Relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation
Insulin resistance is a phenomenon which accompanies the ongoing metabolic adaptation in cows during early lactation. The aim of our study was to determine the linear correlations of HOMA (Homeostatic Model Assessment), QUICKI (Quantitative Insulin Sensitivity Check Index) and RQUICKI (Revised Quant...
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| Format: | Article |
| Language: | English |
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Sciendo
2017-03-01
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| Series: | Acta Veterinaria |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/acve-2017-0006 |
| _version_ | 1818742097672404992 |
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| author | Cincović Marko Kirovski Danijela Vujanac Ivan Belić Branislava Djoković Radojica |
| author_facet | Cincović Marko Kirovski Danijela Vujanac Ivan Belić Branislava Djoković Radojica |
| author_sort | Cincović Marko |
| collection | DOAJ |
| description | Insulin resistance is a phenomenon which accompanies the ongoing metabolic adaptation in cows during early lactation. The aim of our study was to determine the linear correlations of HOMA (Homeostatic Model Assessment), QUICKI (Quantitative Insulin Sensitivity Check Index) and RQUICKI (Revised Quantitative Insulin Sensitivity Check Index) indexes of insulin resistance with the metabolic status of cows (concentration of hormones, metabolites and body condition score). The experiment included 40 Holstein-Frisian cows in the first week after calving. Indexes of insulin resistance valued: 18.68±5.43 (HOMA), 0.39±0.06 (QUICKI) and 0.45±0.06 (RQUICKI). Linear correlations were examined by testing the coefficient of correlation (r), determination (r2,%) and regression parameter beta (b) in linear equation. A negative correlation was found between HOMA and IGF-I (insulin growth factor I) (r=−0.51, r2=25.0, b=−1.1257, p<0.01). HOMA showed a positive correlation with BHB (betahidroxybutyrate) (r=0.48, r2=23.2, b=0.0234, p<0.01). A positive correlation was found between QUICKI and IGF-I (r=0.30, r2=10.0 b=46.7900, p<0.05) and cholesterol (r=0.44, r2=18.3, b=1.9021, p<0.01). In contrast, QUICKI and BHB (r=0.51, r2=27.1, b=−1.7241, p<0.01), just like QUICKI and BCS (r=0.46, r2=20.9, b=−2.424, p<0.01), showed a negative correlation. RQUICKI showed positive correlations with IGF-I (r=0.48, r2=22.8, b=28.1230, p<0.01), T4 (r=0.47, r2=22.1, b=87.142, p<0.01) and triglycerides (r=0.36, r2=13, b=0.0407, p<0.05) but negative correlations with cortisol (r=−0.36, r2=13.0, b=−9.0332, p<0.05), STH (somatotropic hormone) (r=−0.42, r2=17.3, b=−5.4976, p<0.01), BHB (r=−0.62, r2=38.3, b=−1.1872, p<0.01), total bilirubin (r=−0.58, r2=33.7, b=−7.131, p<0.01) and BCS (body condition score) (r=−0.6, r2=36.4, b=−1.8347, p<0.01). In conclusion, indexes of insulin resistance may be used to evaluate the metabolic status of cows in early lactation. RQUICKI might be the most appropriate predictor of metabolic status due to its linear relationship with most of the parameters included in homeorhetic process. |
| first_indexed | 2024-12-18T02:07:06Z |
| format | Article |
| id | doaj.art-b44794b8d83b41499ff51e3c398f5d9a |
| institution | Directory Open Access Journal |
| issn | 1820-7448 |
| language | English |
| last_indexed | 2024-12-18T02:07:06Z |
| publishDate | 2017-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Veterinaria |
