mode high-resolution ultrasonography for all study participants. Results: Triglycerides, total cholesterol, post prandial glucose, and serum ferritin were significantly higher in ALL survivors than controls ( p < 0.05). Dyslipidemia was detected in 6% of ALL survivors. ALL survivors showed statistically higher serum endocan levels (470.41 ± 556.1 ng/l, versus , 225.94 ± 185.2 ng/l, respectively) and increased cIMT levels compared with the control group (0.650 ± 0.129 mm versus 0.320 ± 0.095 mm, respectively) p < 0.05. Serum endocan was positively correlated with cIMT and blood cholesterol. Conclusions: The survivors of childhood ALL demonstrated an elevated level of serum endocan and increased cIMT. These can be used as predictors of endothelial dysfunction, and, as a consequence, the risk of developing premature atherosclerosis.https://doi.org/10.1177/20406223211015963 |
| spellingShingle | Laila M. Sherief Elhamy R. Abd El-khalek Ibrahim A. Libda Osama A. Gaber Naglaa M. Kamal Basma K. Soliman Wesam A. Mokhtar Ghada A. Mokhtar Hosam E. Salah Gehad M. Kamar Marwa Zakaria Serum endocan and endothelial dysfunction in childhood acute lymphoblastic leukemia survivors: a tertiary center experience Therapeutic Advances in Chronic Disease |
| title | Serum endocan and endothelial dysfunction in childhood acute lymphoblastic leukemia survivors: a tertiary center experience |
| title_full | Serum endocan and endothelial dysfunction in childhood acute lymphoblastic leukemia survivors: a tertiary center experience |
| title_fullStr | Serum endocan and endothelial dysfunction in childhood acute lymphoblastic leukemia survivors: a tertiary center experience |
| title_full_unstemmed | Serum endocan and endothelial dysfunction in childhood acute lymphoblastic leukemia survivors: a tertiary center experience |
| title_short | Serum endocan and endothelial dysfunction in childhood acute lymphoblastic leukemia survivors: a tertiary center experience |
| title_sort | serum endocan and endothelial dysfunction in childhood acute lymphoblastic leukemia survivors a tertiary center experience |
| url | https://doi.org/10.1177/20406223211015963 |
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