The diagnostic utility of heparin-binding protein among patients with bacterial infections: a systematic review and meta-analysis
Abstract Background Bacterial infections are considered a leading cause of hospitalization and death globally. There is still a need for a rapid and feasible biomarker for bacterial infections. Heparin-binding protein (HBP) was shown to be related to bacterial infections. The objective of the study...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-024-09004-w |
| _version_ | 1827328466527191040 |
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| author | Amira Mohamed Taha Khaled Abouelmagd Mohamed Mosad Omar Qasi Najah Mohammed Ali Mohammed Tarek Hasan Sahar A. Allam Roua Arian Omar El Sayed Rageh Mohamed Abd-ElGawad |
| author_facet | Amira Mohamed Taha Khaled Abouelmagd Mohamed Mosad Omar Qasi Najah Mohammed Ali Mohammed Tarek Hasan Sahar A. Allam Roua Arian Omar El Sayed Rageh Mohamed Abd-ElGawad |
| author_sort | Amira Mohamed Taha |
| collection | DOAJ |
| description | Abstract Background Bacterial infections are considered a leading cause of hospitalization and death globally. There is still a need for a rapid and feasible biomarker for bacterial infections. Heparin-binding protein (HBP) was shown to be related to bacterial infections. The objective of the study is to investigate the diagnostic accuracy of HBP in bacterial infections. Methods Articles were screened in PubMed, SCOPUS, Web of Science, and Cochrane to recognize eligible studies. We included studies investigating the diagnostic accuracy of HBP and reported the necessary data to construct 2 × 2 tables. A univariate analysis was conducted to determine the pooled sensitivity and specificity, and a bivariate diagnostic random-effects model was used to calculate the optimal cut-off point. Results The analysis comprised sixteen studies in total. Plasma HBP showed a sensitivity of 0.90 (95% CI: [0.79, 0.96]) and a specificity of 0.87 (95% CI: [0.66, 0.96]) in diagnosing bacterial infections using blood samples. Pooling data from seven studies revealed that HBP in cerebrospinal fluid (CSF) has sensitivity and specificity of 96% (95% CI: [0.85, 0.99]), and 95% (95% CI: [0.89, 0.97]), respectively, for the diagnosis of bacterial meningitis. In urinary tract infections (UTI), urine-HBP was revealed to have a high diagnostic value in discriminating bacterial from non-bacterial UTI infection at a cut-off value of 32.868 ng/ml with sensitivity and specificity of 87%. Conclusion HBP has shown a high diagnostic accuracy of bacterial infections, including UTI and meningitis. Further studies are needed to determine its prognostic value and whether it could guide antibiotic therapy. |
| first_indexed | 2024-03-07T15:18:19Z |
| format | Article |
| id | doaj.art-b43844d18c4b4d118e22cbc759eaf909 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-03-07T15:18:19Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-b43844d18c4b4d118e22cbc759eaf9092024-03-05T17:49:56ZengBMCBMC Infectious Diseases1471-23342024-01-0124112010.1186/s12879-024-09004-wThe diagnostic utility of heparin-binding protein among patients with bacterial infections: a systematic review and meta-analysisAmira Mohamed Taha0Khaled Abouelmagd1Mohamed Mosad Omar2Qasi Najah3Mohammed Ali4Mohammed Tarek Hasan5Sahar A. Allam6Roua Arian7Omar El Sayed Rageh8Mohamed Abd-ElGawad9Faculty of Medicine, Fayoum UniversityCardiology Department, Faculty of Medicine, Al-Azhar UniversityKasr Alainy School of Medicine, Cairo UniversityFaculty of Medicine, University of EL-MergibFaculty of Medicine, Al-Azhar UniversityFaculty of Medicine, Al-Azhar UniversityFaculty of Medicine, Tanta UniversityFaculty of Medicine, University of AleppoFaculty of Medicine, Tanta UniversityFaculty of Medicine, Fayoum UniversityAbstract Background Bacterial infections are considered a leading cause of hospitalization and death globally. There is still a need for a rapid and feasible biomarker for bacterial infections. Heparin-binding protein (HBP) was shown to be related to bacterial infections. The objective of the study is to investigate the diagnostic accuracy of HBP in bacterial infections. Methods Articles were screened in PubMed, SCOPUS, Web of Science, and Cochrane to recognize eligible studies. We included studies investigating the diagnostic accuracy of HBP and reported the necessary data to construct 2 × 2 tables. A univariate analysis was conducted to determine the pooled sensitivity and specificity, and a bivariate diagnostic random-effects model was used to calculate the optimal cut-off point. Results The analysis comprised sixteen studies in total. Plasma HBP showed a sensitivity of 0.90 (95% CI: [0.79, 0.96]) and a specificity of 0.87 (95% CI: [0.66, 0.96]) in diagnosing bacterial infections using blood samples. Pooling data from seven studies revealed that HBP in cerebrospinal fluid (CSF) has sensitivity and specificity of 96% (95% CI: [0.85, 0.99]), and 95% (95% CI: [0.89, 0.97]), respectively, for the diagnosis of bacterial meningitis. In urinary tract infections (UTI), urine-HBP was revealed to have a high diagnostic value in discriminating bacterial from non-bacterial UTI infection at a cut-off value of 32.868 ng/ml with sensitivity and specificity of 87%. Conclusion HBP has shown a high diagnostic accuracy of bacterial infections, including UTI and meningitis. Further studies are needed to determine its prognostic value and whether it could guide antibiotic therapy.https://doi.org/10.1186/s12879-024-09004-wHeparin binding proteinBacterial infectionsDiagnostic accuracyBiomarkers |
| spellingShingle | Amira Mohamed Taha Khaled Abouelmagd Mohamed Mosad Omar Qasi Najah Mohammed Ali Mohammed Tarek Hasan Sahar A. Allam Roua Arian Omar El Sayed Rageh Mohamed Abd-ElGawad The diagnostic utility of heparin-binding protein among patients with bacterial infections: a systematic review and meta-analysis BMC Infectious Diseases Heparin binding protein Bacterial infections Diagnostic accuracy Biomarkers |
| title | The diagnostic utility of heparin-binding protein among patients with bacterial infections: a systematic review and meta-analysis |
| title_full | The diagnostic utility of heparin-binding protein among patients with bacterial infections: a systematic review and meta-analysis |
| title_fullStr | The diagnostic utility of heparin-binding protein among patients with bacterial infections: a systematic review and meta-analysis |
| title_full_unstemmed | The diagnostic utility of heparin-binding protein among patients with bacterial infections: a systematic review and meta-analysis |
| title_short | The diagnostic utility of heparin-binding protein among patients with bacterial infections: a systematic review and meta-analysis |
| title_sort | diagnostic utility of heparin binding protein among patients with bacterial infections a systematic review and meta analysis |
| topic | Heparin binding protein Bacterial infections Diagnostic accuracy Biomarkers |
| url | https://doi.org/10.1186/s12879-024-09004-w |
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