ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers
Genotoxic agents have been shown to activate the Wnt/β-catenin signaling but the underlying mechanism remains unclear. Here, the authors show that upon DNA damage, the deubiquitinase OTULIN activates Wnt/β-catenin signaling by inhibiting linear ubiquitination, K48-linked polyubiquitination, and prot...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-08-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17770-9 |
| _version_ | 1818421100480036864 |
|---|---|
| author | Wei Wang Mingqi Li Suriyan Ponnusamy Yayun Chi Jingyan Xue Beshoy Fahmy Meiyun Fan Gustavo A. Miranda-Carboni Ramesh Narayanan Jiong Wu Zhao-Hui Wu |
| author_facet | Wei Wang Mingqi Li Suriyan Ponnusamy Yayun Chi Jingyan Xue Beshoy Fahmy Meiyun Fan Gustavo A. Miranda-Carboni Ramesh Narayanan Jiong Wu Zhao-Hui Wu |
| author_sort | Wei Wang |
| collection | DOAJ |
| description | Genotoxic agents have been shown to activate the Wnt/β-catenin signaling but the underlying mechanism remains unclear. Here, the authors show that upon DNA damage, the deubiquitinase OTULIN activates Wnt/β-catenin signaling by inhibiting linear ubiquitination, K48-linked polyubiquitination, and proteasomal degradation of β-catenin. |
| first_indexed | 2024-12-14T13:04:59Z |
| format | Article |
| id | doaj.art-b4496d310ec64236a21571f5bea2d9bf |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:04:59Z |
| publishDate | 2020-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b4496d310ec64236a21571f5bea2d9bf2022-12-21T23:00:21ZengNature PortfolioNature Communications2041-17232020-08-0111111510.1038/s41467-020-17770-9ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancersWei Wang0Mingqi Li1Suriyan Ponnusamy2Yayun Chi3Jingyan Xue4Beshoy Fahmy5Meiyun Fan6Gustavo A. Miranda-Carboni7Ramesh Narayanan8Jiong Wu9Zhao-Hui Wu10Department of Radiation Oncology, College of Medicine, University of Tennessee Health Science CenterDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Tennessee Health Science CenterCenter for Cancer Research, University of Tennessee Health Science CenterDepartment of Oncology, Fudan University Shanghai Cancer CenterDepartment of Oncology, Fudan University Shanghai Cancer CenterCenter for Cancer Research, University of Tennessee Health Science CenterDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Tennessee Health Science CenterCenter for Cancer Research, University of Tennessee Health Science CenterCenter for Cancer Research, University of Tennessee Health Science CenterDepartment of Oncology, Fudan University Shanghai Cancer CenterDepartment of Radiation Oncology, College of Medicine, University of Tennessee Health Science CenterGenotoxic agents have been shown to activate the Wnt/β-catenin signaling but the underlying mechanism remains unclear. Here, the authors show that upon DNA damage, the deubiquitinase OTULIN activates Wnt/β-catenin signaling by inhibiting linear ubiquitination, K48-linked polyubiquitination, and proteasomal degradation of β-catenin.https://doi.org/10.1038/s41467-020-17770-9 |
| spellingShingle | Wei Wang Mingqi Li Suriyan Ponnusamy Yayun Chi Jingyan Xue Beshoy Fahmy Meiyun Fan Gustavo A. Miranda-Carboni Ramesh Narayanan Jiong Wu Zhao-Hui Wu ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers Nature Communications |
| title | ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers |
| title_full | ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers |
| title_fullStr | ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers |
| title_full_unstemmed | ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers |
| title_short | ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers |
| title_sort | abl1 dependent otulin phosphorylation promotes genotoxic wnt β catenin activation to enhance drug resistance in breast cancers |
| url | https://doi.org/10.1038/s41467-020-17770-9 |
| work_keys_str_mv | AT weiwang abl1dependentotulinphosphorylationpromotesgenotoxicwntbcateninactivationtoenhancedrugresistanceinbreastcancers AT mingqili abl1dependentotulinphosphorylationpromotesgenotoxicwntbcateninactivationtoenhancedrugresistanceinbreastcancers AT suriyanponnusamy abl1dependentotulinphosphorylationpromotesgenotoxicwntbcateninactivationtoenhancedrugresistanceinbreastcancers AT yayunchi abl1dependentotulinphosphorylationpromotesgenotoxicwntbcateninactivationtoenhancedrugresistanceinbreastcancers AT jingyanxue abl1dependentotulinphosphorylationpromotesgenotoxicwntbcateninactivationtoenhancedrugresistanceinbreastcancers AT beshoyfahmy abl1dependentotulinphosphorylationpromotesgenotoxicwntbcateninactivationtoenhancedrugresistanceinbreastcancers AT meiyunfan abl1dependentotulinphosphorylationpromotesgenotoxicwntbcateninactivationtoenhancedrugresistanceinbreastcancers AT gustavoamirandacarboni abl1dependentotulinphosphorylationpromotesgenotoxicwntbcateninactivationtoenhancedrugresistanceinbreastcancers AT rameshnarayanan abl1dependentotulinphosphorylationpromotesgenotoxicwntbcateninactivationtoenhancedrugresistanceinbreastcancers AT jiongwu abl1dependentotulinphosphorylationpromotesgenotoxicwntbcateninactivationtoenhancedrugresistanceinbreastcancers AT zhaohuiwu abl1dependentotulinphosphorylationpromotesgenotoxicwntbcateninactivationtoenhancedrugresistanceinbreastcancers |