IgE-dependent human basophil responses are inversely associated with the sarcoplasmic reticulum Ca2+-ATPase (SERCA)

IgE-dependent human basophil responses are inversely associated with the sarcoplasmic reticulum Ca2+-ATPase (SERCA)

Basophils crucially contribute to allergies and other Th2-driven diseases by rapidly releasing inflammatory and immunomodulatory mediators following high-affinity IgE-receptor crosslinking. Although these basophil-mediated responses depend on sensitization with antigen-specific IgE, this does not ne...

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Bibliographic Details
Main Authors: Anette T. Hansen Selnø, Vadim V. Sumbayev, Bernhard F. Gibbs
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
basophils
SERCA
IgE receptor
histamine
inhibitory signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1052290/full

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