N-Acetylcysteine Antagonizes NGF Activation of TrkA through Disulfide Bridge Interaction, an Effect Which May Contribute to Its Analgesic Activity

N-Acetylcysteine Antagonizes NGF Activation of TrkA through Disulfide Bridge Interaction, an Effect Which May Contribute to Its Analgesic Activity

N-acetylcysteine (NAC), a mucolytic agent and an antidote to acetaminophen intoxication, has been studied in experimental conditions and trials exploring its analgesic activity based on its antioxidant and anti-inflammatory properties. The purpose of this study is to investigate additional mechanism...

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Bibliographic Details
Main Authors: Stefano Govoni, Piercarlo Fantucci, Nicoletta Marchesi, Jacopo Vertemara, Alessia Pascale, Massimo Allegri, Laura Calvillo, Emilio Vanoli
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
TrkA
pain
N-acetylcysteine
NGF
Online Access:https://www.mdpi.com/1422-0067/25/1/206

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