Functional MRI of emotional memory in adolescent depression
Introduction: Major Depressive Disorder (MDD) is a leading cause of disease burden worldwide. Mood-congruent biases in memory tasks are frequently reported in MDD patients, with facilitated memory for negative stimuli. Most functional MRI studies to date have examined the neural correlates of these...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-06-01
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| Series: | Developmental Cognitive Neuroscience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929315001322 |
| _version_ | 1818847940555309056 |
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| author | Rosemary J. Holt Julia M. Graham Kirstie J. Whitaker Cindy C. Hagan Cinly Ooi Paul O. Wilkinson Adrienne O. van Nieuwenhuizen Belinda R. Lennox Barbara J. Sahakian Ian M. Goodyer Edward T. Bullmore John Suckling |
| author_facet | Rosemary J. Holt Julia M. Graham Kirstie J. Whitaker Cindy C. Hagan Cinly Ooi Paul O. Wilkinson Adrienne O. van Nieuwenhuizen Belinda R. Lennox Barbara J. Sahakian Ian M. Goodyer Edward T. Bullmore John Suckling |
| author_sort | Rosemary J. Holt |
| collection | DOAJ |
| description | Introduction: Major Depressive Disorder (MDD) is a leading cause of disease burden worldwide. Mood-congruent biases in memory tasks are frequently reported in MDD patients, with facilitated memory for negative stimuli. Most functional MRI studies to date have examined the neural correlates of these biases in depressed adults, with fewer studies in adolescents with MDD. Investigation of MDD in adolescence may aid greater understanding of the aetiology and development of the disorder.
Methods: Cognitive biases were investigated in 56 MDD patients aged 11–17 years and a matched group of 30 healthy control participants with a self-referential memory task. Behavioural performance and BOLD fMRI data were collected during both encoding and retrieval stages.
Results: The neural response to encoding in adolescents with MDD was found to differ significantly from controls. Additionally, neural responses during encoding and retrieval showed differential relationships with age between patient and control groups, specifically in medial, temporal, and prefrontal regions.
Conclusions: These findings suggest that during adolescence neurophysiological activity associated with emotional memory differs in those with depression compared to controls and may be age sensitive. |
| first_indexed | 2024-12-19T06:09:26Z |
| format | Article |
| id | doaj.art-b433933663784f3bafb39d14ab2a856f |
| institution | Directory Open Access Journal |
| issn | 1878-9293 1878-9307 |
| language | English |
| last_indexed | 2024-12-19T06:09:26Z |
| publishDate | 2016-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-b433933663784f3bafb39d14ab2a856f2022-12-21T20:33:03ZengElsevierDevelopmental Cognitive Neuroscience1878-92931878-93072016-06-0119C314110.1016/j.dcn.2015.12.013Functional MRI of emotional memory in adolescent depressionRosemary J. Holt0Julia M. Graham1Kirstie J. Whitaker2Cindy C. Hagan3Cinly Ooi4Paul O. Wilkinson5Adrienne O. van Nieuwenhuizen6Belinda R. Lennox7Barbara J. Sahakian8Ian M. Goodyer9Edward T. Bullmore10John Suckling11Department of Psychiatry, University of Cambridge, UKDepartment of Psychiatry, University of Cambridge, UKDepartment of Psychiatry, University of Cambridge, UKDepartment of Psychiatry, University of Cambridge, UKDepartment of Psychiatry, University of Cambridge, UKDepartment of Psychiatry, University of Cambridge, UKCambridge and Peterborough NHS Foundation Trust, UKDepartment of Psychiatry, University of Oxford, UKDepartment of Psychiatry, University of Cambridge, UKDepartment of Psychiatry, University of Cambridge, UKDepartment of Psychiatry, University of Cambridge, UKDepartment of Psychiatry, University of Cambridge, UKIntroduction: Major Depressive Disorder (MDD) is a leading cause of disease burden worldwide. Mood-congruent biases in memory tasks are frequently reported in MDD patients, with facilitated memory for negative stimuli. Most functional MRI studies to date have examined the neural correlates of these biases in depressed adults, with fewer studies in adolescents with MDD. Investigation of MDD in adolescence may aid greater understanding of the aetiology and development of the disorder. Methods: Cognitive biases were investigated in 56 MDD patients aged 11–17 years and a matched group of 30 healthy control participants with a self-referential memory task. Behavioural performance and BOLD fMRI data were collected during both encoding and retrieval stages. Results: The neural response to encoding in adolescents with MDD was found to differ significantly from controls. Additionally, neural responses during encoding and retrieval showed differential relationships with age between patient and control groups, specifically in medial, temporal, and prefrontal regions. Conclusions: These findings suggest that during adolescence neurophysiological activity associated with emotional memory differs in those with depression compared to controls and may be age sensitive.http://www.sciencedirect.com/science/article/pii/S1878929315001322DepressionAdolescenceMemoryfMRIEmotion |
| spellingShingle | Rosemary J. Holt Julia M. Graham Kirstie J. Whitaker Cindy C. Hagan Cinly Ooi Paul O. Wilkinson Adrienne O. van Nieuwenhuizen Belinda R. Lennox Barbara J. Sahakian Ian M. Goodyer Edward T. Bullmore John Suckling Functional MRI of emotional memory in adolescent depression Developmental Cognitive Neuroscience Depression Adolescence Memory fMRI Emotion |
| title | Functional MRI of emotional memory in adolescent depression |
| title_full | Functional MRI of emotional memory in adolescent depression |
| title_fullStr | Functional MRI of emotional memory in adolescent depression |
| title_full_unstemmed | Functional MRI of emotional memory in adolescent depression |
| title_short | Functional MRI of emotional memory in adolescent depression |
| title_sort | functional mri of emotional memory in adolescent depression |
| topic | Depression Adolescence Memory fMRI Emotion |
| url | http://www.sciencedirect.com/science/article/pii/S1878929315001322 |
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