Evaluation of Serum Albumin-Coated Bone Allograft for Bone Regeneration: A Seven-Year Follow-Up Study of 26 Cases
We have previously reported that serum albumin-coated bone allograft (BoneAlbumin, BA) is an effective bone substitute. It improves bone regeneration at the patellar and tibial donor sites six months after harvesting bone-patellar tendon-bone (BPTB) autografts for primary anterior cruciate ligament...
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| Format: | Article |
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/11/9232 |
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| author | Kata K. Gyulay Péter Karászi Mátyás Rédei Petra Sólymos Károly Schandl Zsombor Lacza Dénes B. Horváthy |
| author_facet | Kata K. Gyulay Péter Karászi Mátyás Rédei Petra Sólymos Károly Schandl Zsombor Lacza Dénes B. Horváthy |
| author_sort | Kata K. Gyulay |
| collection | DOAJ |
| description | We have previously reported that serum albumin-coated bone allograft (BoneAlbumin, BA) is an effective bone substitute. It improves bone regeneration at the patellar and tibial donor sites six months after harvesting bone-patellar tendon-bone (BPTB) autografts for primary anterior cruciate ligament reconstruction (ACLR). In the present study, we examined these donor sites seven years after implantation. The study group (N = 10) received BA-enhanced autologous cancellous bone at the tibial and BA alone at the patellar site. The control group (N = 16) received autologous cancellous bone at the tibial and blood clot at the patellar site. We evaluated subcortical density, cortical thickness, and bone defect volume via CT scans. At the patellar site, subcortical density was significantly higher in the BA group at both time points. There was no significant difference in cortical thickness between the two groups at either donor site. The control group’s bone defect significantly improved and reached the BA group’s values at both sites by year seven. Meanwhile, the bone defects in the BA group did not change significantly and were comparable to the six-month measurements. No complications were observed. There are two limitations in this study: The number of patients recruited is small, and the randomization of the patients could have improved the quality of the study as the control group patients were older compared to the study group patients. Our 7-year results seem to demonstrate that BA is a safe and effective bone substitute that supports faster regeneration of donor sites and results in good-quality bone tissue at the time of ACLR with BPTB autografts. However, studies with a larger number of patients are required to definitively confirm the preliminary results of our study. |
| first_indexed | 2024-03-11T03:06:54Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:06:54Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b42a424c2bfc4314af29bb6597e714092023-11-18T07:56:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012411923210.3390/ijms24119232Evaluation of Serum Albumin-Coated Bone Allograft for Bone Regeneration: A Seven-Year Follow-Up Study of 26 CasesKata K. Gyulay0Péter Karászi1Mátyás Rédei2Petra Sólymos3Károly Schandl4Zsombor Lacza5Dénes B. Horváthy6Department of Interventional Radiology, Heart and Vascular Centre, Semmelweis University, 1122 Budapest, HungaryDepartment of Sports Surgery, Saint George University Teaching Hospital of County-Fejér, 8000 Székesfehérvár, HungaryDepartment of Interventional Radiology, Heart and Vascular Centre, Semmelweis University, 1122 Budapest, HungaryDepartment of Interventional Radiology, Heart and Vascular Centre, Semmelweis University, 1122 Budapest, HungaryDepartment of Sports Surgery, Saint George University Teaching Hospital of County-Fejér, 8000 Székesfehérvár, HungaryDepartment of Sports Physiology, University of Physical Education, 1123 Budapest, HungaryDepartment of Interventional Radiology, Heart and Vascular Centre, Semmelweis University, 1122 Budapest, HungaryWe have previously reported that serum albumin-coated bone allograft (BoneAlbumin, BA) is an effective bone substitute. It improves bone regeneration at the patellar and tibial donor sites six months after harvesting bone-patellar tendon-bone (BPTB) autografts for primary anterior cruciate ligament reconstruction (ACLR). In the present study, we examined these donor sites seven years after implantation. The study group (N = 10) received BA-enhanced autologous cancellous bone at the tibial and BA alone at the patellar site. The control group (N = 16) received autologous cancellous bone at the tibial and blood clot at the patellar site. We evaluated subcortical density, cortical thickness, and bone defect volume via CT scans. At the patellar site, subcortical density was significantly higher in the BA group at both time points. There was no significant difference in cortical thickness between the two groups at either donor site. The control group’s bone defect significantly improved and reached the BA group’s values at both sites by year seven. Meanwhile, the bone defects in the BA group did not change significantly and were comparable to the six-month measurements. No complications were observed. There are two limitations in this study: The number of patients recruited is small, and the randomization of the patients could have improved the quality of the study as the control group patients were older compared to the study group patients. Our 7-year results seem to demonstrate that BA is a safe and effective bone substitute that supports faster regeneration of donor sites and results in good-quality bone tissue at the time of ACLR with BPTB autografts. However, studies with a larger number of patients are required to definitively confirm the preliminary results of our study.https://www.mdpi.com/1422-0067/24/11/9232serum albuminbone allograftbone substituteBoneAlbuminbone–tendon–bone autograftBTB |
| spellingShingle | Kata K. Gyulay Péter Karászi Mátyás Rédei Petra Sólymos Károly Schandl Zsombor Lacza Dénes B. Horváthy Evaluation of Serum Albumin-Coated Bone Allograft for Bone Regeneration: A Seven-Year Follow-Up Study of 26 Cases International Journal of Molecular Sciences serum albumin bone allograft bone substitute BoneAlbumin bone–tendon–bone autograft BTB |
| title | Evaluation of Serum Albumin-Coated Bone Allograft for Bone Regeneration: A Seven-Year Follow-Up Study of 26 Cases |
| title_full | Evaluation of Serum Albumin-Coated Bone Allograft for Bone Regeneration: A Seven-Year Follow-Up Study of 26 Cases |
| title_fullStr | Evaluation of Serum Albumin-Coated Bone Allograft for Bone Regeneration: A Seven-Year Follow-Up Study of 26 Cases |
| title_full_unstemmed | Evaluation of Serum Albumin-Coated Bone Allograft for Bone Regeneration: A Seven-Year Follow-Up Study of 26 Cases |
| title_short | Evaluation of Serum Albumin-Coated Bone Allograft for Bone Regeneration: A Seven-Year Follow-Up Study of 26 Cases |
| title_sort | evaluation of serum albumin coated bone allograft for bone regeneration a seven year follow up study of 26 cases |
| topic | serum albumin bone allograft bone substitute BoneAlbumin bone–tendon–bone autograft BTB |
| url | https://www.mdpi.com/1422-0067/24/11/9232 |
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