Delta opioid receptors in Nav1.8 expressing peripheral neurons partially regulate the effect of delta agonist in models of migraine and opioid-induced hyperalgesia

Delta opioid receptors in Nav1.8 expressing peripheral neurons partially regulate the effect of delta agonist in models of migraine and opioid-induced hyperalgesia

Migraine is one of the most common pain disorders and causes disability in millions of people every year. Delta opioid receptors (DOR) have been identified as a novel therapeutic target for migraine and other headache disorders. DORs are present in both peripheral and central regions and it is uncle...

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Bibliographic Details
Main Authors: Zachariah Bertels, Isaac J. Dripps, Pal Shah, Laura S. Moye, Alycia F. Tipton, Kendra Siegersma, Amynah A. Pradhan
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Neurobiology of Pain
Subjects:
Allodynia
Headache disorders
Mouse
Cortical spreading depression
Online Access:http://www.sciencedirect.com/science/article/pii/S2452073X22000162

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