Quantitative omics analyses of NCOA4 deficiency reveal an integral role of ferritinophagy in iron homeostasis of hippocampal neuronal HT22 cells

Quantitative omics analyses of NCOA4 deficiency reveal an integral role of ferritinophagy in iron homeostasis of hippocampal neuronal HT22 cells

IntroductionNeurons require iron to support their metabolism, growth, and differentiation, but are also susceptible to iron-induced oxidative stress and cytotoxicity. Ferritin, a cytosolic iron storage unit, mediates cellular adaptation to fluctuations in iron delivery. NCOA4 has been characterized...

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Bibliographic Details
Main Authors: Emily F. Bengson, Cole A. Guggisberg, Thomas W. Bastian, Michael K. Georgieff, Moon-Suhn Ryu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Nutrition
Subjects:
ferritinophagy
proteomics
RNA-seq
ferritin
iron deficiency
IRP2
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2023.1054852/full

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