PRKACA: the catalytic subunit of protein kinase A and adrenocortical tumors

PRKACA: the catalytic subunit of protein kinase A and adrenocortical tumors

Cyclic-AMP (cAMP)-dependent protein kinase (PKA) is the main effector of cAMP signaling in all tissues. Inactivating mutations of the PRKAR1A gene, coding for the type 1A regulatory subunit of PKA, are responsible for Carney complex and primary pigmented nodular adrenocortical disease (PPNAD). PRKAR...

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Bibliographic Details
Main Authors: Annabel Sophie Berthon, Eva eSzarek, Constantine eStratakis
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Adenoma
Adrenal Cortex
Cushing Syndrome
PKA
PRKACA
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00026/full

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