Genetic evidence on the causality between gut microbiota and various asthma phenotypes: a two-sample Mendelian randomization study
IntroductionAsthma is a multifarious disease that manifests in various phenotypes. Among the various factors that contribute to the development of asthma, the gut microbiota has recently emerged as a compelling area of investigation. This study aims to investigate the causal relationships between gu...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-01-01
|
| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1270067/full |
| _version_ | 1797357722178420736 |
|---|---|
| author | Zi-Xuan Cheng Yi-Xing Wu Zhi-Jun Jie Xing-Jing Li Jing Zhang |
| author_facet | Zi-Xuan Cheng Yi-Xing Wu Zhi-Jun Jie Xing-Jing Li Jing Zhang |
| author_sort | Zi-Xuan Cheng |
| collection | DOAJ |
| description | IntroductionAsthma is a multifarious disease that manifests in various phenotypes. Among the various factors that contribute to the development of asthma, the gut microbiota has recently emerged as a compelling area of investigation. This study aims to investigate the causal relationships between gut microbiota and distinct asthma phenotypes.MethodsThe genome-wide association study (GWAS) summary statistics for 211 gut microbial taxa were used as study exposure. Five traits pertaining to various asthma phenotypes (asthma, allergic asthma, childhood asthma, suggestive for eosinophilic asthma and obesity-related asthma) were included as study outcome. We conducted Mendelian randomization (MR) analysis and sensitivity analysis for each bacterial taxa and asthma phenotypes.ResultWe discovered a total of 58 associations that exhibited evidence of causality. Out of these, 4 associations remained significant even after applying multiple correction. An increased risk of asthma was causally associated with higher abundance of genus Holdemanella (OR = 1.11; CI: 1.05-1.17; p = 0.027), genus Oxalobacter (OR = 1.09; CI: 1.04-1.15; p = 0.025) and genus Butyricimonas (OR = 1.14; CI: 1.06-1.22; p = 0.027). Order NB1n was causally linked with an increased risk of obesity-related asthma (OR = 1.17; CI: 1.07-1.29; p = 0.015). There was limited overlap among the taxa that exhibited potential causal relationships with distinct asthma phenotypes.ConclusionOur research has provided genetic evidence that establishes multiple causal relationships between the gut microbiota and distinct asthma phenotypes, supporting the role of the gut microbiota in various asthma phenotypes. It is possible that different taxa play a role in the development of distinct asthma phenotypes. The causal relationships identified in this study require further investigation. |
| first_indexed | 2024-03-08T14:48:15Z |
| format | Article |
| id | doaj.art-b43e0ea675674682ad4afcaa9fb76b1c |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-08T14:48:15Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-b43e0ea675674682ad4afcaa9fb76b1c2024-01-11T05:17:15ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882024-01-011310.3389/fcimb.2023.12700671270067Genetic evidence on the causality between gut microbiota and various asthma phenotypes: a two-sample Mendelian randomization studyZi-Xuan Cheng0Yi-Xing Wu1Zhi-Jun Jie2Xing-Jing Li3Jing Zhang4Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Respiratory and Critical Care Medicine, the Fifth People’s Hospital of Shanghai, Fudan University, Shanghai, ChinaDepartment of Respiratory Medicine, Zhongshan Hospital Wusong Branch, Fudan University, Shanghai, ChinaDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaIntroductionAsthma is a multifarious disease that manifests in various phenotypes. Among the various factors that contribute to the development of asthma, the gut microbiota has recently emerged as a compelling area of investigation. This study aims to investigate the causal relationships between gut microbiota and distinct asthma phenotypes.MethodsThe genome-wide association study (GWAS) summary statistics for 211 gut microbial taxa were used as study exposure. Five traits pertaining to various asthma phenotypes (asthma, allergic asthma, childhood asthma, suggestive for eosinophilic asthma and obesity-related asthma) were included as study outcome. We conducted Mendelian randomization (MR) analysis and sensitivity analysis for each bacterial taxa and asthma phenotypes.ResultWe discovered a total of 58 associations that exhibited evidence of causality. Out of these, 4 associations remained significant even after applying multiple correction. An increased risk of asthma was causally associated with higher abundance of genus Holdemanella (OR = 1.11; CI: 1.05-1.17; p = 0.027), genus Oxalobacter (OR = 1.09; CI: 1.04-1.15; p = 0.025) and genus Butyricimonas (OR = 1.14; CI: 1.06-1.22; p = 0.027). Order NB1n was causally linked with an increased risk of obesity-related asthma (OR = 1.17; CI: 1.07-1.29; p = 0.015). There was limited overlap among the taxa that exhibited potential causal relationships with distinct asthma phenotypes.ConclusionOur research has provided genetic evidence that establishes multiple causal relationships between the gut microbiota and distinct asthma phenotypes, supporting the role of the gut microbiota in various asthma phenotypes. It is possible that different taxa play a role in the development of distinct asthma phenotypes. The causal relationships identified in this study require further investigation.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1270067/fullasthmagut-lung axisgut microbiotaMendelian randomization analysisphenotypesendotypes |
| spellingShingle | Zi-Xuan Cheng Yi-Xing Wu Zhi-Jun Jie Xing-Jing Li Jing Zhang Genetic evidence on the causality between gut microbiota and various asthma phenotypes: a two-sample Mendelian randomization study Frontiers in Cellular and Infection Microbiology asthma gut-lung axis gut microbiota Mendelian randomization analysis phenotypes endotypes |
| title | Genetic evidence on the causality between gut microbiota and various asthma phenotypes: a two-sample Mendelian randomization study |
| title_full | Genetic evidence on the causality between gut microbiota and various asthma phenotypes: a two-sample Mendelian randomization study |
| title_fullStr | Genetic evidence on the causality between gut microbiota and various asthma phenotypes: a two-sample Mendelian randomization study |
| title_full_unstemmed | Genetic evidence on the causality between gut microbiota and various asthma phenotypes: a two-sample Mendelian randomization study |
| title_short | Genetic evidence on the causality between gut microbiota and various asthma phenotypes: a two-sample Mendelian randomization study |
| title_sort | genetic evidence on the causality between gut microbiota and various asthma phenotypes a two sample mendelian randomization study |
| topic | asthma gut-lung axis gut microbiota Mendelian randomization analysis phenotypes endotypes |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1270067/full |
| work_keys_str_mv | AT zixuancheng geneticevidenceonthecausalitybetweengutmicrobiotaandvariousasthmaphenotypesatwosamplemendelianrandomizationstudy AT yixingwu geneticevidenceonthecausalitybetweengutmicrobiotaandvariousasthmaphenotypesatwosamplemendelianrandomizationstudy AT zhijunjie geneticevidenceonthecausalitybetweengutmicrobiotaandvariousasthmaphenotypesatwosamplemendelianrandomizationstudy AT xingjingli geneticevidenceonthecausalitybetweengutmicrobiotaandvariousasthmaphenotypesatwosamplemendelianrandomizationstudy AT jingzhang geneticevidenceonthecausalitybetweengutmicrobiotaandvariousasthmaphenotypesatwosamplemendelianrandomizationstudy |