Soluble FMS-Like Tyrosine Kinase-1: Role in placenta accreta spectrum disorder [version 4; peer review: 2 approved]
Background: Placenta accreta is a pregnancy condition where the placenta's blood vessels attach too deeply to the uterine wall. Incidence of placenta accreta is increasingly seen today as the rate of cesarean section increases, however, the exact pathophysiology of this condition is still not...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2022-09-01
|
| Series: | F1000Research |
| Subjects: | |
| Online Access: | https://f1000research.com/articles/10-618/v4 |
| _version_ | 1811195562032103424 |
|---|---|
| author | Bancin Berry Eka Parda Sarma Lumbanraja M Rizki Yaznil Andre M Siahaan |
| author_facet | Bancin Berry Eka Parda Sarma Lumbanraja M Rizki Yaznil Andre M Siahaan |
| author_sort | Bancin Berry Eka Parda |
| collection | DOAJ |
| description | Background: Placenta accreta is a pregnancy condition where the placenta's blood vessels attach too deeply to the uterine wall. Incidence of placenta accreta is increasingly seen today as the rate of cesarean section increases, however, the exact pathophysiology of this condition is still not fully understood. Soluble fms-like tyrosine kinase-1 (sflt-1) as a protein produced by the placenta was found to be decreased in placenta accreta, Therefore we aim to see if sfltsFlt-1 has a role in the development of placenta accreta. Methods: This study involved 40 samples from patients that had been diagnosed with placenta accreta spectrum disorder (case group), and 40 samples from patients with normal pregnancies (control group) at Rumah Skit Umum Pusat H.Adam Malik (RSUP) Haji Adam Malik Medan, in Indonesia. Diagnosis of placenta accreta syndrome was based on Placenta Accreta Spectrum Score (PAS), and International Federation of Gynecology and Obstetrics (FIGO) classification of placenta accreta spectrum disorder.Analyses were performed by independent t-test, man Mann-Whitney U test, and Kruskal-Wallis analysis test, with a P-value <0.05 considered as statistically significant (95%CI). Results: Based on this study, we found that the sFlt-1 level in the case group was lower than the control group. Data analysis using the Kruskal-Wallis test showed that there was a difference in sFlt-1 levels in this study group (p = 0.02), which was further evaluated with post hoc analysis using Mann. -Whitney U test. The results indicated that there were significant differences between the control and PAS 0, PAS1, and PAS 2 (p = 0.043; p = 0.002; p = 0.03). Conclusion: sFlt-1 levels decreased in placental invasive pregnancies compared to normal pregnancies, however, this still needs to be investigated further in a multi-center study, considering that sFlt-1 levels are also influenced by ethnicity and other conditions that cannot be excluded in this study. |
| first_indexed | 2024-04-12T00:45:13Z |
| format | Article |
| id | doaj.art-b4473239a7d343eb9d77c66fe1889f08 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-04-12T00:45:13Z |
| publishDate | 2022-09-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-b4473239a7d343eb9d77c66fe1889f082022-12-22T03:54:53ZengF1000 Research LtdF1000Research2046-14022022-09-0110138138Soluble FMS-Like Tyrosine Kinase-1: Role in placenta accreta spectrum disorder [version 4; peer review: 2 approved]Bancin Berry Eka Parda0https://orcid.org/0000-0002-3147-9857Sarma Lumbanraja1https://orcid.org/0000-0001-9760-4713M Rizki Yaznil2Andre M Siahaan3Resident in Obstetrics and Gynecology Department, Universitas Sumatera Utara, Medan, Sumatera Utara, 20136, IndonesiaFetomaternal Division, Obstetrics and Gynecology Department, Universitas Sumatera Utara, Medan, Sumatera Utara, 20136, IndonesiaFetomaternal Division, Obstetrics and Gynecology Department, Universitas Sumatera Utara, Medan, Sumatera Utara, 