Loss of Heterozygosity in the Tumor DNA of De Novo Diagnosed Patients Is Associated with Poor Outcome for B-ALL but Not for T-ALL

Loss of Heterozygosity in the Tumor DNA of De Novo Diagnosed Patients Is Associated with Poor Outcome for B-ALL but Not for T-ALL

Despite the introduction of new technologies in molecular diagnostics, one should not underestimate the traditional routine methods for studying tumor DNA. Here we present the evidence that short tandem repeat (STR) profiling of tumor DNA relative to DNA from healthy cells might identify chromosomal...

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Bibliographic Details
Main Authors: Natalya Risinskaya, Yana Kozhevnikova, Olga Gavrilina, Julia Chabaeva, Ekaterina Kotova, Anna Yushkova, Galina Isinova, Ksenija Zarubina, Tatiana Obukhova, Sergey Kulikov, Hunan Julhakyan, Andrey Sudarikov, Elena Parovichnikova
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Genes
Subjects:
short tandem repeat (STR)
acute lymphoblastic leukemia
loss of heterozygosity (LOH)
uniparental disomy (UPD)
chromosomal microarray (CMA)
Online Access:https://www.mdpi.com/2073-4425/13/3/398

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