Misfolded protein aggregation and altered cellular pathways in neurodegenerative diseases
Neurodegenerative diseases are estimated by the World Health Organization to be the second leading cause of human death by 2050. They actually are a group of chronic neurological disorders leading to motor, cognitive and sensory impairments in both human and nonhuman species. Despite different in cl...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Innovation Publishing House Pte. Ltd.
2020-09-01
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| Series: | STEMedicine |
| Subjects: | |
| Online Access: | https://stemedicine.org/index.php/stem/article/view/63 |
| _version_ | 1818580507806400512 |
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| author | Huifang Li Zhenghong Yu Wei Zhang |
| author_facet | Huifang Li Zhenghong Yu Wei Zhang |
| author_sort | Huifang Li |
| collection | DOAJ |
| description | Neurodegenerative diseases are estimated by the World Health Organization to be the second leading cause of human death by 2050. They actually are a group of chronic neurological disorders leading to motor, cognitive and sensory impairments in both human and nonhuman species. Despite different in clinical manifestation, prevalence, risk factors, cell types injured and genes hijacked, neurodegenerative disorders are usually associated with the misfolding and aggregation of a distinct protein that accumulates in diverse cellular locations including the nucleus, cytoplasm, plasma membrane and extracellular space. Here we intend to give an overview of the characters and features of several pathogenic protein aggregates in disease brains, and introduce some general signaling pathways involved in protein homeostasis with emphasis on their puzzling roles under the degenerative conditions. |
| first_indexed | 2024-12-16T07:18:42Z |
| format | Article |
| id | doaj.art-b43e8f0932ec4a289449db4405f0ab0b |
| institution | Directory Open Access Journal |
| issn | 2705-1188 |
| language | English |
| last_indexed | 2024-12-16T07:18:42Z |
| publishDate | 2020-09-01 |
| publisher | Innovation Publishing House Pte. Ltd. |
| record_format | Article |
| series | STEMedicine |
| spelling | doaj.art-b43e8f0932ec4a289449db4405f0ab0b2022-12-21T22:39:42ZengInnovation Publishing House Pte. Ltd.STEMedicine2705-11882020-09-011410.37175/stemedicine.v1i4.63Misfolded protein aggregation and altered cellular pathways in neurodegenerative diseasesHuifang Li0Zhenghong Yu1Wei Zhang2College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China. National Experimental Teaching Demonstration Center of Animal Science, Nanjing Agricultural University, Nanjing 210095, China. Department of Rheumatology and Immunology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China. National Experimental Teaching Demonstration Center of Animal Science, Nanjing Agricultural University, Nanjing 210095, China.Neurodegenerative diseases are estimated by the World Health Organization to be the second leading cause of human death by 2050. They actually are a group of chronic neurological disorders leading to motor, cognitive and sensory impairments in both human and nonhuman species. Despite different in clinical manifestation, prevalence, risk factors, cell types injured and genes hijacked, neurodegenerative disorders are usually associated with the misfolding and aggregation of a distinct protein that accumulates in diverse cellular locations including the nucleus, cytoplasm, plasma membrane and extracellular space. Here we intend to give an overview of the characters and features of several pathogenic protein aggregates in disease brains, and introduce some general signaling pathways involved in protein homeostasis with emphasis on their puzzling roles under the degenerative conditions.https://stemedicine.org/index.php/stem/article/view/63Neurodegenerative diseases, misfolded protein aggregates, Unfolded protein response, Protein clearance pathways, Insulin/IGF/TOR |
| spellingShingle | Huifang Li Zhenghong Yu Wei Zhang Misfolded protein aggregation and altered cellular pathways in neurodegenerative diseases STEMedicine Neurodegenerative diseases, misfolded protein aggregates, Unfolded protein response, Protein clearance pathways, Insulin/IGF/TOR |
| title | Misfolded protein aggregation and altered cellular pathways in neurodegenerative diseases |
| title_full | Misfolded protein aggregation and altered cellular pathways in neurodegenerative diseases |
| title_fullStr | Misfolded protein aggregation and altered cellular pathways in neurodegenerative diseases |
| title_full_unstemmed | Misfolded protein aggregation and altered cellular pathways in neurodegenerative diseases |
| title_short | Misfolded protein aggregation and altered cellular pathways in neurodegenerative diseases |
| title_sort | misfolded protein aggregation and altered cellular pathways in neurodegenerative diseases |
| topic | Neurodegenerative diseases, misfolded protein aggregates, Unfolded protein response, Protein clearance pathways, Insulin/IGF/TOR |
| url | https://stemedicine.org/index.php/stem/article/view/63 |
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