DGPathinter: a novel model for identifying driver genes via knowledge-driven matrix factorization with prior knowledge from interactome and pathways

Cataloging mutated driver genes that confer a selective growth advantage for tumor cells from sporadic passenger mutations is a critical problem in cancer genomic research. Previous studies have reported that some driver genes are not highly frequently mutated and cannot be tested as statistically s...

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Bibliographic Details
Main Authors: Jianing Xi, Minghui Wang, Ao Li
Format: Article
Language:English
Published: PeerJ Inc. 2017-10-01
Series:PeerJ Computer Science
Subjects:
Online Access:https://peerj.com/articles/cs-133.pdf

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