Effect of Methionine Restriction on Aging: Its Relationship to Oxidative Stress
Enhanced oxidative stress is closely related to aging and impaired metabolic health and is influenced by diet-derived nutrients and energy. Recent studies have shown that methionine restriction (MetR) is related to longevity and metabolic health in organisms from yeast to rodents. The effect of MetR...
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MDPI AG
2021-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/2/130 |
| _version_ | 1797405984952418304 |
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| author | Munehiro Kitada Yoshio Ogura Itaru Monno Jing Xu Daisuke Koya |
| author_facet | Munehiro Kitada Yoshio Ogura Itaru Monno Jing Xu Daisuke Koya |
| author_sort | Munehiro Kitada |
| collection | DOAJ |
| description | Enhanced oxidative stress is closely related to aging and impaired metabolic health and is influenced by diet-derived nutrients and energy. Recent studies have shown that methionine restriction (MetR) is related to longevity and metabolic health in organisms from yeast to rodents. The effect of MetR on lifespan extension and metabolic health is mediated partially through a reduction in oxidative stress. Methionine metabolism is involved in the supply of methyl donors such as S-adenosyl-methionine (SAM), glutathione synthesis and polyamine metabolism. SAM, a methionine metabolite, activates mechanistic target of rapamycin complex 1 and suppresses autophagy; therefore, MetR can induce autophagy. In the process of glutathione synthesis in methionine metabolism, hydrogen sulfide (H<sub>2</sub>S) is produced through cystathionine-β-synthase and cystathionine-γ-lyase; however, MetR can induce increased H<sub>2</sub>S production through this pathway. Similarly, MetR can increase the production of polyamines such as spermidine, which are involved in autophagy. In addition, MetR decreases oxidative stress by inhibiting reactive oxygen species production in mitochondria. Thus, MetR can attenuate oxidative stress through multiple mechanisms, consequently associating with lifespan extension and metabolic health. In this review, we summarize the current understanding of the effects of MetR on lifespan extension and metabolic health, focusing on the reduction in oxidative stress. |
| first_indexed | 2024-03-09T03:18:15Z |
| format | Article |
| id | doaj.art-b42c59cf920f43288c698f2f6fe59ee5 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T03:18:15Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
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| spelling | doaj.art-b42c59cf920f43288c698f2f6fe59ee52023-12-03T15:15:01ZengMDPI AGBiomedicines2227-90592021-01-019213010.3390/biomedicines9020130Effect of Methionine Restriction on Aging: Its Relationship to Oxidative StressMunehiro Kitada0Yoshio Ogura1Itaru Monno2Jing Xu3Daisuke Koya4Department of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, JapanDepartment of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, JapanDepartment of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, JapanDepartment of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, JapanDepartment of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, JapanEnhanced oxidative stress is closely related to aging and impaired metabolic health and is influenced by diet-derived nutrients and energy. Recent studies have shown that methionine restriction (MetR) is related to longevity and metabolic health in organisms from yeast to rodents. The effect of MetR on lifespan extension and metabolic health is mediated partially through a reduction in oxidative stress. Methionine metabolism is involved in the supply of methyl donors such as S-adenosyl-methionine (SAM), glutathione synthesis and polyamine metabolism. SAM, a methionine metabolite, activates mechanistic target of rapamycin complex 1 and suppresses autophagy; therefore, MetR can induce autophagy. In the process of glutathione synthesis in methionine metabolism, hydrogen sulfide (H<sub>2</sub>S) is produced through cystathionine-β-synthase and cystathionine-γ-lyase; however, MetR can induce increased H<sub>2</sub>S production through this pathway. Similarly, MetR can increase the production of polyamines such as spermidine, which are involved in autophagy. In addition, MetR decreases oxidative stress by inhibiting reactive oxygen species production in mitochondria. Thus, MetR can attenuate oxidative stress through multiple mechanisms, consequently associating with lifespan extension and metabolic health. In this review, we summarize the current understanding of the effects of MetR on lifespan extension and metabolic health, focusing on the reduction in oxidative stress.https://www.mdpi.com/2227-9059/9/2/130methionine restrictionoxidative stressautophagylifespan extensionmetabolic health |
| spellingShingle | Munehiro Kitada Yoshio Ogura Itaru Monno Jing Xu Daisuke Koya Effect of Methionine Restriction on Aging: Its Relationship to Oxidative Stress Biomedicines methionine restriction oxidative stress autophagy lifespan extension metabolic health |
| title | Effect of Methionine Restriction on Aging: Its Relationship to Oxidative Stress |
| title_full | Effect of Methionine Restriction on Aging: Its Relationship to Oxidative Stress |
| title_fullStr | Effect of Methionine Restriction on Aging: Its Relationship to Oxidative Stress |
| title_full_unstemmed | Effect of Methionine Restriction on Aging: Its Relationship to Oxidative Stress |
| title_short | Effect of Methionine Restriction on Aging: Its Relationship to Oxidative Stress |
| title_sort | effect of methionine restriction on aging its relationship to oxidative stress |
| topic | methionine restriction oxidative stress autophagy lifespan extension metabolic health |
| url | https://www.mdpi.com/2227-9059/9/2/130 |
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