Exercise mediates ubiquitin signalling in human skeletal muscle
Abstract Physical activity or regular exercise provides many beneficial effects towards human health, helping prevent and ameliorate metabolic diseases. However, certain molecular mechanisms that mediate these health benefits remain poorly understood. Parker et al. provided the first global analysis...
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| Format: | Article |
| Language: | English |
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Wiley
2022-06-01
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| Series: | FASEB BioAdvances |
| Subjects: | |
| Online Access: | https://doi.org/10.1096/fba.2021-00142 |
| _version_ | 1818233134516273152 |
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| author | Samuel O. Lord Yu‐Chiang Lai |
| author_facet | Samuel O. Lord Yu‐Chiang Lai |
| author_sort | Samuel O. Lord |
| collection | DOAJ |
| description | Abstract Physical activity or regular exercise provides many beneficial effects towards human health, helping prevent and ameliorate metabolic diseases. However, certain molecular mechanisms that mediate these health benefits remain poorly understood. Parker et al. provided the first global analysis of exercise‐regulated ubiquitin signalling in human skeletal muscle, revealing post‐translational modification cross‐talk. As a result of their analysis, NEDDylation is thought to promote ubiquitin signalling for the removal of damaged proteins following exercise. The proteomic dataset generated from their study is invaluable for researchers in this field to validate new mechanistic hypotheses. To further reveal molecular mechanisms regulated by exercise, future research could employ more sensitive mass spectrometry‐based workflows that increase the detection of both ubiquitylated sites and peptides and subsequently identify more exercise‐regulated ubiquitin signalling pathways. |
| first_indexed | 2024-12-12T11:17:21Z |
| format | Article |
| id | doaj.art-b43e2bfa45234d82ae9e73d1f0779bea |
| institution | Directory Open Access Journal |
| issn | 2573-9832 |
| language | English |
| last_indexed | 2024-12-12T11:17:21Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | FASEB BioAdvances |
| spelling | doaj.art-b43e2bfa45234d82ae9e73d1f0779bea2022-12-22T00:26:08ZengWileyFASEB BioAdvances2573-98322022-06-014640240710.1096/fba.2021-00142Exercise mediates ubiquitin signalling in human skeletal muscleSamuel O. Lord0Yu‐Chiang Lai1School of Sport, Exercise and Rehabilitation Sciences University of Birmingham Birmingham UKSchool of Sport, Exercise and Rehabilitation Sciences University of Birmingham Birmingham UKAbstract Physical activity or regular exercise provides many beneficial effects towards human health, helping prevent and ameliorate metabolic diseases. However, certain molecular mechanisms that mediate these health benefits remain poorly understood. Parker et al. provided the first global analysis of exercise‐regulated ubiquitin signalling in human skeletal muscle, revealing post‐translational modification cross‐talk. As a result of their analysis, NEDDylation is thought to promote ubiquitin signalling for the removal of damaged proteins following exercise. The proteomic dataset generated from their study is invaluable for researchers in this field to validate new mechanistic hypotheses. To further reveal molecular mechanisms regulated by exercise, future research could employ more sensitive mass spectrometry‐based workflows that increase the detection of both ubiquitylated sites and peptides and subsequently identify more exercise‐regulated ubiquitin signalling pathways.https://doi.org/10.1096/fba.2021-00142mass spectrometryNEDDylationphysical activityubiquitylationubiquitylome |
| spellingShingle | Samuel O. Lord Yu‐Chiang Lai Exercise mediates ubiquitin signalling in human skeletal muscle FASEB BioAdvances mass spectrometry NEDDylation physical activity ubiquitylation ubiquitylome |
| title | Exercise mediates ubiquitin signalling in human skeletal muscle |
| title_full | Exercise mediates ubiquitin signalling in human skeletal muscle |
| title_fullStr | Exercise mediates ubiquitin signalling in human skeletal muscle |
| title_full_unstemmed | Exercise mediates ubiquitin signalling in human skeletal muscle |
| title_short | Exercise mediates ubiquitin signalling in human skeletal muscle |
| title_sort | exercise mediates ubiquitin signalling in human skeletal muscle |
| topic | mass spectrometry NEDDylation physical activity ubiquitylation ubiquitylome |
| url | https://doi.org/10.1096/fba.2021-00142 |
| work_keys_str_mv | AT samuelolord exercisemediatesubiquitinsignallinginhumanskeletalmuscle AT yuchianglai exercisemediatesubiquitinsignallinginhumanskeletalmuscle |