20136, IndonesiaNeurosurgery Department, Universitas Sumatera Utara, Medan, Sumatera Utara, 20136, IndonesiaBackground: Placenta accreta is a pregnancy condition where the placenta's blood vessels attach too deeply to the uterine wall. Incidence of placenta accreta is increasingly seen today as the rate of cesarean section increases, however, the exact pathophysiology of this condition is still not fully understood. Soluble fms-like tyrosine kinase-1 (sflt-1) as a protein produced by the placenta was found to be decreased in placenta accreta, Therefore we aim to see if sfltsFlt-1 has a role in the development of placenta accreta. Methods: This study involved 40 samples from patients that had been diagnosed with placenta accreta spectrum disorder (case group), and 40 samples from patients with normal pregnancies (control group) at Rumah Skit Umum Pusat H.Adam Malik (RSUP) Haji Adam Malik Medan, in Indonesia. Diagnosis of placenta accreta syndrome was based on Placenta Accreta Spectrum Score (PAS), and International Federation of Gynecology and Obstetrics (FIGO) classification of placenta accreta spectrum disorder.Analyses were performed by independent t-test, man Mann-Whitney U test, and Kruskal-Wallis analysis test, with a P-value <0.05 considered as statistically significant (95%CI). Results: Based on this study, we found that the sFlt-1 level in the case group was lower than the control group. Data analysis using the Kruskal-Wallis test showed that there was a difference in sFlt-1 levels in this study group (p = 0.02), which was further evaluated with post hoc analysis using Mann. -Whitney U test. The results indicated that there were significant differences between the control and PAS 0, PAS1, and PAS 2 (p = 0.043; p = 0.002; p = 0.03). Conclusion: sFlt-1 levels decreased in placental invasive pregnancies compared to normal pregnancies, however, this still needs to be investigated further in a multi-center study, considering that sFlt-1 levels are also influenced by ethnicity and other conditions that cannot be excluded in this study.https://f1000research.com/articles/10-618/v4Placenta Accreta Pregnancy FIGO PAS Score sflt-1eng |
| spellingShingle | Bancin Berry Eka Parda Sarma Lumbanraja M Rizki Yaznil Andre M Siahaan Soluble FMS-Like Tyrosine Kinase-1: Role in placenta accreta spectrum disorder [version 4; peer review: 2 approved] F1000Research Placenta Accreta Pregnancy FIGO PAS Score sflt-1 eng |
| title | Soluble FMS-Like Tyrosine Kinase-1: Role in placenta accreta spectrum disorder [version 4; peer review: 2 approved] |
| title_full | Soluble FMS-Like Tyrosine Kinase-1: Role in placenta accreta spectrum disorder [version 4; peer review: 2 approved] |
| title_fullStr | Soluble FMS-Like Tyrosine Kinase-1: Role in placenta accreta spectrum disorder [version 4; peer review: 2 approved] |
| title_full_unstemmed | Soluble FMS-Like Tyrosine Kinase-1: Role in placenta accreta spectrum disorder [version 4; peer review: 2 approved] |
| title_short | Soluble FMS-Like Tyrosine Kinase-1: Role in placenta accreta spectrum disorder [version 4; peer review: 2 approved] |
| title_sort | soluble fms like tyrosine kinase 1 role in placenta accreta spectrum disorder version 4 peer review 2 approved |
| topic | Placenta Accreta Pregnancy FIGO PAS Score sflt-1 eng |
| url | https://f1000research.com/articles/10-618/v4 |
| work_keys_str_mv | AT bancinberryekaparda solublefmsliketyrosinekinase1roleinplacentaaccretaspectrumdisorderversion4peerreview2approved AT sarmalumbanraja solublefmsliketyrosinekinase1roleinplacentaaccretaspectrumdisorderversion4peerreview2approved AT mrizkiyaznil solublefmsliketyrosinekinase1roleinplacentaaccretaspectrumdisorderversion4peerreview2approved AT andremsiahaan solublefmsliketyrosinekinase1roleinplacentaaccretaspectrumdisorderversion4peerreview2approved |