LIVER TRANSPLANTATION FROM SEXAGENARIAN AND OLDER
Donor organs shortage leads to extending criteria for deceased liver donation in the whole world.Aim: to compare results of deceased donor liver transplantation (DDLT) depending of donor age over 60 years old.Materials and methods: the study includes 390 DDLT from January 2010 to November 2017. All...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2018-04-01
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| Series: | Vestnik Transplantologii i Iskusstvennyh Organov |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/849 |
| _version_ | 1797872024143527936 |
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| author | S. V. Gautier М. N. Kornilov I. A. Miloserdov M. G. Minina D. N. Kruglov S. I. Zubenko |
| author_facet | S. V. Gautier М. N. Kornilov I. A. Miloserdov M. G. Minina D. N. Kruglov S. I. Zubenko |
| author_sort | S. V. Gautier |
| collection | DOAJ |
| description | Donor organs shortage leads to extending criteria for deceased liver donation in the whole world.Aim: to compare results of deceased donor liver transplantation (DDLT) depending of donor age over 60 years old.Materials and methods: the study includes 390 DDLT from January 2010 to November 2017. All liver donors separated by age for two groups: I – 60 years and older (n = 26); II – younger than 60 years (n = 364). All donors were standardized by demographic, laboratory fi ndings and inotropic drug requirement. Results: no difference between both groups in severity of ischemia-reperfusion injury, ICU or in-hospital staying (median 2 and 7,5 days respectively) was found. There is also no difference between biliary or vascular complication rate. 5-year actuarial survival rate found no difference between both groups (I: 70%: II: 76%, p = 0,54).Conclusion. Using grafts from donors older than 60 years don’t worsen early and late results of DDLT. Care should be taken to avoid other risk factors (cold ischemia time, warm ischemia time). |
| first_indexed | 2024-04-10T00:52:16Z |
| format | Article |
| id | doaj.art-b43c9c8d5f29456aaf6f0c6e448f1877 |
| institution | Directory Open Access Journal |
| issn | 1995-1191 |
| language | Russian |
| last_indexed | 2024-04-10T00:52:16Z |
| publishDate | 2018-04-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Vestnik Transplantologii i Iskusstvennyh Organov |
| spelling | doaj.art-b43c9c8d5f29456aaf6f0c6e448f18772023-03-13T10:37:24ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovVestnik Transplantologii i Iskusstvennyh Organov1995-11912018-04-0120161210.15825/1995-1191-2018-1-6-12678LIVER TRANSPLANTATION FROM SEXAGENARIAN AND OLDERS. V. Gautier0М. N. Kornilov1I. A. Miloserdov2M. G. Minina3D. N. Kruglov4S. I. Zubenko5V.I. Shumakov National Medical Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian Federation; I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovsky University)V.I. Shumakov National Medical Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian FederationV.I. Shumakov National Medical Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian Federation; I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovsky University)Moscow coordinating centre of organ donation, Moscow Department of HealthV.I. Shumakov National Medical Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian FederationV.I. Shumakov National Medical Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian FederationDonor organs shortage leads to extending criteria for deceased liver donation in the whole world.Aim: to compare results of deceased donor liver transplantation (DDLT) depending of donor age over 60 years old.Materials and methods: the study includes 390 DDLT from January 2010 to November 2017. All liver donors separated by age for two groups: I – 60 years and older (n = 26); II – younger than 60 years (n = 364). All donors were standardized by demographic, laboratory fi ndings and inotropic drug requirement. Results: no difference between both groups in severity of ischemia-reperfusion injury, ICU or in-hospital staying (median 2 and 7,5 days respectively) was found. There is also no difference between biliary or vascular complication rate. 5-year actuarial survival rate found no difference between both groups (I: 70%: II: 76%, p = 0,54).Conclusion. Using grafts from donors older than 60 years don’t worsen early and late results of DDLT. Care should be taken to avoid other risk factors (cold ischemia time, warm ischemia time).https://journal.transpl.ru/vtio/article/view/849deceased donor liver transplantationexpanded criteria donorelderly deceased donors |
| spellingShingle | S. V. Gautier М. N. Kornilov I. A. Miloserdov M. G. Minina D. N. Kruglov S. I. Zubenko LIVER TRANSPLANTATION FROM SEXAGENARIAN AND OLDER Vestnik Transplantologii i Iskusstvennyh Organov deceased donor liver transplantation expanded criteria donor elderly deceased donors |
| title | LIVER TRANSPLANTATION FROM SEXAGENARIAN AND OLDER |
| title_full | LIVER TRANSPLANTATION FROM SEXAGENARIAN AND OLDER |
| title_fullStr | LIVER TRANSPLANTATION FROM SEXAGENARIAN AND OLDER |
| title_full_unstemmed | LIVER TRANSPLANTATION FROM SEXAGENARIAN AND OLDER |
| title_short | LIVER TRANSPLANTATION FROM SEXAGENARIAN AND OLDER |
| title_sort | liver transplantation from sexagenarian and older |
| topic | deceased donor liver transplantation expanded criteria donor elderly deceased donors |
| url | https://journal.transpl.ru/vtio/article/view/849 |
| work_keys_str_mv | AT svgautier livertransplantationfromsexagenarianandolder AT mnkornilov livertransplantationfromsexagenarianandolder AT iamiloserdov livertransplantationfromsexagenarianandolder AT mgminina livertransplantationfromsexagenarianandolder AT dnkruglov livertransplantationfromsexagenarianandolder AT sizubenko livertransplantationfromsexagenarianandolder |