Impact of the implementation of new guidelines on the management of patients with HIV infection at an advanced HIV clinic in Kinshasa, Democratic Republic of Congo (DRC)
Abstract Background HIV continues to be the main determinant morbidity with high mortality rates in Sub-Saharan Africa, with a high number of patients being late presenters with advanced HIV. Clinical management of advanced HIV patients is thus complex and requires strict adherence to updated, empir...
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-020-05470-0 |
| _version_ | 1819115587010297856 |
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| author | F. Mangana L. D. Massaquoi R. Moudachirou R. Harrison T. Kaluangila G. Mucinya N. Ntabugi G. Van Cutsem R. Burton P. Isaakidis |
| author_facet | F. Mangana L. D. Massaquoi R. Moudachirou R. Harrison T. Kaluangila G. Mucinya N. Ntabugi G. Van Cutsem R. Burton P. Isaakidis |
| author_sort | F. Mangana |
| collection | DOAJ |
| description | Abstract Background HIV continues to be the main determinant morbidity with high mortality rates in Sub-Saharan Africa, with a high number of patients being late presenters with advanced HIV. Clinical management of advanced HIV patients is thus complex and requires strict adherence to updated, empirical and simplified guidelines. The current study investigated the impact of the implementation of a new clinical guideline on the management of advanced HIV in Kinshasa, Democratic Republic of Congo (DRC). Methods A retrospective analysis of routine clinical data of advanced HIV patients was conducted for the periods; February 2016 to March 2017, before implementation of new guidelines, and November 2017 to July 2018, after the implementation of new guidelines. Eligible patients were patients with CD4 < 200 cell/μl and presenting with at least 1 of 4 opportunistic infections. Patient files were reviewed by a medical doctor and a committee of 3 other doctors for congruence. Statistical significance was set at 0.05%. Results Two hundred four and Two hundred thirty-one patients were eligible for inclusion before and after the implementation of new guidelines respectively. Sex and age distributions were similar for both periods, and median CD4 were 36 & 52 cell/μl, before and after the new guidelines implementation, respectively. 40.7% of patients had at least 1 missed/incorrect diagnosis before the new guidelines compared to 30% after new guidelines, p < 0.05. Clinical diagnosis for TB and toxoplasmosis were also much improved after the implementation of new guidelines. In addition, only 63% of patients had CD4 count test results before the new guidelines compared to 99% of patients after new guidelines. Death odds after the implementation of new guidelines were significantly lower than before new guidelines in a multivariate regression model that included patients CD4 count and 10 other covariates, p < 0.05. Conclusions Simplification and implementation of a new and improved HIV clinical guideline coupled with the installation of laboratory equipment and point of care tests potentially helped reduce incorrect diagnosis and improve clinical outcomes of patients with advanced HIV. Regulating authorities should consider developing simplified versions of guidelines followed by the provision of basic diagnostic equipment to health centers. |
| first_indexed | 2024-12-22T05:03:33Z |
| format | Article |
| id | doaj.art-b449f7089abf443b887d048b52e2b946 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-22T05:03:33Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-b449f7089abf443b887d048b52e2b9462022-12-21T18:38:11ZengBMCBMC Infectious Diseases1471-23342020-10-012011910.1186/s12879-020-05470-0Impact of the implementation of new guidelines on the management of patients with HIV infection at an advanced HIV clinic in Kinshasa, Democratic Republic of Congo (DRC)F. Mangana0L. D. Massaquoi1R. Moudachirou2R. Harrison3T. Kaluangila4G. Mucinya5N. Ntabugi6G. Van Cutsem7R. Burton8P. Isaakidis9Médecins Sans FrontièresMédecins Sans FrontièresMédecins Sans FrontièresMédecins Sans FrontièresMédecins Sans FrontièresMédecins Sans FrontièresMédecins Sans FrontièresSouthern Africa Medical Unit, Médecins Sans FrontièresSouthern Africa Medical Unit, Médecins Sans FrontièresSouthern Africa Medical Unit, Médecins