A method to predict edge strands in beta-sheets from protein sequences
There is a need for rules allowing three-dimensional structure information to be derived from protein sequences. In this work, consideration of an elementary protein folding step allows protein sub-sequences which optimize folding to be derived for any given protein sequence. Classical mechanics app...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2013-05-01
|
| Series: | Computational and Structural Biotechnology Journal |
| Subjects: | |
| Online Access: | http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201305001 |
| _version_ | 1818481142753394688 |
|---|---|
| author | Antonin Guilloux Bernard Caudron Jean-Luc Jestin |
| author_facet | Antonin Guilloux Bernard Caudron Jean-Luc Jestin |
| author_sort | Antonin Guilloux |
| collection | DOAJ |
| description | There is a need for rules allowing three-dimensional structure information to be derived from protein sequences. In this work, consideration of an elementary protein folding step allows protein sub-sequences which optimize folding to be derived for any given protein sequence. Classical mechanics applied to this system and the energy conservation law during the elementary folding step yields an equation whose solutions are taken over the field of rational numbers. This formalism is applied to beta-sheets containing two edge strands and at least two central strands. The number of protein sub-sequences optimized for folding per amino acid in beta-strands is shown in particular to predict edge strands from protein sequences. Topological information on beta-strands and loops connecting them is derived for protein sequences with a prediction accuracy of 75%. The statistical significance of the finding is given. Applications in protein structure prediction are envisioned such as for the quality assessment of protein structure models. |
| first_indexed | 2024-12-10T11:31:02Z |
| format | Article |
| id | doaj.art-b4407ef5f32a456db26d66e9529609be |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-12-10T11:31:02Z |
| publishDate | 2013-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-b4407ef5f32a456db26d66e9529609be2022-12-22T01:50:36ZengElsevierComputational and Structural Biotechnology Journal2001-03702013-05-0179e201305001A method to predict edge strands in beta-sheets from protein sequencesAntonin GuillouxBernard CaudronJean-Luc JestinThere is a need for rules allowing three-dimensional structure information to be derived from protein sequences. In this work, consideration of an elementary protein folding step allows protein sub-sequences which optimize folding to be derived for any given protein sequence. Classical mechanics applied to this system and the energy conservation law during the elementary folding step yields an equation whose solutions are taken over the field of rational numbers. This formalism is applied to beta-sheets containing two edge strands and at least two central strands. The number of protein sub-sequences optimized for folding per amino acid in beta-strands is shown in particular to predict edge strands from protein sequences. Topological information on beta-strands and loops connecting them is derived for protein sequences with a prediction accuracy of 75%. The statistical significance of the finding is given. Applications in protein structure prediction are envisioned such as for the quality assessment of protein structure models.http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201305001Protein structurestructure predictiontopologybeta-strandscentral strandloopturn |
| spellingShingle | Antonin Guilloux Bernard Caudron Jean-Luc Jestin A method to predict edge strands in beta-sheets from protein sequences Computational and Structural Biotechnology Journal Protein structure structure prediction topology beta-strands central strand loop turn |
| title | A method to predict edge strands in beta-sheets from protein sequences |
| title_full | A method to predict edge strands in beta-sheets from protein sequences |
| title_fullStr | A method to predict edge strands in beta-sheets from protein sequences |
| title_full_unstemmed | A method to predict edge strands in beta-sheets from protein sequences |
| title_short | A method to predict edge strands in beta-sheets from protein sequences |
| title_sort | method to predict edge strands in beta sheets from protein sequences |
| topic | Protein structure structure prediction topology beta-strands central strand loop turn |
| url | http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201305001 |
| work_keys_str_mv | AT antoninguilloux amethodtopredictedgestrandsinbetasheetsfromproteinsequences AT bernardcaudron amethodtopredictedgestrandsinbetasheetsfromproteinsequences AT jeanlucjestin amethodtopredictedgestrandsinbetasheetsfromproteinsequences AT antoninguilloux methodtopredictedgestrandsinbetasheetsfromproteinsequences AT bernardcaudron methodtopredictedgestrandsinbetasheetsfromproteinsequences AT jeanlucjestin methodtopredictedgestrandsinbetasheetsfromproteinsequences |