Long-Term Tetrabromobisphenol A Exposure Induces Gut Microbiota Imbalance and Metabolic Disorders via the Peroxisome Proliferator-Activated Receptor Signaling Pathway in the Regenerated Gut of <i>Apostichopus japonicus</i>
Tetrabromobisphenol A (TBBPA), a commonly utilized brominated flame retardant, is found in many types of abiotic and biotic matrices. TBBPA can increase oxidative stress, disrupt the endocrine system, cause neurodevelopmental disorders and activate peroxisome proliferator-activated receptors to modu...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
|
| Series: | Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-7737/12/11/1365 |
| _version_ | 1827640524111085568 |
|---|---|
| author | Xiaojun Song Ying Lin Yinfeng Zhang Zi Wang Xiaohan Li Jixiang Liu Wenwen Jiang Jianing Chen Linxuan Wu Junjie Rong Kefeng Xu Guodong Wang |
| author_facet | Xiaojun Song Ying Lin Yinfeng Zhang Zi Wang Xiaohan Li Jixiang Liu Wenwen Jiang Jianing Chen Linxuan Wu Junjie Rong Kefeng Xu Guodong Wang |
| author_sort | Xiaojun Song |
| collection | DOAJ |
| description | Tetrabromobisphenol A (TBBPA), a commonly utilized brominated flame retardant, is found in many types of abiotic and biotic matrices. TBBPA can increase oxidative stress, disrupt the endocrine system, cause neurodevelopmental disorders and activate peroxisome proliferator-activated receptors to modulate lipid deposits in aquatic animals. However, the toxic mechanism of TBBPA on the gut microbiota and intestinal health remains unclear. <i>Apostichopus japonicus</i> is an ideal model for studying the relationship between environmental contaminants and intestinal health due to its unique capacity for evisceration and quickly regenerated intestine. In the present study, we investigated the toxic mechanism of TBBPA on the gut microbiota and intestinal health in the regenerated intestine of <i>A. japonicus</i>. The results show that TBBPA exposure decreased the health of the regenerated intestine and the enzymatic activities, alpha diversity indices, and the relative abundance of the gut microbiota. Transcriptome analysis shows that TBBPA exposure affected lipid metabolism via the PPAR signaling pathway during the process of intestinal regeneration in <i>A. japonicus</i>, suggesting that TBBPA exposure can affect the composition and function of the gut microbiota and intestinal health in the regenerated intestine of <i>A. japonicus</i>. These results provide a basis for further research on the potential toxicity of TBBPA to the intestinal health in animals. |
| first_indexed | 2024-03-09T17:00:52Z |
| format | Article |
| id | doaj.art-b436e7bd8e0146769aa869e2239f4e84 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T17:00:52Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-b436e7bd8e0146769aa869e2239f4e842023-11-24T14:30:04ZengMDPI AGBiology2079-77372023-10-011211136510.3390/biology12111365Long-Term Tetrabromobisphenol A Exposure Induces Gut Microbiota Imbalance and Metabolic Disorders via the Peroxisome Proliferator-Activated Receptor Signaling Pathway in the Regenerated Gut of <i>Apostichopus japonicus</i>Xiaojun Song0Ying Lin1Yinfeng Zhang2Zi Wang3Xiaohan Li4Jixiang Liu5Wenwen Jiang6Jianing Chen7Linxuan Wu8Junjie Rong9Kefeng Xu10Guodong Wang11School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao 266109, ChinaSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao 266109, ChinaCollege of Medicine, Qingdao University, Qingdao 266021, ChinaSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao 266109, ChinaSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao 266109, ChinaSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao 266109, ChinaSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao 266109, ChinaSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao 266109, ChinaSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao 266109, ChinaSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao 266109, ChinaMarine Science Research Institute of Shandong Province, National Oceanographic Center, Qingdao 266104, ChinaSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao 266109, ChinaTetrabromobisphenol A (TBBPA), a commonly utilized brominated flame retardant, is found in many types of abiotic and biotic matrices. TBBPA can increase oxidative stress, disrupt the endocrine system, cause neurodevelopmental disorders and activate peroxisome proliferator-activated receptors to modulate lipid deposits in aquatic animals. However, the toxic mechanism of TBBPA on the gut microbiota and intestinal health remains unclear. <i>Apostichopus japonicus</i> is an ideal model for studying the relationship between environmental contaminants and intestinal health due to its unique capacity for evisceration and quickly regenerated intestine. In the present study, we investigated the toxic mechanism of TBBPA on the gut microbiota and intestinal health in the regenerated intestine of <i>A. japonicus</i>. The results show that TBBPA exposure decreased the health of the regenerated intestine and the enzymatic activities, alpha diversity indices, and the relative abundance of the gut microbiota. Transcriptome analysis shows that TBBPA exposure affected lipid metabolism via the PPAR signaling pathway during the process of intestinal regeneration in <i>A. japonicus</i>, suggesting that TBBPA exposure can affect the composition and function of the gut microbiota and intestinal health in the regenerated intestine of <i>A. japonicus</i>. These results provide a basis for further research on the potential toxicity of TBBPA to the intestinal health in animals.https://www.mdpi.com/2079-7737/12/11/1365<i>Apostichopus japonicus</i>TBBPAintestine microbiotalipid metabolismPPAR signaling pathway |
