De-isolation of vaccinated COVID-19 health care workers using rapid antigen detection test
Background: COVID-19 de-isolation guidelines of health care workers (HCW) were formulated based on evidence describing the duration of infectious viral shedding of the wild SARS-CoV-2 virus. During the periods of COVID-19 vaccination and variants, a test-based approach was recommended to end isolati...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Journal of Infection and Public Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034122001782 |
| _version_ | 1818501633628176384 |
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| author | Abeer N. Alshukairi Awad Al-Omari Mohammad K. Al Hroub Jaffar A. Al-Tawfiq Mohammed Qutub Samaher Shaikh Khalid Allali Mohammed F. Saeedi Roaa S. Alosaimi Elaf Alamoudi Lama K. Hefni Aiman El-Saed Fatma S. Alhamlan Ashraf Dada Ghassan Y. Wali |
| author_facet | Abeer N. Alshukairi Awad Al-Omari Mohammad K. Al Hroub Jaffar A. Al-Tawfiq Mohammed Qutub Samaher Shaikh Khalid Allali Mohammed F. Saeedi Roaa S. Alosaimi Elaf Alamoudi Lama K. Hefni Aiman El-Saed Fatma S. Alhamlan Ashraf Dada Ghassan Y. Wali |
| author_sort | Abeer N. Alshukairi |
| collection | DOAJ |
| description | Background: COVID-19 de-isolation guidelines of health care workers (HCW) were formulated based on evidence describing the duration of infectious viral shedding of the wild SARS-CoV-2 virus. During the periods of COVID-19 vaccination and variants, a test-based approach was recommended to end isolation of HCW, based on emerging data describing the viral kinetics of COVID-19 variants. While Rapid antigen detection tests (RADT) are increasingly used in the diagnosis of COVID-19, their use is limited in de-isolation. Methods: We described the use of RADT in the de-isolation of COVID-19 vaccinated HCW with mild infection who were asymptomatic on day 7 post diagnosis in a single center retrospective cohort study during the Omicron surge. Results: Of the 480 HCWs, 173 (36%) had positive RADT. The positivity rate of RADT was not different in HCW who received two doses versus three doses of vaccine (34.4% versus 40.3%, p = 0.239). Conclusions: A symptom based, test-based approach using RADT is a useful tool in the de-isolation of HCW, with mild disease, in the era of Omicron. Further studies are required to evaluate the role of RADT in de-isolation of patients with severe COVID-19 disease. |
| first_indexed | 2024-12-10T20:58:58Z |
| format | Article |
| id | doaj.art-b43eb4d8ca2f4d35b444a36eeb73054f |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-12-10T20:58:58Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-b43eb4d8ca2f4d35b444a36eeb73054f2022-12-22T01:33:53ZengElsevierJournal of Infection and Public Health1876-03412022-08-01158902905De-isolation of vaccinated COVID-19 health care workers using rapid antigen detection testAbeer N. Alshukairi0Awad Al-Omari1Mohammad K. Al Hroub2Jaffar A. Al-Tawfiq3Mohammed Qutub4Samaher Shaikh5Khalid Allali6Mohammed F. Saeedi7Roaa S. Alosaimi8Elaf Alamoudi9Lama K. Hefni10Aiman El-Saed11Fatma S. Alhamlan12Ashraf Dada13Ghassan Y. Wali14Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Kingdom of Saudi Arabia; College of Medicine, AlFaisal University, Riyadh, Kingdom of Saudi Arabia; Correspondence to: Adult Infectious Diseases Section, Department of Medicine King Faisal Specialist Hospital and Research Center, Jeddah PO BOX 40047, Jeddah 21499, Kingdom of Saudi ArabiaCollege of Medicine, AlFaisal University, Riyadh, Kingdom of Saudi Arabia; Department of Critical Care, Dr Sulaiman Al Habib Medical Group, Riyadh, Kingdom of Saudi ArabiaDepartment of Infection Control and Hospital Epidemiology, King Faisal Specialist Hospital and Research Center, Jeddah, Kingdom of Saudi ArabiaInfectious Disease Unit, Specialty Internal Medicine, Johns Hopkins Aramco Healthcare, Dhahran, Kingdom of Saudi Arabia; Infectious