Sans FrontièresAbstract Background HIV continues to be the main determinant morbidity with high mortality rates in Sub-Saharan Africa, with a high number of patients being late presenters with advanced HIV. Clinical management of advanced HIV patients is thus complex and requires strict adherence to updated, empirical and simplified guidelines. The current study investigated the impact of the implementation of a new clinical guideline on the management of advanced HIV in Kinshasa, Democratic Republic of Congo (DRC). Methods A retrospective analysis of routine clinical data of advanced HIV patients was conducted for the periods; February 2016 to March 2017, before implementation of new guidelines, and November 2017 to July 2018, after the implementation of new guidelines. Eligible patients were patients with CD4 < 200 cell/μl and presenting with at least 1 of 4 opportunistic infections. Patient files were reviewed by a medical doctor and a committee of 3 other doctors for congruence. Statistical significance was set at 0.05%. Results Two hundred four and Two hundred thirty-one patients were eligible for inclusion before and after the implementation of new guidelines respectively. Sex and age distributions were similar for both periods, and median CD4 were 36 & 52 cell/μl, before and after the new guidelines implementation, respectively. 40.7% of patients had at least 1 missed/incorrect diagnosis before the new guidelines compared to 30% after new guidelines, p < 0.05. Clinical diagnosis for TB and toxoplasmosis were also much improved after the implementation of new guidelines. In addition, only 63% of patients had CD4 count test results before the new guidelines compared to 99% of patients after new guidelines. Death odds after the implementation of new guidelines were significantly lower than before new guidelines in a multivariate regression model that included patients CD4 count and 10 other covariates, p < 0.05. Conclusions Simplification and implementation of a new and improved HIV clinical guideline coupled with the installation of laboratory equipment and point of care tests potentially helped reduce incorrect diagnosis and improve clinical outcomes of patients with advanced HIV. Regulating authorities should consider developing simplified versions of guidelines followed by the provision of basic diagnostic equipment to health centers.http://link.springer.com/article/10.1186/s12879-020-05470-0Advanced HIVHIV clinical guidelineHIV infectionHIV clinical managementSub-Saharan Africa |
| spellingShingle | F. Mangana L. D. Massaquoi R. Moudachirou R. Harrison T. Kaluangila G. Mucinya N. Ntabugi G. Van Cutsem R. Burton P. Isaakidis Impact of the implementation of new guidelines on the management of patients with HIV infection at an advanced HIV clinic in Kinshasa, Democratic Republic of Congo (DRC) BMC Infectious Diseases Advanced HIV HIV clinical guideline HIV infection HIV clinical management Sub-Saharan Africa |
| title | Impact of the implementation of new guidelines on the management of patients with HIV infection at an advanced HIV clinic in Kinshasa, Democratic Republic of Congo (DRC) |
| title_full | Impact of the implementation of new guidelines on the management of patients with HIV infection at an advanced HIV clinic in Kinshasa, Democratic Republic of Congo (DRC) |
| title_fullStr | Impact of the implementation of new guidelines on the management of patients with HIV infection at an advanced HIV clinic in Kinshasa, Democratic Republic of Congo (DRC) |
| title_full_unstemmed | Impact of the implementation of new guidelines on the management of patients with HIV infection at an advanced HIV clinic in Kinshasa, Democratic Republic of Congo (DRC) |
| title_short | Impact of the implementation of new guidelines on the management of patients with HIV infection at an advanced HIV clinic in Kinshasa, Democratic Republic of Congo (DRC) |
| title_sort | impact of the implementation of new guidelines on the management of patients with hiv infection at an advanced hiv clinic in kinshasa democratic republic of congo drc |
| topic | Advanced HIV HIV clinical guideline HIV infection HIV clinical management Sub-Saharan Africa |
| url | http://link.springer.com/article/10.1186/s12879-020-05470-0 |
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