Comparison of the Preemptive Effect of Intravenous Paracetamol and Ketorolac on Prevention of Postoperative Pain in Patients Undergoing Abdominal Surgery
Background: Postoperative pain is one of the most prevalent complications after the surgery and several studies have been performed for prevention of it. This study aimed to compare the preemptive effect of intravenous paracetamol and ketorolac on prevention of postoperative pain in patients undergo...
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Isfahan University of Medical Sciences
2017-10-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/8292 |
| _version_ | 1797763439469264896 |
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| author | Hamid Saryazdi Omid Aghadavoudi Shiva Fakhari |
| author_facet | Hamid Saryazdi Omid Aghadavoudi Shiva Fakhari |
| author_sort | Hamid Saryazdi |
| collection | DOAJ |
| description | Background: Postoperative pain is one of the most prevalent complications after the surgery and several studies have been performed for prevention of it. This study aimed to compare the preemptive effect of intravenous paracetamol and ketorolac on prevention of postoperative pain in patients undergoing abdominal surgeries.
Methods: In a clinical trial study, 80 patients undergoing abdominal surgery were selected and randomly divided into two groups of 40. The first and second groups received 30 mg intravenous paracetamol and 1 g intravenous ketorolac, respectively, one hour before the beginning of surgery. Incidence and intensity of postoperative pain were compared between the two groups.
Findings: The mean score of postoperative pain in paracetamol and ketorolac groups in recovery were 7.4 ± 0.9 and 5.9 ± 2.0, respectively and the difference between the groups was statistically significant (P < 0.001). In addition, postoperative pain intensity in 2, 6, and 18 hours after the surgery was lower in ketorolac group. The mean change of postoperative pain intensity was different in the two groups (P = 0.034). But, the incidence of nausea and vomiting was higher in ketorolac group.
Conclusion: Injection of paracetamol led to more decrease in postoperative pain; but the incidence of postoperative nausea and vomiting was higher with ketorolac. As using non-steroidal anti-inflammatory drugs in some of patients is limited, probably paracetamol is a suitable drug for prevention of postoperative pain. Although, more studies is recommended. |
| first_indexed | 2024-03-12T19:41:37Z |
| format | Article |
| id | doaj.art-b425192931ed416996a2f07a2478fe5e |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T19:41:37Z |
| publishDate | 2017-10-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-b425192931ed416996a2f07a2478fe5e2023-08-02T03:48:35ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2017-10-01354429789852598Comparison of the Preemptive Effect of Intravenous Paracetamol and Ketorolac on Prevention of Postoperative Pain in Patients Undergoing Abdominal SurgeryHamid Saryazdi0Omid Aghadavoudi1Shiva Fakhari2Associate Professor, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, IranStudent of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: Postoperative pain is one of the most prevalent complications after the surgery and several studies have been performed for prevention of it. This study aimed to compare the preemptive effect of intravenous paracetamol and ketorolac on prevention of postoperative pain in patients undergoing abdominal surgeries. Methods: In a clinical trial study, 80 patients undergoing abdominal surgery were selected and randomly divided into two groups of 40. The first and second groups received 30 mg intravenous paracetamol and 1 g intravenous ketorolac, respectively, one hour before the beginning of surgery. Incidence and intensity of postoperative pain were compared between the two groups. Findings: The mean score of postoperative pain in paracetamol and ketorolac groups in recovery were 7.4 ± 0.9 and 5.9 ± 2.0, respectively and the difference between the groups was statistically significant (P < 0.001). In addition, postoperative pain intensity in 2, 6, and 18 hours after the surgery was lower in ketorolac group. The mean change of postoperative pain intensity was different in the two groups (P = 0.034). But, the incidence of nausea and vomiting was higher in ketorolac group. Conclusion: Injection of paracetamol led to more decrease in postoperative pain; but the incidence of postoperative nausea and vomiting was higher with ketorolac. As using non-steroidal anti-inflammatory drugs in some of patients is limited, probably paracetamol is a suitable drug for prevention of postoperative pain. Although, more studies is recommended.http://jims.mui.ac.ir/index.php/jims/article/view/8292Postoperative painParacetamolKetorolac |
| spellingShingle | Hamid Saryazdi Omid Aghadavoudi Shiva Fakhari Comparison of the Preemptive Effect of Intravenous Paracetamol and Ketorolac on Prevention of Postoperative Pain in Patients Undergoing Abdominal Surgery مجله دانشکده پزشکی اصفهان Postoperative pain Paracetamol Ketorolac |
| title | Comparison of the Preemptive Effect of Intravenous Paracetamol and Ketorolac on Prevention of Postoperative Pain in Patients Undergoing Abdominal Surgery |
| title_full | Comparison of the Preemptive Effect of Intravenous Paracetamol and Ketorolac on Prevention of Postoperative Pain in Patients Undergoing Abdominal Surgery |
| title_fullStr | Comparison of the Preemptive Effect of Intravenous Paracetamol and Ketorolac on Prevention of Postoperative Pain in Patients Undergoing Abdominal Surgery |
| title_full_unstemmed | Comparison of the Preemptive Effect of Intravenous Paracetamol and Ketorolac on Prevention of Postoperative Pain in Patients Undergoing Abdominal Surgery |
| title_short | Comparison of the Preemptive Effect of Intravenous Paracetamol and Ketorolac on Prevention of Postoperative Pain in Patients Undergoing Abdominal Surgery |
| title_sort | comparison of the preemptive effect of intravenous paracetamol and ketorolac on prevention of postoperative pain in patients undergoing abdominal surgery |
| topic | Postoperative pain Paracetamol Ketorolac |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/8292 |
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