Epidemiology of antibiotic consumption and resistance in Mauritius
IntroductionThis study aims at determining the pattern of antibiotic consumption and resistance in Mauritius, a tropical island in the Indian Ocean.MethodologyAntibiotic consumption was measured in kilograms of purchased antibiotics and also in defined daily dose (DDD) in different health institutio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Antibiotics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/frabi.2024.1222580/full |
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| author | Lovena Preeyadarshini Veerapa-Mangroo Lovena Preeyadarshini Veerapa-Mangroo Harena Rasamoelina-Andriamanivo Harena Rasamoelina-Andriamanivo Mohammad Iqbal Issack Mohammad Iqbal Issack Eric Cardinale Eric Cardinale |
| author_facet | Lovena Preeyadarshini Veerapa-Mangroo Lovena Preeyadarshini Veerapa-Mangroo Harena Rasamoelina-Andriamanivo Harena Rasamoelina-Andriamanivo Mohammad Iqbal Issack Mohammad Iqbal Issack Eric Cardinale Eric Cardinale |
| author_sort | Lovena Preeyadarshini Veerapa-Mangroo |
| collection | DOAJ |
| description | IntroductionThis study aims at determining the pattern of antibiotic consumption and resistance in Mauritius, a tropical island in the Indian Ocean.MethodologyAntibiotic consumption was measured in kilograms of purchased antibiotics and also in defined daily dose (DDD) in different health institutions from 2015 to 2017. Data on antibiotic resistance was collected at the Central Health Laboratory (CHL) at Victoria Hospital and at Jeetoo Hospital Laboratory, where antibiotic sensitivity testing is done for all public health institutions. For this study, Escherichia coli, Klebsiella species, Acinetobacter species, and Pseudomonas aeruginosa isolates from blood samples of patients from 2015 to 2023 were included. The resistance rate and prevalence of multi-drug-resistant (MDR) organisms were calculated.ResultsThe amount of antibiotics (in kilograms) distributed to the human sector was between 11,000 to 13,000 kg, compared to only 700 to 1,500 kg in the animal sector. The DDD per 1,000 inhabitants per day was 20.9, 22.1, and 21.7 in 2015, 2016, and 2017, respectively, with a greater consumption of WATCH and RESERVE group antibiotics in the private sector. In public health institutions, health centers in the northern region had the highest DDD per 1,000 outpatients per day for beta-lactams penicillins and quinolones. Concerning antibiotic resistance, the proportion of MDR Acinetobacter baumannii and Pseudomonas aeruginosa has increased from 58% to 74% and from 33% to 45%, respectively, from 2015 to 2023. During the same period, the proportion of E. coli and K. pneumoniae isolates sensitive to ceftriaxone decreased from 55% to 39% and from 37% to 22%, respectively, while the proportion of E. coli, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa isolates sensitive to meropenem decreased from 98% to 94%, 83% to 53%, 45% to 28%, and 63% to 47%, respectively.ConclusionThis study provides valuable insights on antibiotic consumption and resistance in the country and emphasizes the significance of adopting a One Health approach to combat antimicrobial resistance (AMR) effectively. These findings will aid policymakers in formulating targeted strategies to address the challenge of AMR and should be integrated into the National Action Plan on AMR in Mauritius. |
| first_indexed | 2024-04-24T08:51:20Z |
| format | Article |
| id | doaj.art-b4421074d399484ebb3afba8b61a73b1 |
| institution | Directory Open Access Journal |
| issn | 2813-2467 |
| language | English |
| last_indexed | 2024-04-24T08:51:20Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Antibiotics |
| spelling | doaj.art-b4421074d399484ebb3afba8b61a73b12024-04-16T11:05:12ZengFrontiers Media S.A.Frontiers in Antibiotics2813-24672024-04-01310.3389/frabi.2024.12225801222580Epidemiology of antibiotic consumption and resistance in MauritiusLovena Preeyadarshini Veerapa-Mangroo0Lovena Preeyadarshini Veerapa-Mangroo1Harena Rasamoelina-Andriamanivo2Harena Rasamoelina-Andriamanivo3Mohammad Iqbal Issack4Mohammad Iqbal Issack5Eric Cardinale6Eric Cardinale7Surveillance Epidemiologique et Gestion des Alertes (SEGA) One Health network, Indian Ocean Commission, Ebene, MauritiusEpidemic Intelligence Unit, Indian Ocean Commission, Ebene, MauritiusSurveillance Epidemiologique