Potential contribution of early endothelial progenitor cell (eEPC)-to-macrophage switching in the development of pulmonary plexogenic lesion

Potential contribution of early endothelial progenitor cell (eEPC)-to-macrophage switching in the development of pulmonary plexogenic lesion

Abstract Background Plexiform lesions, which have a dynamic appearance in structure and cellular composition, are the histological hallmark of severe pulmonary arterial hypertension in humans. The pathogenesis of the lesion development remains largely unknown, although it may be related to local inf...

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Bibliographic Details
Main Authors: Feng-Jin Shao, Xiao-Ling Guo, Jia-Xue Xu, Rui Liu, Dan-Yue Li, Qing-Hao Li, Ting Zhou, Cun Fang, Xun Tan
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Respiratory Research
Subjects:
Pulmonary arterial hypertension
Pulmonary arterial pressure
Plexiform lesion
Nuclear factor erythroid 2-related factor 2
Endothelial progenitor cells
Phenotypic switching
Online Access:https://doi.org/10.1186/s12931-022-02210-7

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