| spellingShingle | Xiaojun Song Ying Lin Yinfeng Zhang Zi Wang Xiaohan Li Jixiang Liu Wenwen Jiang Jianing Chen Linxuan Wu Junjie Rong Kefeng Xu Guodong Wang Long-Term Tetrabromobisphenol A Exposure Induces Gut Microbiota Imbalance and Metabolic Disorders via the Peroxisome Proliferator-Activated Receptor Signaling Pathway in the Regenerated Gut of <i>Apostichopus japonicus</i> Biology <i>Apostichopus japonicus</i> TBBPA intestine microbiota lipid metabolism PPAR signaling pathway |
| title | Long-Term Tetrabromobisphenol A Exposure Induces Gut Microbiota Imbalance and Metabolic Disorders via the Peroxisome Proliferator-Activated Receptor Signaling Pathway in the Regenerated Gut of <i>Apostichopus japonicus</i> |
| title_full | Long-Term Tetrabromobisphenol A Exposure Induces Gut Microbiota Imbalance and Metabolic Disorders via the Peroxisome Proliferator-Activated Receptor Signaling Pathway in the Regenerated Gut of <i>Apostichopus japonicus</i> |
| title_fullStr | Long-Term Tetrabromobisphenol A Exposure Induces Gut Microbiota Imbalance and Metabolic Disorders via the Peroxisome Proliferator-Activated Receptor Signaling Pathway in the Regenerated Gut of <i>Apostichopus japonicus</i> |
| title_full_unstemmed | Long-Term Tetrabromobisphenol A Exposure Induces Gut Microbiota Imbalance and Metabolic Disorders via the Peroxisome Proliferator-Activated Receptor Signaling Pathway in the Regenerated Gut of <i>Apostichopus japonicus</i> |
| title_short | Long-Term Tetrabromobisphenol A Exposure Induces Gut Microbiota Imbalance and Metabolic Disorders via the Peroxisome Proliferator-Activated Receptor Signaling Pathway in the Regenerated Gut of <i>Apostichopus japonicus</i> |
| title_sort | long term tetrabromobisphenol a exposure induces gut microbiota imbalance and metabolic disorders via the peroxisome proliferator activated receptor signaling pathway in the regenerated gut of i apostichopus japonicus i |
| topic | <i>Apostichopus japonicus</i> TBBPA intestine microbiota lipid metabolism PPAR signaling pathway |
| url | https://www.mdpi.com/2079-7737/12/11/1365 |
| work_keys_str_mv | AT xiaojunsong longtermtetrabromobisphenolaexposureinducesgutmicrobiotaimbalanceandmetabolicdisordersviatheperoxisomeproliferatoractivatedreceptorsignalingpathwayintheregeneratedgutofiapostichopusjaponicusi AT yinglin longtermtetrabromobisphenolaexposureinducesgutmicrobiotaimbalanceandmetabolicdisordersviatheperoxisomeproliferatoractivatedreceptorsignalingpathwayintheregeneratedgutofiapostichopusjaponicusi AT yinfengzhang longtermtetrabromobisphenolaexposureinducesgutmicrobiotaimbalanceandmetabolicdisordersviatheperoxisomeproliferatoractivatedreceptorsignalingpathwayintheregeneratedgutofiapostichopusjaponicusi AT ziwang longtermtetrabromobisphenolaexposureinducesgutmicrobiotaimbalanceandmetabolicdisordersviatheperoxisomeproliferatoractivatedreceptorsignalingpathwayintheregeneratedgutofiapostichopusjaponicusi AT xiaohanli longtermtetrabromobisphenolaexposureinducesgutmicrobiotaimbalanceandmetabolicdisordersviatheperoxisomeproliferatoractivatedreceptorsignalingpathwayintheregeneratedgutofiapostichopusjaponicusi AT jixiangliu longtermtetrabromobisphenolaexposureinducesgutmicrobiotaimbalanceandmetabolicdisordersviatheperoxisomeproliferatoractivatedreceptorsignalingpathwayintheregeneratedgutofiapostichopusjaponicusi AT wenwenjiang longtermtetrabromobisphenolaexposureinducesgutmicrobiotaimbalanceandmetabolicdisordersviatheperoxisomeproliferatoractivatedreceptorsignalingpathwayintheregeneratedgutofiapostichopusjaponicusi AT jianingchen longtermtetrabromobisphenolaexposureinducesgutmicrobiotaimbalanceandmetabolicdisordersviatheperoxisomeproliferatoractivatedreceptorsignalingpathwayintheregeneratedgutofiapostichopusjaponicusi AT linxuanwu longtermtetrabromobisphenolaexposureinducesgutmicrobiotaimbalanceandmetabolicdisordersviatheperoxisomeproliferatoractivatedreceptorsignalingpathwayintheregeneratedgutofiapostichopusjaponicusi AT junjierong longtermtetrabromobisphenolaexposureinducesgutmicrobiotaimbalanceandmetabolicdisordersviatheperoxisomeproliferatoractivatedreceptorsignalingpathwayintheregeneratedgutofiapostichopusjaponicusi AT kefengxu longtermtetrabromobisphenolaexposureinducesgutmicrobiotaimbalanceandmetabolicdisordersviatheperoxisomeproliferatoractivatedreceptorsignalingpathwayintheregeneratedgutofiapostichopusjaponicusi AT guodongwang longtermtetrabromobisphenolaexposureinducesgutmicrobiotaimbalanceandmetabolicdisordersviatheperoxisomeproliferatoractivatedreceptorsignalingpathwayintheregeneratedgutofiapostichopusjaponicusi |