Disease Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA; Infectious Disease Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USADepartment of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Kingdom of Saudi ArabiaDepartment of Infection Control and Hospital Epidemiology, King Faisal Specialist Hospital and Research Center, Jeddah, Kingdom of Saudi ArabiaDepartment of Infection Control and Hospital Epidemiology, King Faisal Specialist Hospital and Research Center, Jeddah, Kingdom of Saudi ArabiaDepartment of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Kingdom of Saudi ArabiaDepartment of Medicine, East Jeddah Hospital, Jeddah, Kingdom of Saudi ArabiaDepartment of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Kingdom of Saudi ArabiaDepartment of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Kingdom of Saudi ArabiaDepartment of Infection Prevention and Control, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi ArabiaDepartment of Infection and Immunity, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi ArabiaCollege of Medicine, AlFaisal University, Riyadh, Kingdom of Saudi Arabia; Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Kingdom of Saudi ArabiaDepartment of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Kingdom of Saudi ArabiaBackground: COVID-19 de-isolation guidelines of health care workers (HCW) were formulated based on evidence describing the duration of infectious viral shedding of the wild SARS-CoV-2 virus. During the periods of COVID-19 vaccination and variants, a test-based approach was recommended to end isolation of HCW, based on emerging data describing the viral kinetics of COVID-19 variants. While Rapid antigen detection tests (RADT) are increasingly used in the diagnosis of COVID-19, their use is limited in de-isolation. Methods: We described the use of RADT in the de-isolation of COVID-19 vaccinated HCW with mild infection who were asymptomatic on day 7 post diagnosis in a single center retrospective cohort study during the Omicron surge. Results: Of the 480 HCWs, 173 (36%) had positive RADT. The positivity rate of RADT was not different in HCW who received two doses versus three doses of vaccine (34.4% versus 40.3%, p = 0.239). Conclusions: A symptom based, test-based approach using RADT is a useful tool in the de-isolation of HCW, with mild disease, in the era of Omicron. Further studies are required to evaluate the role of RADT in de-isolation of patients with severe COVID-19 disease.http://www.sciencedirect.com/science/article/pii/S1876034122001782Rapid Antigen testCOVID-19De-isolationHealth care workers |
| spellingShingle | Abeer N. Alshukairi Awad Al-Omari Mohammad K. Al Hroub Jaffar A. Al-Tawfiq Mohammed Qutub Samaher Shaikh Khalid Allali Mohammed F. Saeedi Roaa S. Alosaimi Elaf Alamoudi Lama K. Hefni Aiman El-Saed Fatma S. Alhamlan Ashraf Dada Ghassan Y. Wali De-isolation of vaccinated COVID-19 health care workers using rapid antigen detection test Journal of Infection and Public Health Rapid Antigen test COVID-19 De-isolation Health care workers |
| title | De-isolation of vaccinated COVID-19 health care workers using rapid antigen detection test |
| title_full | De-isolation of vaccinated COVID-19 health care workers using rapid antigen detection test |
| title_fullStr | De-isolation of vaccinated COVID-19 health care workers using rapid antigen detection test |
| title_full_unstemmed | De-isolation of vaccinated COVID-19 health care workers using rapid antigen detection test |
| title_short | De-isolation of vaccinated COVID-19 health care workers using rapid antigen detection test |
| title_sort | de isolation of vaccinated covid 19 health care workers using rapid antigen detection test |
| topic | Rapid Antigen test COVID-19 De-isolation Health care workers |
| url | http://www.sciencedirect.com/science/article/pii/S1876034122001782 |
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