An Investigation of Glucose-6-phosphate Dehydrogenase Deficiency, Hyper bilirubinemia, and Blood Incompatibility in Newborn Babies
Abstract Background: Glucose-6- phosphate Dehydrogenase enzyme (G6PD) id an enzyme deficiency that id transported inheritably. The lack of this enzyme decreases the energy revival of red blood cells and leads to Hemolysis which is the cause of severe neonatal jaundice. This study aims at investigat...
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| Format: | Article |
| Language: | fas |
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Arak Medical University
2015-04-01
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| Series: | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| Subjects: | |
| Online Access: | http://amuj.arakmu.ac.ir/article-1-3120-en.pdf |
| _version_ | 1819136982132981760 |
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| author | Pirouzi AY Jafari M Khalil Bahmani MK Azadi M Feizabadi MM Afkari A |
| author_facet | Pirouzi AY Jafari M Khalil Bahmani MK Azadi M Feizabadi MM Afkari A |
| author_sort | Pirouzi AY |
| collection | DOAJ |
| description | Abstract
Background: Glucose-6- phosphate Dehydrogenase enzyme (G6PD) id an enzyme deficiency that id transported inheritably. The lack of this enzyme decreases the energy revival of red blood cells and leads to Hemolysis which is the cause of severe neonatal jaundice. This study aims at investigating glucose-6-phosphate dehydrogenase deficiency, hyperbilirubinemia, and blood incompatibility in newborn babies in larestan city, located in south of Fars province, following the newborn screening national plan.
Materials and Methods: this study id a cross-sectional and descriptive study on 12079 newborns in larestan city that referred to the screeing center from the start of 2010 to the end of 2012. The blood samples were taken from the newborns' heels and were evaluated through G6PD tluorescent spot test. They were examined regarding their blood group, hematocrit, hemoglobin, Coombs test, reticulocyte count and bilirubin levels as well as demographic information.
Results: In this research, among the 12079 screened newborns, 2345 ones showed G6PD deficiency with a prevalence of 19.41 which is a high percentage in comparison to those of other cities in Iran. The prevalence of O+ blood group among sick babies and their mothers was significantly higher than of other blood groups. (60% and 56%, respectively). The Hyperbilirubinemia and the indirect coombs tests were positive in 52% and 12% of the sick babies, respectively.
Conclusion: The prevalence percentage of lack of this enzyme in girls of Larestan city is a little higher than in boys, even though since this disease depends on X, it should be more prevalent in boys. |
| first_indexed | 2024-12-22T10:43:37Z |
| format | Article |
| id | doaj.art-b425e95ccf2c4611aa023a5452a6e908 |
| institution | Directory Open Access Journal |
| issn | 1735-5338 2008-644X |
| language | fas |
| last_indexed | 2024-12-22T10:43:37Z |
| publishDate | 2015-04-01 |
| publisher | Arak Medical University |
| record_format | Article |
| series | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| spelling | doaj.art-b425e95ccf2c4611aa023a5452a6e9082022-12-21T18:28:59ZfasArak Medical UniversityMajallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk1735-53382008-644X2015-04-01181715An Investigation of Glucose-6-phosphate Dehydrogenase Deficiency, Hyper bilirubinemia, and Blood Incompatibility in Newborn BabiesPirouzi AY0Jafari M1Khalil Bahmani MK2Azadi M3Feizabadi MM4Afkari A5Gerash University of Medical Sciences, Gerash, IranGerash University of Medical Sciences, Gerash, IranGerash University of Medical Sciences, Gerash, IranGerash University of Medical Sciences, Gerash, IranIran University of Medical Sciences, Tehran, Iran.Department of Microbiology,Young Researchers Club,Jahrom Branch,Islamic Azad University, Jahrom, IranAbstract Background: Glucose-6- phosphate Dehydrogenase enzyme (G6PD) id an enzyme deficiency that id transported inheritably. The lack of this enzyme decreases the energy revival of red blood cells and leads to Hemolysis which is the cause of severe neonatal jaundice. This study aims at investigating glucose-6-phosphate dehydrogenase deficiency, hyperbilirubinemia, and blood incompatibility in newborn babies in larestan city, located in south of Fars province, following the newborn screening national plan. Materials and Methods: this study id a cross-sectional and descriptive study on 12079 newborns in larestan city that referred to the screeing center from the start of 2010 to the end of 2012. The blood samples were taken from the newborns' heels and were evaluated through G6PD tluorescent spot test. They were examined regarding their blood group, hematocrit, hemoglobin, Coombs test, reticulocyte count and bilirubin levels as well as demographic information. Results: In this research, among the 12079 screened newborns, 2345 ones showed G6PD deficiency with a prevalence of 19.41 which is a high percentage in comparison to those of other cities in Iran. The prevalence of O+ blood group among sick babies and their mothers was significantly higher than of other blood groups. (60% and 56%, respectively). The Hyperbilirubinemia and the indirect coombs tests were positive in 52% and 12% of the sick babies, respectively. Conclusion: The prevalence percentage of lack of this enzyme in girls of Larestan city is a little higher than in boys, even though since this disease depends on X, it should be more prevalent in boys.http://amuj.arakmu.ac.ir/article-1-3120-en.pdfGlucose-6-phosphate Dehydrogenase enzymebilirubinemiaRH incompatibility |
| spellingShingle | Pirouzi AY Jafari M Khalil Bahmani MK Azadi M Feizabadi MM Afkari A An Investigation of Glucose-6-phosphate Dehydrogenase Deficiency, Hyper bilirubinemia, and Blood Incompatibility in Newborn Babies Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk Glucose-6-phosphate Dehydrogenase enzyme bilirubinemia RH incompatibility |
| title | An Investigation of Glucose-6-phosphate Dehydrogenase Deficiency, Hyper bilirubinemia, and Blood Incompatibility in Newborn Babies |
| title_full | An Investigation of Glucose-6-phosphate Dehydrogenase Deficiency, Hyper bilirubinemia, and Blood Incompatibility in Newborn Babies |
| title_fullStr | An Investigation of Glucose-6-phosphate Dehydrogenase Deficiency, Hyper bilirubinemia, and Blood Incompatibility in Newborn Babies |
| title_full_unstemmed | An Investigation of Glucose-6-phosphate Dehydrogenase Deficiency, Hyper bilirubinemia, and Blood Incompatibility in Newborn Babies |
| title_short | An Investigation of Glucose-6-phosphate Dehydrogenase Deficiency, Hyper bilirubinemia, and Blood Incompatibility in Newborn Babies |
| title_sort | investigation of glucose 6 phosphate dehydrogenase deficiency hyper bilirubinemia and blood incompatibility in newborn babies |
| topic | Glucose-6-phosphate Dehydrogenase enzyme bilirubinemia RH incompatibility |
| url | http://amuj.arakmu.ac.ir/article-1-3120-en.pdf |
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