et Gestion des Alertes (SEGA) One Health network, Indian Ocean Commission, Ebene, MauritiusEpidemic Intelligence Unit, Indian Ocean Commission, Ebene, MauritiusSurveillance Epidemiologique et Gestion des Alertes (SEGA) One Health network, Indian Ocean Commission, Ebene, MauritiusCentral Health Laboratory, Victoria Hospital, Quatre Bornes, MauritiusSurveillance Epidemiologique et Gestion des Alertes (SEGA) One Health network, Indian Ocean Commission, Ebene, MauritiusUnité mixte de recherche (UMR) Animal, Santé, Territoires, Risques, Écosystèmes (ASTRE) — Centre de coopération internationale en recherche agronomique pour le développement (CIRAD), Montpellier, FranceIntroductionThis study aims at determining the pattern of antibiotic consumption and resistance in Mauritius, a tropical island in the Indian Ocean.MethodologyAntibiotic consumption was measured in kilograms of purchased antibiotics and also in defined daily dose (DDD) in different health institutions from 2015 to 2017. Data on antibiotic resistance was collected at the Central Health Laboratory (CHL) at Victoria Hospital and at Jeetoo Hospital Laboratory, where antibiotic sensitivity testing is done for all public health institutions. For this study, Escherichia coli, Klebsiella species, Acinetobacter species, and Pseudomonas aeruginosa isolates from blood samples of patients from 2015 to 2023 were included. The resistance rate and prevalence of multi-drug-resistant (MDR) organisms were calculated.ResultsThe amount of antibiotics (in kilograms) distributed to the human sector was between 11,000 to 13,000 kg, compared to only 700 to 1,500 kg in the animal sector. The DDD per 1,000 inhabitants per day was 20.9, 22.1, and 21.7 in 2015, 2016, and 2017, respectively, with a greater consumption of WATCH and RESERVE group antibiotics in the private sector. In public health institutions, health centers in the northern region had the highest DDD per 1,000 outpatients per day for beta-lactams penicillins and quinolones. Concerning antibiotic resistance, the proportion of MDR Acinetobacter baumannii and Pseudomonas aeruginosa has increased from 58% to 74% and from 33% to 45%, respectively, from 2015 to 2023. During the same period, the proportion of E. coli and K. pneumoniae isolates sensitive to ceftriaxone decreased from 55% to 39% and from 37% to 22%, respectively, while the proportion of E. coli, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa isolates sensitive to meropenem decreased from 98% to 94%, 83% to 53%, 45% to 28%, and 63% to 47%, respectively.ConclusionThis study provides valuable insights on antibiotic consumption and resistance in the country and emphasizes the significance of adopting a One Health approach to combat antimicrobial resistance (AMR) effectively. These findings will aid policymakers in formulating targeted strategies to address the challenge of AMR and should be integrated into the National Action Plan on AMR in Mauritius.https://www.frontiersin.org/articles/10.3389/frabi.2024.1222580/fullantibiotic consumptionhuman and animal sectorantibiotic resistancemulti-drug resistant organismsMauritiustropical island |
| spellingShingle | Lovena Preeyadarshini Veerapa-Mangroo Lovena Preeyadarshini Veerapa-Mangroo Harena Rasamoelina-Andriamanivo Harena Rasamoelina-Andriamanivo Mohammad Iqbal Issack Mohammad Iqbal Issack Eric Cardinale Eric Cardinale Epidemiology of antibiotic consumption and resistance in Mauritius Frontiers in Antibiotics antibiotic consumption human and animal sector antibiotic resistance multi-drug resistant organisms Mauritius tropical island |
| title | Epidemiology of antibiotic consumption and resistance in Mauritius |
| title_full | Epidemiology of antibiotic consumption and resistance in Mauritius |
| title_fullStr | Epidemiology of antibiotic consumption and resistance in Mauritius |
| title_full_unstemmed | Epidemiology of antibiotic consumption and resistance in Mauritius |
| title_short | Epidemiology of antibiotic consumption and resistance in Mauritius |
| title_sort | epidemiology of antibiotic consumption and resistance in mauritius |
| topic | antibiotic consumption human and animal sector antibiotic resistance multi-drug resistant organisms Mauritius tropical island |
| url | https://www.frontiersin.org/articles/10.3389/frabi.2024.1222580/full |
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