KYMASIN UP Natural Product Inhibits Osteoclastogenesis and Improves Osteoblast Activity by Modulating Src and p38 MAPK

KYMASIN UP Natural Product Inhibits Osteoclastogenesis and Improves Osteoblast Activity by Modulating Src and p38 MAPK

The imbalance in osteoblast (OB)-dependent bone formation in favor of osteoclast (OC)-dependent bone resorption is the main cause of loss of tissue mineral mass during bone remodeling leading to osteoporosis conditions. Thus, the suppression of OC activity together with the improvement in the OB act...

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Bibliographic Details
Main Authors: Laura Salvadori, Maria Laura Belladonna, Beatrice Castiglioni, Martina Paiella, Eleonora Panfili, Tommaso Manenti, Catia Ercolani, Luca Cornioli, Sara Chiappalupi, Giulia Gentili, Massimiliano Leigheb, Guglielmo Sorci, Michela Bosetti, Nicoletta Filigheddu, Francesca Riuzzi
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Nutrients
Subjects:
osteoclast
RANKL
osteoblast
signaling pathways
natural product
age-related diseases
Online Access:https://www.mdpi.com/2072-6643/14/15/3053

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