In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics
Directing nanomedicines to desired locations - such as tumour sites - is difficult to achieve selectively. Here, the authors develop a method to covalently crosslink peptide-modified upconversion nanocrystals into tumour sites for photodynamic therapy and show in vivotumour inhibition in mice.
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10432 |
| _version_ | 1818980091492827136 |
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| author | Xiangzhao Ai Chris Jun Hui Ho Junxin Aw Amalina Binte Ebrahim Attia Jing Mu Yu Wang Xiaoyong Wang Yong Wang Xiaogang Liu Huabing Chen Mingyuan Gao Xiaoyuan Chen Edwin K.L. Yeow Gang Liu Malini Olivo Bengang Xing |
| author_facet | Xiangzhao Ai Chris Jun Hui Ho Junxin Aw Amalina Binte Ebrahim Attia Jing Mu Yu Wang Xiaoyong Wang Yong Wang Xiaogang Liu Huabing Chen Mingyuan Gao Xiaoyuan Chen Edwin K.L. Yeow Gang Liu Malini Olivo Bengang Xing |
| author_sort | Xiangzhao Ai |
| collection | DOAJ |
| description | Directing nanomedicines to desired locations - such as tumour sites - is difficult to achieve selectively. Here, the authors develop a method to covalently crosslink peptide-modified upconversion nanocrystals into tumour sites for photodynamic therapy and show in vivotumour inhibition in mice. |
| first_indexed | 2024-12-20T17:09:55Z |
| format | Article |
| id | doaj.art-b434ee5fcfd84c1696406efcde257735 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T17:09:55Z |
| publishDate | 2016-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b434ee5fcfd84c1696406efcde2577352022-12-21T19:32:11ZengNature PortfolioNature Communications2041-17232016-01-01711910.1038/ncomms10432In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranosticsXiangzhao Ai0Chris Jun Hui Ho1Junxin Aw2Amalina Binte Ebrahim Attia3Jing Mu4Yu Wang5Xiaoyong Wang6Yong Wang7Xiaogang Liu8Huabing Chen9Mingyuan Gao10Xiaoyuan Chen11Edwin K.L. Yeow12Gang Liu13Malini Olivo14Bengang Xing15Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological UniversitySingapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR)Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological UniversitySingapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR)Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological UniversityDepartment of Chemistry, National University of SingaporeState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen UniversitySchool of Radiation Medicine and Protection, Soochow UniversityDepartment of Chemistry, National University of SingaporeSchool of Radiation Medicine and Protection, Soochow UniversitySchool of Radiation Medicine and Protection, Soochow UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen UniversityDivision of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological UniversityState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen UniversitySingapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR)Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological UniversityDirecting nanomedicines to desired locations - such as tumour sites - is difficult to achieve selectively. Here, the authors develop a method to covalently crosslink peptide-modified upconversion nanocrystals into tumour sites for photodynamic therapy and show in vivotumour inhibition in mice.https://doi.org/10.1038/ncomms10432 |
| spellingShingle | Xiangzhao Ai Chris Jun Hui Ho Junxin Aw Amalina Binte Ebrahim Attia Jing Mu Yu Wang Xiaoyong Wang Yong Wang Xiaogang Liu Huabing Chen Mingyuan Gao Xiaoyuan Chen Edwin K.L. Yeow Gang Liu Malini Olivo Bengang Xing In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics Nature Communications |
| title | In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics |
| title_full | In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics |
| title_fullStr | In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics |
| title_full_unstemmed | In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics |
| title_short | In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics |
| title_sort | in vivo covalent cross linking of photon converted rare earth nanostructures for tumour localization and theranostics |
| url | https://doi.org/10.1038/ncomms10432 |
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