Fingolimod ameliorates chronic experimental autoimmune neuritis by modulating inflammatory cytokines and Akt/mTOR/NF‐κB signaling

Fingolimod ameliorates chronic experimental autoimmune neuritis by modulating inflammatory cytokines and Akt/mTOR/NF‐κB signaling

Abstract Objective Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune‐mediated disease that targets the myelin sheaths of the peripheral nerves. Fingolimod is a sphingosine 1 phosphate (S1P) receptor antagonist with a high affinity for S1P receptors through the Akt–mTOR pa...

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Bibliographic Details
Main Authors: Yuan Feng, Fang Feng, Shuyi Pan, Jiewen Zhang, Wei Li
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Brain and Behavior
Subjects:
chronic experimental autoimmune neuritis
chronic inflammatory demyelinating polyradiculoneuropathy
fingolimod
NF‐κB
peripheral neuropathy
Online Access:https://doi.org/10.1002/brb3.2965

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