Outbreak of carbapenem-resistant Klebsiella pneumoniae: two-year epidemiologic follow-up in a tertiary hospital
This study describes a carbapenem-resistant Klebsiella pneumoniae (CRKP) outbreak that occurred from October 2008-December 2010. Polymerase chain reaction assays were performed to detect the blaKPC gene and molecular typing was performed using pulsed-field gel electrophoresis (PFGE). There were 33 C...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2013-02-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000100019 |
| _version_ | 1827844870035734528 |
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| author | Graziella Hanna Pereira Doroti O Garcia Marcelo Mostardeiro Karina SVN Fanti Anna S Levin |
| author_facet | Graziella Hanna Pereira Doroti O Garcia Marcelo Mostardeiro Karina SVN Fanti Anna S Levin |
| author_sort | Graziella Hanna Pereira |
| collection | DOAJ |
| description | This study describes a carbapenem-resistant Klebsiella pneumoniae (CRKP) outbreak that occurred from October 2008-December 2010. Polymerase chain reaction assays were performed to detect the blaKPC gene and molecular typing was performed using pulsed-field gel electrophoresis (PFGE). There were 33 CRKP infections; PFGE revealed five genotypes: genotype A in five (15%), B in 18 (55%), C in eight (24%) and two unique profiles. Genotype B was disseminated in all hospital units and belonged to the same clone identified in 11 different hospitals in the state of São Paulo. Sixteen (48%) patients died. Seven isolates (21%) were resistant to polymyxin B and 45% were resistant to tigecycline and amikacin. |
| first_indexed | 2024-03-12T08:49:05Z |
| format | Article |
| id | doaj.art-b4442d047ccb482bbbcdfb9ae146ce6f |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:49:05Z |
| publishDate | 2013-02-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-b4442d047ccb482bbbcdfb9ae146ce6f2023-09-02T16:22:40ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602013-02-011081113115Outbreak of carbapenem-resistant Klebsiella pneumoniae: two-year epidemiologic follow-up in a tertiary hospitalGraziella Hanna PereiraDoroti O GarciaMarcelo MostardeiroKarina SVN FantiAnna S LevinThis study describes a carbapenem-resistant Klebsiella pneumoniae (CRKP) outbreak that occurred from October 2008-December 2010. Polymerase chain reaction assays were performed to detect the blaKPC gene and molecular typing was performed using pulsed-field gel electrophoresis (PFGE). There were 33 CRKP infections; PFGE revealed five genotypes: genotype A in five (15%), B in 18 (55%), C in eight (24%) and two unique profiles. Genotype B was disseminated in all hospital units and belonged to the same clone identified in 11 different hospitals in the state of São Paulo. Sixteen (48%) patients died. Seven isolates (21%) were resistant to polymyxin B and 45% were resistant to tigecycline and amikacin.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000100019carbapenem-resistant K. pneumoniaenosocomial outbreakpolymyxin resistance |
| spellingShingle | Graziella Hanna Pereira Doroti O Garcia Marcelo Mostardeiro Karina SVN Fanti Anna S Levin Outbreak of carbapenem-resistant Klebsiella pneumoniae: two-year epidemiologic follow-up in a tertiary hospital Memorias do Instituto Oswaldo Cruz carbapenem-resistant K. pneumoniae nosocomial outbreak polymyxin resistance |
| title | Outbreak of carbapenem-resistant Klebsiella pneumoniae: two-year epidemiologic follow-up in a tertiary hospital |
| title_full | Outbreak of carbapenem-resistant Klebsiella pneumoniae: two-year epidemiologic follow-up in a tertiary hospital |
| title_fullStr | Outbreak of carbapenem-resistant Klebsiella pneumoniae: two-year epidemiologic follow-up in a tertiary hospital |
| title_full_unstemmed | Outbreak of carbapenem-resistant Klebsiella pneumoniae: two-year epidemiologic follow-up in a tertiary hospital |
| title_short | Outbreak of carbapenem-resistant Klebsiella pneumoniae: two-year epidemiologic follow-up in a tertiary hospital |
| title_sort | outbreak of carbapenem resistant klebsiella pneumoniae two year epidemiologic follow up in a tertiary hospital |
| topic | carbapenem-resistant K. pneumoniae nosocomial outbreak polymyxin resistance |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000100019 |
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