Global prevalence of drug-resistant tuberculosis: a systematic review and meta-analysis
Abstract Background Tuberculosis is a bacterial infectious disease, which affects different parts of a human body, mainly lungs and can lead to the patient’s death. The aim of this study is to investigate the global prevalence of drug-resistant tuberculosis using a systematic review and meta-analysi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | Infectious Diseases of Poverty |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40249-023-01107-x |
| _version_ | 1797817726589206528 |
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| author | Nader Salari Amir Hossein Kanjoori Amin Hosseinian-Far Razie Hasheminezhad Kamran Mansouri Masoud Mohammadi |
| author_facet | Nader Salari Amir Hossein Kanjoori Amin Hosseinian-Far Razie Hasheminezhad Kamran Mansouri Masoud Mohammadi |
| author_sort | Nader Salari |
| collection | DOAJ |
| description | Abstract Background Tuberculosis is a bacterial infectious disease, which affects different parts of a human body, mainly lungs and can lead to the patient’s death. The aim of this study is to investigate the global prevalence of drug-resistant tuberculosis using a systematic review and meta-analysis. Methods In this study, the PubMed, Scopus, Web of Science, Embase, ScienceDirect and Google Scholar repositories were systematically searched to find studies reporting the global prevalence of drug-resistant tuberculosis. The search did not entail a lower time limit, and articles published up until August 2022 were considered. Random effects model was used to perform the analysis. The heterogeneity of the studies was examined with the I 2 test. Data analysis was conducted within the Comprehensive Meta-Analysis software. Results In the review of 148 studies with a sample size of 318,430 people, the I 2 index showed high heterogeneity (I 2 = 99.6), and accordingly random effects method was used to analyze the results. Publication bias was also examined using the Begg and Mazumdar correlation test which indicated the existence of publication bias in the studies (P = 0.008). According to our meta-analysis, the global pooled prevalence of multi-drug resistant TB is 11.6% (95% CI: 9.1–14.5%). Conclusions The global prevalence of drug-resistant tuberculosis was found to be very high, thus health authorities should consider ways to control and manage the disease to prevent a wider spread of tuberculosis and potentially subsequent deaths. |
| first_indexed | 2024-03-13T08:57:41Z |
| format | Article |
| id | doaj.art-b43833051598450fab17325daaa7ea99 |
| institution | Directory Open Access Journal |
| issn | 2049-9957 |
| language | English |
| last_indexed | 2024-03-13T08:57:41Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Diseases of Poverty |
| spelling | doaj.art-b43833051598450fab17325daaa7ea992023-05-28T11:31:03ZengBMCInfectious Diseases of Poverty2049-99572023-05-0112111210.1186/s40249-023-01107-xGlobal prevalence of drug-resistant tuberculosis: a systematic review and meta-analysisNader Salari0Amir Hossein Kanjoori1Amin Hosseinian-Far2Razie Hasheminezhad3Kamran Mansouri4Masoud Mohammadi5Department of Biostatistics, School of Health, Kermanshah University of Medical SciencesStudent Research Committee, Kermanshah University of Medical SciencesDepartment of Business Systems & Operations, University of NorthamptonStudent Research Committee, Kermanshah University of Medical SciencesMedical Biology Research Center, Kermanshah University of Medical SciencesCellular and Molecular Research Center, Gerash University of Medical SciencesAbstract Background Tuberculosis is a bacterial infectious disease, which affects different parts of a human body, mainly lungs and can lead to the patient’s death. The aim of this study is to investigate the global prevalence of drug-resistant tuberculosis using a systematic review and meta-analysis. Methods In this study, the PubMed, Scopus, Web of Science, Embase, ScienceDirect and Google Scholar repositories were systematically searched to find studies reporting the global prevalence of drug-resistant tuberculosis. The search did not entail a lower time limit, and articles published up until August 2022 were considered. Random effects model was used to perform the analysis. The heterogeneity of the studies was examined with the I 2 test. Data analysis was conducted within the Comprehensive Meta-Analysis software. Results In the review of 148 studies with a sample size of 318,430 people, the I 2 index showed high heterogeneity (I 2 = 99.6), and accordingly random effects method was used to analyze the results. Publication bias was also examined using the Begg and Mazumdar correlation test which indicated the existence of publication bias in the studies (P = 0.008). According to our meta-analysis, the global pooled prevalence of multi-drug resistant TB is 11.6% (95% CI: 9.1–14.5%). Conclusions The global prevalence of drug-resistant tuberculosis was found to be very high, thus health authorities should consider ways to control and manage the disease to prevent a wider spread of tuberculosis and potentially subsequent deaths.https://doi.org/10.1186/s40249-023-01107-xPrevalenceDrug-resistant tuberculosisBurdenOutbreakTB |
| spellingShingle | Nader Salari Amir Hossein Kanjoori Amin Hosseinian-Far Razie Hasheminezhad Kamran Mansouri Masoud Mohammadi Global prevalence of drug-resistant tuberculosis: a systematic review and meta-analysis Infectious Diseases of Poverty Prevalence Drug-resistant tuberculosis Burden Outbreak TB |
| title | Global prevalence of drug-resistant tuberculosis: a systematic review and meta-analysis |
| title_full | Global prevalence of drug-resistant tuberculosis: a systematic review and meta-analysis |
| title_fullStr | Global prevalence of drug-resistant tuberculosis: a systematic review and meta-analysis |
| title_full_unstemmed | Global prevalence of drug-resistant tuberculosis: a systematic review and meta-analysis |
| title_short | Global prevalence of drug-resistant tuberculosis: a systematic review and meta-analysis |
| title_sort | global prevalence of drug resistant tuberculosis a systematic review and meta analysis |
| topic | Prevalence Drug-resistant tuberculosis Burden Outbreak TB |
| url | https://doi.org/10.1186/s40249-023-01107-x |
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