Low-Dose Acetylsalicylic Acid Treatment in Non-Skull-Base Meningiomas: Impact on Tumor Proliferation and Seizure Burden
MIB-1 index is an important predictor of meningioma progression and was found to be correlated with COX-2 expression. However, the impact of low-dose acetylsalicylic acid (ASA) on MIB-1 index and clinical symptoms is unclear. Between 2009 and 2022, 710 patients with clinical data, tumor-imaging data...
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MDPI AG
2022-09-01
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| Online Access: | https://www.mdpi.com/2072-6694/14/17/4285 |
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| author | Johannes Wach Ági Güresir Hartmut Vatter Ulrich Herrlinger Albert Becker Marieta Toma Michael Hölzel Erdem Güresir |
| author_facet | Johannes Wach Ági Güresir Hartmut Vatter Ulrich Herrlinger Albert Becker Marieta Toma Michael Hölzel Erdem Güresir |
| author_sort | Johannes Wach |
| collection | DOAJ |
| description | MIB-1 index is an important predictor of meningioma progression and was found to be correlated with COX-2 expression. However, the impact of low-dose acetylsalicylic acid (ASA) on MIB-1 index and clinical symptoms is unclear. Between 2009 and 2022, 710 patients with clinical data, tumor-imaging data, inflammatory laboratory (plasma fibrinogen, serum C-reactive protein) data, and neuropathological reports underwent surgery for primary cranial WHO grade 1 and 2 meningioma. ASA intake was found to be significantly associated with a low MIB-1 labeling index in female patients ≥ 60 years. Multivariable analysis demonstrated that female patients ≥ 60 years with a non-skull-base meningioma taking ASA had a significantly lower MIB-1 index (OR: 2.6, 95%: 1.0–6.6, <i>p</i> = 0.04). Furthermore, the intake of ASA was independently associated with a reduced burden of symptomatic epilepsy at presentation in non-skull-base meningiomas in both genders (OR: 3.8, 95%CI: 1.3–10.6, <i>p</i> = 0.03). ASA intake might have an anti-proliferative effect in the subgroup of elderly female patients with non-skull-base meningiomas. Furthermore, anti-inflammatory therapy seems to reduce the burden of symptomatic epilepsy in non-skull-base meningiomas. Further research is needed to investigate the role of anti-inflammatory therapy in non-skull-base meningiomas. |
| first_indexed | 2024-03-10T01:58:09Z |
| format | Article |
| id | doaj.art-b433faeadbde4ecc853d68914f8d9dbf |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T01:58:09Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b433faeadbde4ecc853d68914f8d9dbf2023-11-23T12:52:54ZengMDPI AGCancers2072-66942022-09-011417428510.3390/cancers14174285Low-Dose Acetylsalicylic Acid Treatment in Non-Skull-Base Meningiomas: Impact on Tumor Proliferation and Seizure BurdenJohannes Wach0Ági Güresir1Hartmut Vatter2Ulrich Herrlinger3Albert Becker4Marieta Toma5Michael Hölzel6Erdem Güresir7Department of Neurosurgery, University Hospital Bonn, 53127 Bonn, GermanyDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, GermanyDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, GermanyDivision of Clinical Neurooncology, Department of Neurology and Centre of Integrated Oncology, University Hospital Bonn, 53127 Bonn, GermanyDepartment of Neuropathology, University Hospital Bonn, 53127 Bonn, GermanyInstitute of Pathology, University Hospital Bonn, 53127 Bonn, GermanyInstitute of Experimental Oncology, University Hospital Bonn, 53127 Bonn, GermanyDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, GermanyMIB-1 index is an important predictor of meningioma progression and was found to be correlated with COX-2 expression. However, the impact of low-dose acetylsalicylic acid (ASA) on MIB-1 index and clinical symptoms is unclear. Between 2009 and 2022, 710 patients with clinical data, tumor-imaging data, inflammatory laboratory (plasma fibrinogen, serum C-reactive protein) data, and neuropathological reports underwent surgery for primary cranial WHO grade 1 and 2 meningioma. ASA intake was found to be significantly associated with a low MIB-1 labeling index in female patients ≥ 60 years. Multivariable analysis demonstrated that female patients ≥ 60 years with a non-skull-base meningioma taking ASA had a significantly lower MIB-1 index (OR: 2.6, 95%: 1.0–6.6, <i>p</i> = 0.04). Furthermore, the intake of ASA was independently associated with a reduced burden of symptomatic epilepsy at presentation in non-skull-base meningiomas in both genders (OR: 3.8, 95%CI: 1.3–10.6, <i>p</i> = 0.03). ASA intake might have an anti-proliferative effect in the subgroup of elderly female patients with non-skull-base meningiomas. Furthermore, anti-inflammatory therapy seems to reduce the burden of symptomatic epilepsy in non-skull-base meningiomas. Further research is needed to investigate the role of anti-inflammatory therapy in non-skull-base meningiomas.https://www.mdpi.com/2072-6694/14/17/4285acetylsalicylic acidaspirinmeningiomaproliferationseizure |
| spellingShingle | Johannes Wach Ági Güresir Hartmut Vatter Ulrich Herrlinger Albert Becker Marieta Toma Michael Hölzel Erdem Güresir Low-Dose Acetylsalicylic Acid Treatment in Non-Skull-Base Meningiomas: Impact on Tumor Proliferation and Seizure Burden Cancers acetylsalicylic acid aspirin meningioma proliferation seizure |
| title | Low-Dose Acetylsalicylic Acid Treatment in Non-Skull-Base Meningiomas: Impact on Tumor Proliferation and Seizure Burden |
| title_full | Low-Dose Acetylsalicylic Acid Treatment in Non-Skull-Base Meningiomas: Impact on Tumor Proliferation and Seizure Burden |
| title_fullStr | Low-Dose Acetylsalicylic Acid Treatment in Non-Skull-Base Meningiomas: Impact on Tumor Proliferation and Seizure Burden |
| title_full_unstemmed | Low-Dose Acetylsalicylic Acid Treatment in Non-Skull-Base Meningiomas: Impact on Tumor Proliferation and Seizure Burden |
| title_short | Low-Dose Acetylsalicylic Acid Treatment in Non-Skull-Base Meningiomas: Impact on Tumor Proliferation and Seizure Burden |
| title_sort | low dose acetylsalicylic acid treatment in non skull base meningiomas impact on tumor proliferation and seizure burden |
| topic | acetylsalicylic acid aspirin meningioma proliferation seizure |
| url | https://www.mdpi.com/2072-6694/14/17/4285 |
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