Screen-printed sensors for efficient potentiometric analysis of tolperisone hydrochloride in presence of its co-formulated drugs
Abstract Researchers seeking for green chemistry to help safeguard and boost the economy and the environment by discovering unique ways to decrease waste and find substitutes for dangerous chemicals. In this study, a green potentiometric ion-selective electrode (ISE) was developed for measurement of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Chemistry |
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| Online Access: | https://doi.org/10.1186/s13065-022-00883-1 |
| _version_ | 1811225206515040256 |
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| author | Mohamed Rizk Emad M. Hussein Safaa Toubar Emad Ramzy Marwa I. Helmy |
| author_facet | Mohamed Rizk Emad M. Hussein Safaa Toubar Emad Ramzy Marwa I. Helmy |
| author_sort | Mohamed Rizk |
| collection | DOAJ |
| description | Abstract Researchers seeking for green chemistry to help safeguard and boost the economy and the environment by discovering unique ways to decrease waste and find substitutes for dangerous chemicals. In this study, a green potentiometric ion-selective electrode (ISE) was developed for measurement of tolperisone HCl (TOLP) in bulk and Pharmaceutical dosage forms in presence of diclofenac sodium and paracetamol as co-formulated drugs. This paper presents the manufacture and characterization of a disposable potentiometric ion-selective strip with an enhanced detection limit for (TOLP) measurement in its tablet dosage form either alone or in presence of the co-formulated drugs. Numerous ion pairs (IPs), such as TOLP-tetraphenylborate (TOLP-TPB), TOLP-phosphotungstic acid (TOLP-PTA), and TOLP-ammonium Reinecke (TOLP- RKT) are tested in presence of different plasticizers. The optimal potentiometric response with a near Nernstian slope of 55.949 mV/decade was achieved within a linear concentration range of 5 $$\times$$ × 10–5 − 1 $$\times$$ × 10–2 M using (PTA) and ortho nitrophenyl octyl ether (o-NPOE) as a plasticizer. The effect of the nanoparticles on the membrane stability was studied using the graphene nanoplatelets which have an effective role in the enhancement of some constructed sensors stability. Finally, the developed technique is validated for the estimation of TOLP with high accuracy and precision. Graphical Abstract |
| first_indexed | 2024-04-12T09:01:52Z |
| format | Article |
| id | doaj.art-b43a6714326248e381d1a192477a970f |
| institution | Directory Open Access Journal |
| issn | 2661-801X |
| language | English |
| last_indexed | 2024-04-12T09:01:52Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Chemistry |
| spelling | doaj.art-b43a6714326248e381d1a192477a970f2022-12-22T03:39:12ZengBMCBMC Chemistry2661-801X2022-11-0116111010.1186/s13065-022-00883-1Screen-printed sensors for efficient potentiometric analysis of tolperisone hydrochloride in presence of its co-formulated drugsMohamed Rizk0Emad M. Hussein1Safaa Toubar2Emad Ramzy3Marwa I. Helmy4Analytical Chemistry Department, Faculty of Pharmacy, Helwan UniversityNational Organization for Drug Control & Research (NODCAR)Analytical Chemistry Department, Faculty of Pharmacy, Helwan UniversityAnalytical Chemistry Department, Faculty of Pharmacy, Helwan UniversityAnalytical Chemistry Department, Faculty of Pharmacy, Helwan UniversityAbstract Researchers seeking for green chemistry to help safeguard and boost the economy and the environment by discovering unique ways to decrease waste and find substitutes for dangerous chemicals. In this study, a green potentiometric ion-selective electrode (ISE) was developed for measurement of tolperisone HCl (TOLP) in bulk and Pharmaceutical dosage forms in presence of diclofenac sodium and paracetamol as co-formulated drugs. This paper presents the manufacture and characterization of a disposable potentiometric ion-selective strip with an enhanced detection limit for (TOLP) measurement in its tablet dosage form either alone or in presence of the co-formulated drugs. Numerous ion pairs (IPs), such as TOLP-tetraphenylborate (TOLP-TPB), TOLP-phosphotungstic acid (TOLP-PTA), and TOLP-ammonium Reinecke (TOLP- RKT) are tested in presence of different plasticizers. The optimal potentiometric response with a near Nernstian slope of 55.949 mV/decade was achieved within a linear concentration range of 5 $$\times$$ × 10–5 − 1 $$\times$$ × 10–2 M using (PTA) and ortho nitrophenyl octyl ether (o-NPOE) as a plasticizer. The effect of the nanoparticles on the membrane stability was studied using the graphene nanoplatelets which have an effective role in the enhancement of some constructed sensors stability. Finally, the developed technique is validated for the estimation of TOLP with high accuracy and precision. Graphical Abstracthttps://doi.org/10.1186/s13065-022-00883-1Screen printedIon selective electrodeGraphene nano plateletsTolperisone HCLPharmaceutical analysis |
| spellingShingle | Mohamed Rizk Emad M. Hussein Safaa Toubar Emad Ramzy Marwa I. Helmy Screen-printed sensors for efficient potentiometric analysis of tolperisone hydrochloride in presence of its co-formulated drugs BMC Chemistry Screen printed Ion selective electrode Graphene nano platelets Tolperisone HCL Pharmaceutical analysis |
| title | Screen-printed sensors for efficient potentiometric analysis of tolperisone hydrochloride in presence of its co-formulated drugs |
| title_full | Screen-printed sensors for efficient potentiometric analysis of tolperisone hydrochloride in presence of its co-formulated drugs |
| title_fullStr | Screen-printed sensors for efficient potentiometric analysis of tolperisone hydrochloride in presence of its co-formulated drugs |
| title_full_unstemmed | Screen-printed sensors for efficient potentiometric analysis of tolperisone hydrochloride in presence of its co-formulated drugs |
| title_short | Screen-printed sensors for efficient potentiometric analysis of tolperisone hydrochloride in presence of its co-formulated drugs |
| title_sort | screen printed sensors for efficient potentiometric analysis of tolperisone hydrochloride in presence of its co formulated drugs |
| topic | Screen printed Ion selective electrode Graphene nano platelets Tolperisone HCL Pharmaceutical analysis |
| url | https://doi.org/10.1186/s13065-022-00883-1 |
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