| spelling | doaj.art-b44794b8d83b41499ff51e3c398f5d9a2022-12-21T21:24:34ZengSciendoActa Veterinaria1820-74482017-03-01671577010.1515/acve-2017-0006Relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactationCincović Marko0Kirovski Danijela1Vujanac Ivan2Belić Branislava3Djoković Radojica4Faculty of Agriculture, Department of Veterinary Medicine, University of Novi Sad, Trg D.Obradovića 8, 21000 Novi Sad, SerbiaFaculty of Veterinary Medicine, University of Belgrade, Bulevar Oslobođenja 18, 11000 BeogradFaculty of Veterinary Medicine, University of Belgrade, Bulevar Oslobođenja 18, 11000 BeogradFaculty of Agriculture, Department of Veterinary Medicine, University of Novi Sad, Trg D.Obradovića 8, 21000 Novi Sad, SerbiaFaculty of Agronomy, Department of Animal Science, University of Kragujevac, Ul.Cara Dušana 34, 32000 Čačak, SerbiaInsulin resistance is a phenomenon which accompanies the ongoing metabolic adaptation in cows during early lactation. The aim of our study was to determine the linear correlations of HOMA (Homeostatic Model Assessment), QUICKI (Quantitative Insulin Sensitivity Check Index) and RQUICKI (Revised Quantitative Insulin Sensitivity Check Index) indexes of insulin resistance with the metabolic status of cows (concentration of hormones, metabolites and body condition score). The experiment included 40 Holstein-Frisian cows in the first week after calving. Indexes of insulin resistance valued: 18.68±5.43 (HOMA), 0.39±0.06 (QUICKI) and 0.45±0.06 (RQUICKI). Linear correlations were examined by testing the coefficient of correlation (r), determination (r2,%) and regression parameter beta (b) in linear equation. A negative correlation was found between HOMA and IGF-I (insulin growth factor I) (r=−0.51, r2=25.0, b=−1.1257, p<0.01). HOMA showed a positive correlation with BHB (betahidroxybutyrate) (r=0.48, r2=23.2, b=0.0234, p<0.01). A positive correlation was found between QUICKI and IGF-I (r=0.30, r2=10.0 b=46.7900, p<0.05) and cholesterol (r=0.44, r2=18.3, b=1.9021, p<0.01). In contrast, QUICKI and BHB (r=0.51, r2=27.1, b=−1.7241, p<0.01), just like QUICKI and BCS (r=0.46, r2=20.9, b=−2.424, p<0.01), showed a negative correlation. RQUICKI showed positive correlations with IGF-I (r=0.48, r2=22.8, b=28.1230, p<0.01), T4 (r=0.47, r2=22.1, b=87.142, p<0.01) and triglycerides (r=0.36, r2=13, b=0.0407, p<0.05) but negative correlations with cortisol (r=−0.36, r2=13.0, b=−9.0332, p<0.05), STH (somatotropic hormone) (r=−0.42, r2=17.3, b=−5.4976, p<0.01), BHB (r=−0.62, r2=38.3, b=−1.1872, p<0.01), total bilirubin (r=−0.58, r2=33.7, b=−7.131, p<0.01) and BCS (body condition score) (r=−0.6, r2=36.4, b=−1.8347, p<0.01). In conclusion, indexes of insulin resistance may be used to evaluate the metabolic status of cows in early lactation. RQUICKI might be the most appropriate predictor of metabolic status due to its linear relationship with most of the parameters included in homeorhetic process.https://doi.org/10.1515/acve-2017-0006cowsinsulin resistancemetabolic statusearly lactation |
| spellingShingle | Cincović Marko Kirovski Danijela Vujanac Ivan Belić Branislava Djoković Radojica Relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation Acta Veterinaria cows insulin resistance metabolic status early lactation |
| title | Relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation |
| title_full | Relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation |
| title_fullStr | Relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation |
| title_full_unstemmed | Relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation |
| title_short | Relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation |
| title_sort | relationship between the indexes of insulin resistance and metabolic status in dairy cows during early lactation |
| topic | cows insulin resistance metabolic status early lactation |
| url | https://doi.org/10.1515/acve-2017-0006 |
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